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Transport of bacterial substrates through injectisome observed almost in real time

When attacking body cells, bacteria, such as salmonellae or Yersinia (plague pathogens), inject specific bacterial proteins through hollow, syringe-like structures - called injectisomes - into the host cells. These substances reprogram the cells and can thus overcome their defense. From then on, they can infiltrate the cells unhindered in large numbers, and trigger diseases such as typhus, plague, or cholera.

13 Dec 2013

Market research report on global and China insulin industry

As the third largest human health disease following neoplastic disease, cardiovascular and cerebrovascular diseases, the number of diabetic patients has continued growing from 246 million in 2007 to 382 million in 2013 at a compound annual growth rate of 7.6%.

12 Dec 2013

Antibody-toxin compound shows compelling antitumor activity in non-Hodgkin lymphomas patients

A toxin linked to a targeted monoclonal antibody has shown "compelling" antitumor activity in patients with non-Hodgkin lymphomas who were no longer responding to treatment, according to a report from Dana-Farber Cancer Institute.

11 Dec 2013

Viewpoints: Obamacare has resisted death throes before; website success stories from 3 governors; health law taking a toll on choice of doctors in Medicare Advantage

The first time Obamacare seemed finished, doomed, doornail-dead, the voters of Massachusetts played the would-be executioner. In January 2010, they sent a pickup-driving Republican to the Senate to fill Ted Kennedy's seat, apparently depriving the health care bill of its crucial 60th vote and sending Democrats scrambling for a Plan B. ... the deeper force at work, the reason that these near-death experiences keep happening, isn't a website or a broken presidential promise. It's a problem inherent to contemporary liberalism, which is that liberals' proudest achievement, the modern welfare state, tends to resist, corrupt and baffle their efforts at comprehensive reform (Ross Douthat, 11/16).

19 Nov 2013

MIT researchers design stealth drug delivery system to attack TNBC cells

Some of the most dangerous cancers are those that can outmaneuver the very drugs designed to defeat them, but researchers are now reporting a new Trojan-horse approach. In a preliminary study in the journal ACS Nano focusing on a type of breast cancer that is highly resistant to current therapies, they describe a way to sneak small particles into tumor cells, lower their defenses and attack them with drugs, potentially making the therapy much more effective.

25 Oct 2013

Researchers discover potential method to identify TBI using positron PET scans

Accurately diagnosing traumatic brain injuries (TBI) and concussions is difficult, as standard CT or MRI scans can't see most changes to the brain caused by these injuries.

24 Oct 2013

Scientist receives NIH New Innovator Award to design innovative approaches for cancer treatment

Derek Taylor, PhD, a member of the Case Western Reserve School of Medicine, has been awarded the prestigious New Innovator Award by the National Institutes of Health (NIH).

22 Oct 2013

Viewpoints: Obamacare's redistribution will 'wreck' U.S. work ethic; health law problems can't obscure pent up demand

A new wave of redistribution will arrive in America on Jan. 1, primarily thanks to the Affordable Care Act. The president's health-insurance plan forces those who hire, work and produce to pay full price for health care, while creating generous discounts for practically everyone else (Casey B. Mulligan, 10/2).

4 Oct 2013

Research provides answers to issues related to human pathogens in mushroom growth substrate

Strict requirements on the use of animal manures in fresh produce production imposed by the new federal food-safety law threatened to adversely impact the mushroom industry, which relies on horse and poultry manure for a specialized growth substrate.

23 Sep 2013

Researchers present research outcomes on food risk and benefit communication created by FoodRisC

Consumers in Europe are often overwhelmed with the vast amounts of food risk and benefit information presented to them, some of which can be perceived as conflicting or confusing.

13 Sep 2013

Using large doses of codeine may heighten sensitivity to pain

Using large and frequent doses of the pain-killer codeine may actually produce heightened sensitivity to pain, without the same level of relief offered by morphine, according to new research from the University of Adelaide.

13 Sep 2013

Strides therapeutic approach helps autistic children reach breakthroughs in communication

Luke, a 7-year-old autistic child had primarily only expressed requests to his parents (e.g., I want a drink), but this past year he was given a 1-pound iPad, introduced to a 1,000 pound horse and a special program called Strides©.

11 Sep 2013

Abraxane drug gets FDA approval for patients with advanced pancreatic cancer

The U.S. Food and Drug Administration today approved Abraxane for patients with advanced pancreatic cancer, following 7 years of rigorous clinical trials overseen by Scottsdale Healthcare and the Translational Genomics Research Institute.

7 Sep 2013

HIV-infected people who carry gene face greater risk of contracting cryptococcal disease

HIV-infected people who carry a gene for a specific protein face a 20-fold greater risk of contracting cryptococcal disease, according to a study published in mBio-, the online open-access journal of the American Society for Microbiology.

27 Aug 2013

Virtual 3-D heart model analyzes defibrillator placement in children born with heart defects

The small size and abnormal anatomy of children born with heart defects often force doctors to place lifesaving defibrillators entirely outside the heart, rather than partly inside — a less-than-ideal solution to dangerous heart rhythms that involves a degree of guesstimating and can compromise therapy.

22 Aug 2013

Research suggests gene therapy approach may be feasible option to treat Rett Syndrome

The concept behind gene therapy is simple: deliver a healthy gene to compensate for one that is mutated. New research published today in the Journal of Neuroscience suggests this approach may eventually be a feasible option to treat Rett Syndrome, the most disabling of the autism spectrum disorders.

21 Aug 2013

Researchers improve efficacy of RASV by modifying pathogen’s ability to survive in hostile environment

The bacterial pathogen Salmonella has a notorious capacity for infection. Last year alone, according to the Center for Disease Control, various species of Salmonella caused multistate disease outbreaks linked with contaminated peanut butter, mangoes, ground beef, cantaloupe, poultry, tuna fish, small turtles and dry dog food.

7 Aug 2013

H7 influenza may spillover repeatedly into humans, say scientists

The H7N9 avian flu strain that emerged in China earlier this year has subsided for now, but it would be a mistake to be reassured by this apparent lull in infections. The virus has several highly unusual traits that paint a disquieting picture of a pathogen that may yet lead to a pandemic, according to lead scientists from the National Institute of Allergy and Infectious Diseases.

10 Jul 2013

Viewpoints: Late hospital bills perplex consumers; Personal health data can 'revolutionize' care

Flavio de Pecol hit the trifecta after taking his daughter to the emergency room for a horse-riding injury: hours of waiting, a 16-mile ambulance ride to a different facility and bills for more than $40,000. At least, he thought, that was the end of it. But nearly two years (later), ... De Pecol, of Newport Beach, has received yet another bill, this time for $1,054.53. ... "How can I trust that this isn't a mistake when a hospital takes 21 months to bill me?" De Pecol asked. ... Good questions, and yet another example of the way consumers are at the mercy of the healthcare industry's opaque and byzantine billing practices (David Lazarus, 6/25).

28 Jun 2013

$Study provides insights into characteristics of sports-related facial fractures in young athletes$

Study provides insights into characteristics of sports-related facial fractures in young athletes

Facial fractures are relatively common, and potentially serious, sports-related injuries among children participating in a wide range of sports, according to a study in the June issue of Plastic and Reconstructive Surgery-, the official medical journal of the American Society of Plastic Surgeons.

30 May 2013