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Using PCR-based genotyping to detect SARS-CoV-2 delta-omicron coinfection

In a recently published ‘Letter to the Editor’ in the journal Microbiology Spectrum, scientists have described the procedure of polymerase chain reaction (PCR)-based genotyping in identifying delta-omicron coinfection in clinical samples.

9 May 2022

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Researchers utilized a CRISPR/Cas9 system to evaluate the usage of tRNA by deleting two tRNA genes from the genomes of hyper hepatocellular carcinoma and human near-haploid chronic myeloid leukemia cells.

27 Apr 2022

Role of complement factor H-related protein 5 in venous thromboembolism and COVID-19

A new study discussed the role of complement factor H-related protein 5 (CFHR5) in venous thromboembolism (VTE) patients and hospitalized COVID-19 patients.

25 Apr 2022

Persistent loss of smell after COVID-19 associated with altered olfactory epithelial gene expression

Researchers performed histology of the olfactory epithelium for smell loss measurements in patients with post-acute sequelae of SARS-CoV-2 infection.

20 Apr 2022

Treg cell Notch receptors drive SARS-CoV-2-induced MIS-C

In a recent study under consideration at Nature Portfolio Journal and posted to the Research Square* preprint server, researchers demonstrated the evolution of multi-system inflammatory syndrome in children (MIS-C) following acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

12 Apr 2022

Researchers discover over 40 new genetic markers for Alzheimer’s disease

A new Nature Genetics study describes over 70 gene markers that appear to be significantly associated with AD risk using translational genomics.

6 Apr 2022

Improving our understanding of a severe pregnancy sickness (Hyperemesis Gravidarum)

News-Medical talks to Dr. Marlena Fejzo about a breakthrough in the understanding of hyperemesis gravidarum, and how it could improve maternal health around the world.

5 Apr 2022

Study suggests severe neuroinvasion by SARS-CoV-2 in individuals with alcohol use disorder

Researchers investigated the effect of repeated alcohol exposure and withdrawal on angiotensin-converting enzyme 2 and transmembrane serine protease 2 expression, putative regulators of SARS-CoV-2 entry, in discrete brain regions.

4 Apr 2022

The effects of SARS-CoV-2 infection in different ancestry origins from the same region

Researchers examined whether varied allelic frequencies of the HLA gene in people of different ancestral origins were associated with increased susceptibility to SARS-CoV-2 infection and disease severity.

4 Apr 2022

Study investigates whether coinfection with multiple SARS-CoV-2 variants exists in COVID-19 patients

A new study shows that multiple variants of this virus may coinfect the same patient, using both genomic sequencing data and computational models.

30 Mar 2022

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

Researchers evaluate antiviral effects of CD63 tetraspanin extracellular vesicles against SARS-CoV-2 and HIV-1.

22 Mar 2022

Covalent protein nanobodies for neutralizing SARS-CoV-2 and its variants

Researchers developed covalent nanobodies to neutralize severe acute respiratory syndrome coronavirus-2 and its variants.

18 Mar 2022

Whole-genome sequencing for determination of factors associated with critical COVID-19

In a recent study published in the journal Nature as an early release unedited manuscript, researchers conducted whole genomic sequencing (WGS) to ascertain factors contributing to critical coronavirus disease 2019 (COVID-19).

8 Mar 2022

Recurrent mutations across the SARS-CoV-2 genome associated with long-term infections in immunodeficient patients

Researchers identified recurrent mutations in SARS-CoV-2.

8 Mar 2022

SARS-CoV-2 variant identification by RT-qPCR assays targeting mutations

In a recent study posted to the medRxiv* preprint server, researchers investigated the efficacy of diagnostic tests for identifying severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants of concern (VOCs).

8 Mar 2022

Study does not find association between hematological parameters and COVID-19-related hospitalization

Researchers examine the genetic factors influencing hematological parameters in SARS-CoV-2 infection.

4 Mar 2022

Genetically informed brain atlases help identify hundreds of genomic loci

An international team of scientists has used atlases of the human brain informed by genetics to identify hundreds of genomic loci. Loci is plural for locus, and in genetics indicates the physical location of a gene or variant on a chromosome.

7 Feb 2022

Study investigates if prior SARS-CoV-2 infection increases sensitivity to toxin that induces parkinsonism

A recent study explored whether individuals who have recovered from mild to moderate or severe COVID-19 may have an increased risk for developing Parkinson’s disease in the future.

7 Feb 2022

Genetic marker linked to higher risk of death in COVID-19 patients

A new study discusses the importance of single nucleotide polymorphisms in the Rab46 gene as a marker of adverse outcomes in high-risk COVID-19 patients.

23 Jan 2022

New pathways responsible for hepatocellular carcinoma identified

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. It is one of leading causes of cancer-related deaths globally, with more than 700,000 new cases and 600,000 estimated HCC deaths each year.

18 Jan 2022

Locus News and Research

Using PCR-based genotyping to detect SARS-CoV-2 delta-omicron coinfection

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Role of complement factor H-related protein 5 in venous thromboembolism and COVID-19

Persistent loss of smell after COVID-19 associated with altered olfactory epithelial gene expression

Treg cell Notch receptors drive SARS-CoV-2-induced MIS-C

Researchers discover over 40 new genetic markers for Alzheimer’s disease

Improving our understanding of a severe pregnancy sickness (Hyperemesis Gravidarum)

Study suggests severe neuroinvasion by SARS-CoV-2 in individuals with alcohol use disorder

The effects of SARS-CoV-2 infection in different ancestry origins from the same region

Study investigates whether coinfection with multiple SARS-CoV-2 variants exists in COVID-19 patients

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

Covalent protein nanobodies for neutralizing SARS-CoV-2 and its variants

Whole-genome sequencing for determination of factors associated with critical COVID-19

Recurrent mutations across the SARS-CoV-2 genome associated with long-term infections in immunodeficient patients

SARS-CoV-2 variant identification by RT-qPCR assays targeting mutations

Study does not find association between hematological parameters and COVID-19-related hospitalization

Genetically informed brain atlases help identify hundreds of genomic loci

Study investigates if prior SARS-CoV-2 infection increases sensitivity to toxin that induces parkinsonism

Genetic marker linked to higher risk of death in COVID-19 patients

New pathways responsible for hepatocellular carcinoma identified

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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