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EPFL researchers achieve near-perfect control of individual molecules for improving sensing precision

Aleksandra Radenovic, head of the Laboratory of Nanoscale Biology in the School of Engineering, has worked for years to improve nanopore technology, which involves passing a molecule like DNA through a tiny pore in a membrane to measure an ionic current.

19 Jun 2023

New method offers insights into mechanisms of staphylococcal pathogenesis

Nearly one in three people globally unknowingly carries Golden staph, or Staphylococcus aureus, in their nose or on their skin. While the bacterium is harmless to most, it can lead to serious infection and even death if it enters the bloodstream through a cut, surgical wound or catheter.

16 Jun 2023

Insilico announces new multimodal transformer-based aging clock for processing diverse data sets

Clinical stage generative artificial intelligence (AI)-driven drug discovery company Insilico Medicine ("Insilico") has announced a new multimodal transformer-based aging clock that is capable of processing diverse data sets and providing insights into biomarkers for aging, mapping them to genes relevant to both aging and disease, and discovering new therapeutic targets designed to slow or reverse both aging and aging-related diseases.

15 Jun 2023

Detailed 3D images of the synapse offer precise geometry of interactions between individual cells

Scientists have created one of the most detailed 3D images of the synapse, the important juncture where neurons communicate with each other through an exchange of chemical signals. These nanometer scale models will help scientists better understand and study neurodegenerative diseases such as Huntington's disease and schizophrenia.

15 Jun 2023

Tiny device 'sees' and creates memories in a similar way to humans

Researchers have created a small device that 'sees' and creates memories in a similar way to humans, in a promising step towards one day having applications that can make rapid, complex decisions such as in self-driving cars.

14 Jun 2023

Researchers create a diagnostic test to identify functional sperm in infertile men

In a recent study, researchers created a diagnostic test to identify functional sperm in infertile men that could change the treatment of male infertility and assisted reproductive technology.

14 Jun 2023

Algorithm from a video game provides insights into the behavior of molecules within live brain cells

University of Queensland researchers have used an algorithm from a video game to gain insights into the behavior of molecules within live brain cells.

14 Jun 2023

An analysis of the differential effect and the impact of SARS-CoV-2 infection on semen quality

Study analyzed the impact of SARS-CoV-2 infection on semen quality.

14 Jun 2023

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals -; from fuels to fabrics and drugs -; beyond the normal repertoire of microbes.

13 Jun 2023

UCL researchers produce first image of the structures that power human cilia

The first image of the structures that power human cilia – the tiny, hairlike projections that line our airways – has been produced by a team involving UCL researchers and could lead to much-needed treatments for people with rare cilial diseases.

13 Jun 2023

Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

Researchers evaluated the therapeutic efficacy of Navoximod.

13 Jun 2023

New cell culture model generates the alveolar macrophage in the lab

Researchers at Texas Biomedical Research Institute have succeeded in generating the lung's most important immune cell, the alveolar macrophage, in the lab.

12 Jun 2023

Study reveals how p62 bodies control redox-independent stress response

Cellular stress, or oxidative stress, occurs when there is a buildup of reactive oxygen species (ROS), which interferes with cellular mechanisms and can even cause damage to proteins, lipids, and DNA.

12 Jun 2023

Scientists determine the atomic-level structure of a zinc-transporter protein

Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory have determined the atomic-level structure of a zinc-transporter protein, a molecular machine that regulates levels of this crucial trace metal micronutrient inside cells.

9 Jun 2023

Mechanistic insights into how the SARS-CoV-2 virus affects the nervous system, alters its function, and causes neuropathology

Study demonstrates that SARS-CoV-2 infection and viral fusogens cause glial and neuronal fusion.

9 Jun 2023

Cryo-EM reveals key atomic structures of the ends of actin filament

Actin filaments -; protein structures critical to living movement from single cells to animals -; have long been known to have polarity associated with their physical characteristics, with growing "barbed" and shrinking "pointed" ends.

8 Jun 2023

Teaming up with the patient’s immune system to combat cancer

The fact that our immune systems capture and destroy nanoparticles and the drugs they carry has been a problem in the field of nanomedicine for some time. But, in the fight against cancer, researchers are now attempting to exploit this problem to their advantage.

8 Jun 2023

Single virus binds to a single receptor, study reveals

In Europe, the pandemic triggered in 2020 by the SARS-CoV-2 coronavirus is now largely under control. But why this virus is able to spread so efficiently remains unclear. A team of researchers led by Dr. Simone Backes, Dr. Gerti Beliu and Prof. Dr. Markus Sauer of the Julius Maximilians University of Würzburg (JMU) has now shown in a publication in "Angewandte Chemie" that some previous assumptions need to be reconsidered.

8 Jun 2023

New process can help to design drugs with fewer or no side effects

Have you ever wondered how drugs reach their targets and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane.

7 Jun 2023

Scientists uncover key molecular culprit in ALS: PEG10 gene implicated in pathogenesis

UBQLN2 dysfunction in ALS leads to elevated PEG10 levels, suggesting a role for retrotransposon activity in the disease. PEG10's nuclear localization alters gene expression involved in axon remodeling, implicating it as a contributing mechanism in ALS.

7 Jun 2023

Microscopy News and Research

EPFL researchers achieve near-perfect control of individual molecules for improving sensing precision

New method offers insights into mechanisms of staphylococcal pathogenesis

Insilico announces new multimodal transformer-based aging clock for processing diverse data sets

Detailed 3D images of the synapse offer precise geometry of interactions between individual cells

Tiny device 'sees' and creates memories in a similar way to humans

Researchers create a diagnostic test to identify functional sperm in infertile men

Algorithm from a video game provides insights into the behavior of molecules within live brain cells

An analysis of the differential effect and the impact of SARS-CoV-2 infection on semen quality

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

UCL researchers produce first image of the structures that power human cilia

Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

New cell culture model generates the alveolar macrophage in the lab

Study reveals how p62 bodies control redox-independent stress response

Scientists determine the atomic-level structure of a zinc-transporter protein

Mechanistic insights into how the SARS-CoV-2 virus affects the nervous system, alters its function, and causes neuropathology

Cryo-EM reveals key atomic structures of the ends of actin filament

Teaming up with the patient’s immune system to combat cancer

Single virus binds to a single receptor, study reveals

New process can help to design drugs with fewer or no side effects

Scientists uncover key molecular culprit in ALS: PEG10 gene implicated in pathogenesis

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Why use light scattering to analyze proteins and viral vectors?

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