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Scientists decipher mechanism of chemotherapy induced female infertility

Many chemotherapeutics act by damaging the DNA. Since cancer cells divide more often than most normal cells, they react more sensitive to DNA damaging agents.

17 Apr 2018

Targeting opioid receptor offers relief for chronic itching

A common side effect of opioids is intense itching -- a problem for some patients who need the drugs for pain relief and for others fighting addiction.

17 Apr 2018

FDA approves combination immunotherapy for treatment of kidney cancer

The standard of care for kidney cancer patients continues to improve. The U.S. Food and Drug Administration granted approval to the combination of two immunotherapy drugs, ipilimumab and nivolumab, for the treatment of metastatic kidney cancer.

17 Apr 2018

Scientists provide insight into how gene associated with autoimmunity contributes to disease

Researchers have provided new insight into how a gene associated with autoimmunity contributes to disease in humans.

17 Apr 2018

Study reports promising novel approach to treat therapy resistant pediatric brain tumors

Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children.

17 Apr 2018

Research reveals new mechanism by which HIV evades the immune system

Scientists have just discovered a new mechanism by which HIV evades the immune system, and which shows precisely how the virus avoids elimination. The new research shows that HIV targets and disables a pathway involving a number of biological molecules that are key in blocking viral activity and clearing infection.

17 Apr 2018

Mouse study shows how tungsten accumulates in the bones

New research shows how and where tungsten accumulates in bones of mice exposed to the element through drinking water. The findings, by a team of chemists and biologists at McGill University, could add to doubts over the once-universal assumption that tungsten poses little or no health risk to the general human population.

17 Apr 2018

Two immune checkpoint inhibitors efficiently block leukemia development in preclinical tests

Chronic lymphocytic leukemia is a hematological malignancy that originates in the blood-forming cells of the bone marrow and spreads to other organs through the bloodstream.

17 Apr 2018

Bacterial 'gene swapping' affects emergence and spread of infectious diseases

A new study by scientists at the University of Liverpool documents, for the first time, how the ability of bacteria to swap genetic material with each other can directly affect the emergence and spread of globally important infectious diseases.

17 Apr 2018

Study challenges use of whole-brain radiation for small-cell lung cancer patients with brain metastases

Lung cancer often metastasizes to the brain. Historically, brain metastases have been treated with whole-brain radiation therapy.

17 Apr 2018

Researchers discover potential hurdle for personalized medicine

A recent study has shown that loss of the Erk oncogene can stimulate tumorigenesis in cells where Ras has been eliminated. The findings may have important consequences for the development of personalized medicines that target Ras.

17 Apr 2018

Large ALS-causing protein aggregates protect rather than harm neurons

Scientists at the UNC School of Medicine have made a significant advance in the understanding of the complex and fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

17 Apr 2018

Researchers generate stable cartilage tissue from adult mesenchymal stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

16 Apr 2018

MD Anderson research provides insight into memory T cell development and disease relapse

Just like people, some T cells have excellent memories. These subtypes known as memory T cells may explain why some immunotherapies are more effective than others and potentially lead to researchers designing more effective studies using combination checkpoint blockade treatments, according to experts at The University of Texas MD Anderson Cancer Center.

16 Apr 2018

Research sheds light on links between brain growth and post-natal sensory experiences

New research by University of Toronto neuroscientists sheds light on links between early brain growth and sensations experienced by animals soon after birth.

16 Apr 2018

Engineered immune cells clear deadly pediatric brain tumor in mice

Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated.

16 Apr 2018

Anti-PD-1 treatment reduces tumor size and post-surgical relapse of lung cancer

A drug given to early stage lung cancer patients before they undergo surgery showed major tumor responses in the removed tumor and an increase in anti-tumor T-cells that remained after the tumor was removed, which resulted in fewer relapse cases in the patients.

16 Apr 2018

CNIO researchers determine structure of protein complex related to cell survival

A team from the Spanish National Cancer Research Centre has determined for the first time the high-resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cancer.

16 Apr 2018

New tool developed to protect women from HIV infection

Scientists at the University of Waterloo have developed a new tool to protect women from HIV infection.

16 Apr 2018

Finding ways to reverse obesity’s lingering, pro-cancer effects

Like exposure to too much sun and drinking alcohol, obesity is a risk factor for cancer. Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center are working to be a part of the solution -- they want to find ways to reverse obesity-linked biological changes in the body that are associated with cancer growth.

16 Apr 2018