DNA Methylation News and Research

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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.

Simple blood test found to accurately diagnose and classify brain tumors

A simple but highly sensitive blood test has been found to accurately diagnose and classify different types of brain tumors, resulting in more accurate diagnosis, less invasive methods and better treatment planning for patients, in the future.

22 Jun 2020

Young adults from disadvantaged neighborhoods show differences in the epigenome

The neighborhood a child grows up in may influence their health for years to come in previously invisible ways.

21 Jun 2020

Researchers analyze immune properties of ancient human DNA

Could remnants of DNA from a now-extinct human subspecies known as the Denisovans help boost the immune functions of modern humans?

16 Jun 2020

UIC Center for Alcohol Research in Epigenetics receives $8.2 million NIH grant

The University of Illinois at Chicago received $8.2 million from the National Institute on Alcohol Abuse and Alcoholism to continue the Center for Alcohol Research in Epigenetics and its research on how alcohol affects genes through epigenetics -- chemical changes to DNA, RNA or proteins that alter the expression of genes without directly modifying them.

4 Jun 2020

Base Genomics launches and raises $11 million USD to progress development of its TAPS technology

Epigenetics company Base Genomics has launched with a team of leading scientists and clinicians to set a new gold standard in DNA methylation detection.

4 Jun 2020

First detailed study of the epigenetic landscape of human tumor organoids

The researcher Manel Esteller performs the first massive epigenetic characterization in organoids or 3D cancer cultures and makes the data available to the research community to facilitate new findings on tumor development and progression.

15 May 2020

First detailed study of the epigenetic landscape of human tumor organoids

Frequently, promising cancer therapies fail when applied to patients in the real clinical setting. This occurs despite many of these new treatments demonstrating promising results at the preclinical stage in the lab.

13 May 2020

Study reveals the effect of ancestry on molecular makeup of cancer

Questions about the genealogical imprint of tumors have hovered over cancer research since the completion of the Human Genome Project in 2003.

11 May 2020

Breakthrough study could revolutionize cancer treatment

Scientists have used 3D models to break down the DNA behavior of cancer cells, in a breakthrough new study which could revolutionize treatment for the disease.

10 May 2020

New tool may offer a novel approach to prevent multiple chronic diseases

A study just released by Columbia University Mailman School of Public Health is reporting a blood-DNA-methylation measure that is sensitive to variation in the pace of biological aging among individuals born the same year.

6 May 2020

Researchers identify a new risk factor for multiple neurodegenerative diseases

Scientists at the HudsonAlpha Institute for Biotechnology, the University of California, San Francisco (UCSF), and the University of Alabama at Birmingham (UAB), have identified a new risk factor for multiple neurodegenerative diseases.

28 Apr 2020

Age-related DNA modifications linked with susceptibility to eye disease

National Eye Institute researchers profiling epigenomic changes in light-sensing mouse photoreceptors have a clearer picture of how age-related eye diseases may be linked to age-related changes in the regulation of gene expression.

21 Apr 2020

NEI researchers link age-related DNA modifications to susceptibility to eye disease

Researchers profiling epigenomic changes in mouse photoreceptors suggest that age-related eye diseases may be linked to gene expression.

21 Apr 2020

Women born by cesarean have greater risk of obesity and diabetes

A new study published in the open-access journal JAMA Network Open in April 2020 suggests that women born by way of a Cesarean section are at higher risk of developing obesity as well as type 2 diabetes mellitus in adult life.

13 Apr 2020

Researchers elucidate new mechanism for controlling DNA methylation in cells

Why normal cells turn into cancer cells One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation.

17 Mar 2020

Characterization of DNAm status of MMPs and TIMPs in atheromatous plaques

Oncotarget Volume 11, Issue 10 reported that the statistically associated Cp G sites were analyzed in blood samples from two separate atherothrombotic stroke cohorts, ischemic stroke-cohort 1: 37 atherothrombotic patients and 6 controls, ischemic stroke-cohort 2: 80 atherothrombotic patients and 184 controls.

13 Mar 2020

Length of pregnancy related to chemical DNA changes in newborns

Researchers from Karolinska Institutet in Sweden have together with an international team mapped the relationship between length of pregnancy and chemical DNA changes in more than 6,000 newborn babies.

2 Mar 2020

Potential genetic test for earlier Alzheimer's diagnosis

A new study published in the journal Epigenetics in February 2020 reports that changes in the methylation status of the Presenilin 1 (PSEN1) gene could help diagnose Alzheimer's disease (AD) earlier. This study shows for the first time that methylation of this gene is a common feature in AD.

1 Mar 2020

New way to chart human genome with CRISPR/nanopore sequencing technique

In search of new ways to sequence human genomes and read critical alterations in DNA, researchers at Johns Hopkins Medicine say they have successfully used the gene cutting tool CRISPR to make cuts in DNA around lengthy tumor genes, which can be used to collect sequence information.

24 Feb 2020

Biological age metric can provide new opportunities for preventative healthcare

People age in different ways. Biological age is a metric that scientists use to predict health risks, the relevance of which can be enhanced by combining different markers. Particularly important markers are frailty and the epigenetic clock, write researchers from Karolinska Institutet in a study published in eLife.

11 Feb 2020