Peripheral Artery Disease News and Research

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Peripheral arterial disease (PAD) occurs when leg arteries become narrowed or blocked by plaque. These blockages can result in severe pain for patients, limited physical mobility, and life-threatening non-healing leg ulcers. According to the American Heart Association, this condition affects approximately 8 to 12 million Americans. With only about 25 percent of PAD patients undergoing treatment, it is a disease that is largely under-diagnosed and under-treated. If left untreated, PAD can lead to critical leg ischemia, a condition where not enough blood is being delivered to the leg to keep the tissue alive. Total loss of circulation to the legs and feet can cause gangrene and lead to amputation.

Auckland physician performs first patient implant of Boston Scientific Innova DES System

Launching a key clinical trial expected to serve as the foundation for global regulatory approvals, a physician in Auckland, New Zealand has performed the first patient implant of the Boston Scientific Corporation Innova Drug-Eluting Stent System.

10 Oct 2013

AtheroMed completes patient enrollment in EASE clinical study for treating PAD

AtheroMed, a developer of innovative technologies for treating peripheral artery disease, announced that it has completed patient enrollment in the EASE clinical study. The EASE study results will be presented by Dr. Stephen Williams, Director, Vascular Medicine Center at Johns Hopkins University, during a Late Breaking Clinical Trials Session on Wednesday, October 9th, at the Vascular Interventional Advances conference in Las Vegas.

2 Oct 2013

Research shows commonly prescribed statin medicines can adversely affect cognitive function

New research that looked at whether two commonly prescribed statin medicines, used to lower low-density lipoprotein (LDL) or 'bad cholesterol' levels in the blood, can adversely affect cognitive function has found that one of the drugs tested caused memory impairment in rats.

26 Sep 2013

Multiple risk factors eliminate impact of AF on stroke risk, but more research is needed

Dr Benn Christiansen said: "We know that atrial fibrillation increases the risk of ischemic stroke. And in patients with atrial fibrillation or previous ischemic stroke, the risk of stroke increases with the number of risk factors.

5 Sep 2013

Rigel plans to focus on completing three clinical programs for ITP, DLE and dry eye disease

Rigel Pharmaceuticals, Inc. today announced its plans to focus the Company's resources on the completion of three lead clinical programs. These efforts include commencing a Phase 3 clinical study of fostamatinib, an oral SYK inhibitor, in Immune Thrombocytopenic Purpura pending discussions with regulatory agencies.

5 Sep 2013

Facebook groups are effective tool for increasing HIV testing among at-risk populations

Peer-led Facebook groups are an acceptable and effective tool for increasing home-based HIV testing among at-risk populations. HIV infection is a major health concern for men who have sex with men (MSM), especially among African Americans and Latinos who have high rates of incident cases and new diagnoses.

3 Sep 2013

Study: Compared to open bypass, stenting keeps circulation flowing longer in some patients

New Johns Hopkins research suggests that people who undergo minimally invasive placement of stents to open clogged leg arteries are significantly less likely than those who have conventional bypass surgery to need a second treatment for the condition within two years.

8 Aug 2013

Soaring rates of peripheral artery disease call for global attention

The number of people with peripheral artery disease worldwide has risen dramatically (by 23.5%) in just 10 years, from about 164 million in 2000 to 202 million in 2010, according to the first robust global estimates, published in The Lancet.

1 Aug 2013

Home-based exercise intervention improves walking performance, physical activity in PAD patients

In a trial that included nearly 200 participants with peripheral artery disease, a home-based exercise intervention with a group-mediated cognitive behavioral intervention component improved walking performance and physical activity in patients with PAD, according to a study in the July 3 issue of JAMA.

3 Jul 2013

AtheroNova starts AHRO-001 Phase 1 clinical trial for treatment of atherosclerosis

AtheroNova Inc., a biotech company focused on the research and development of compounds to safely regress atherosclerotic plaque and improve lipid profiles in humans, today announces achievement of a major milestone with the initiation of a Phase 1 clinical trial with its lead compound, AHRO-001. The Phase 1 study will evaluate the safety, tolerability and pharmacokinetics of AHRO-001 in healthy volunteers.

25 Jun 2013

NIH awards $12.7M to research groups to explore new treatments for patients in eight disease areas

The National Institutes of Health has awarded $12.7 million to match nine academic research groups with a selection of pharmaceutical industry compounds to explore new treatments for patients in eight disease areas, including Alzheimer's disease, Duchenne muscular dystrophy and schizophrenia.

19 Jun 2013

Report shows low baseline DBP associated with brain atrophy in patients with arterial disease

Low baseline diastolic blood pressure appears to be associated with brain atrophy in patients with arterial disease, whenever declining levels of blood pressure over time among patients who had a higher baseline BP were associated with less progression of atrophy, according to a report published Online First by JAMA Neurology, a JAMA Network publication.

11 Jun 2013

Avinger and PDL BioPharma close structured financing and royalty transaction

Avinger, Inc. and PDL BioPharma, Inc. (PDL) (NASDAQ: PDLI) announced today the closing of a structured financing and royalty transaction on April 18, 2013, in which PDL will provide Avinger with up to $40 million of mezzanine financing.

22 Apr 2013

Chelation therapy with drug disodium EDTA reduces risk of heart attack

Although chelation therapy with the drug disodium EDTA has been used for many years with limited evidence of efficacy for the treatment of coronary disease, a randomized trial that included patients with a prior heart attack found that use of a chelation regimen modestly reduced the risk of a composite of adverse cardiovascular outcomes.

27 Mar 2013

Quitting smoking linked with lower risk of cardiovascular disease among adults without diabetes

Among adults without diabetes, quitting smoking, compared with continuing smoking, was associated with a lower risk of cardiovascular disease despite subsequent weight gain, according to a study appearing in the March 13 issue of JAMA.

13 Mar 2013

Higher arm reading ‘overestimates true BP’

Using the higher of left and right arm single blood pressure readings taken sequentially leads to an overestimation of patients’ “true” level as determined by ambulatory monitoring, UK researchers warn.

11 Feb 2013

Higher arm reading ‘overestimates true BP’

8 Feb 2013

Ramipril puts spring in step of patients with intermittent claudication

Six months of treatment with the angiotensin-converting enzyme inhibitor ramipril produces notable improvements in the walking ability of patients with peripheral artery disease and intermittent claudication, shows a large randomized trial.

6 Feb 2013

Ramipril may improve pain-free walking among patients with PAD and intermittent claudication

Among patients with peripheral artery disease and intermittent claudication (pain in the calf that comes and goes, typically felt while walking), 24 weeks of treatment with the angiotensin-converting enzyme (ACE) inhibitor ramipril was associated with improvement in pain-free and maximum walking times and the physical health aspect of quality of life, according to a study appearing in the February 6 issue of JAMA.

6 Feb 2013

New AngioSculpt catheters from AngioScore can treat peripheral artery disease below the knee

AngioScore, Inc., a developer of novel angioplasty catheters for use in the treatment of cardiovascular disease, today announced the launch of its new 100 mm length AngioSculpt PTA Scoring Balloon Catheters for the treatment of peripheral artery disease (PAD) below the knee (BTK).

28 Jan 2013

Peripheral Artery Disease News and Research

Auckland physician performs first patient implant of Boston Scientific Innova DES System

AtheroMed completes patient enrollment in EASE clinical study for treating PAD

Research shows commonly prescribed statin medicines can adversely affect cognitive function

Multiple risk factors eliminate impact of AF on stroke risk, but more research is needed

Rigel plans to focus on completing three clinical programs for ITP, DLE and dry eye disease

Facebook groups are effective tool for increasing HIV testing among at-risk populations

Study: Compared to open bypass, stenting keeps circulation flowing longer in some patients

Soaring rates of peripheral artery disease call for global attention

Home-based exercise intervention improves walking performance, physical activity in PAD patients

AtheroNova starts AHRO-001 Phase 1 clinical trial for treatment of atherosclerosis

NIH awards $12.7M to research groups to explore new treatments for patients in eight disease areas

Report shows low baseline DBP associated with brain atrophy in patients with arterial disease

Avinger and PDL BioPharma close structured financing and royalty transaction

Chelation therapy with drug disodium EDTA reduces risk of heart attack

Quitting smoking linked with lower risk of cardiovascular disease among adults without diabetes

Higher arm reading ‘overestimates true BP’

Higher arm reading ‘overestimates true BP’

Ramipril puts spring in step of patients with intermittent claudication

Ramipril may improve pain-free walking among patients with PAD and intermittent claudication

New AngioSculpt catheters from AngioScore can treat peripheral artery disease below the knee

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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