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Study describes novel screening system that has potential to uncover effective ovarian cancer drugs

University of Chicago Medicine researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis. Their three-dimensional cell-culture system, adapted for high-throughput screening, has enabled them to identify small molecules that can inhibit adhesion and invasion, preventing ovarian cancers from spreading to nearby tissues.

10 Feb 2015

Dr. Hans Clevers receives ISSCR's McEwen Award for Innovation

The International Society for Stem Cell Research has awarded Dr. Hans Clevers, senior author on two important papers published recently in the scientific journal Cell, the society's McEwen Award for Innovation.

23 Jan 2015

Porvair Sciences releases 2015 catalogue of tissue culture plastics and epigenetic consumables

Porvair Sciences has released a new 2015 catalogue that describes its popular range of high quality tissue culture treated plastics and consumable products for Epigenetics.

From Chromatrap® - Porvair Sciences Ltd 22 Dec 2014

Canopus BioPharma study confirms efficacy of CB008 drug for Ebola Virus inhibition

Canopus BioPharma Inc. today announces that it has completed crucial research in confirming efficacy of a prescription drug: CB008 for Ebola Virus inhibition.

19 Dec 2014

Plymouth University receives £1.2M in funding to support capital investment for teaching facilities

Plymouth University has received funding in excess of £1.2M from the Higher Education Funding Council for England to support capital investment for teaching facilities in existing and proposed laboratories, at the headquarters of Plymouth University Peninsula Schools of Medicine and Dentistry (PUPSMD), Plymouth Science Park.

10 Dec 2014

Study suggests Golgi as potential drug target for Alzheimer's treatment

Alzheimer's disease (AD) progresses inside the brain in a rising storm of cellular chaos as deposits of the toxic protein, amyloid-beta (Aβ), overwhelm neurons. An apparent side effect of accumulating Aβ in neurons is the fragmentation of the Golgi apparatus, the part of the cell involved in packaging and sorting protein cargo including the precursor of Aβ. But is the destruction the Golgi a kind of collateral damage from the Aβ storm or is the loss of Golgi function itself part of the driving force behind Alzheimer's? This was the question for Yanzhuang Wang, Gunjan Joshi, and colleagues at the University of Michigan, Ann Arbor, as they set out to uncover the mechanism damaging the Golgi, using a transgenic mouse and tissue culture models of AD to look at what was going on.

6 Dec 2014

UNC researchers develop new approach to block KRAS oncogene

Researchers from the UNC School of Medicine and colleagues at The University of Texas MD Anderson Cancer Center have developed a new approach to block the KRAS oncogene, one of the most frequently mutated genes in human cancer.

14 Nov 2014

New multi-specimen perfusion bioreactor for reliable tissue growth introduced by Bose

Bose Corporation has introduced the 3DCulturePro™ system, a new multi-specimen perfusion bioreactor designed for biologists, biomedical researchers and scientists who require reproducible and reliable tissue growth. The 3DCulturePro system supports cell growth and 3D tissue culture in an easy-to-use, scalable configuration.

From TA Instruments 12 Nov 2014

Research opens door to potential new treatments for peripheral artery disease

Researchers have developed a technique to jump-start the body's systems for creating blood vessels, opening the door for potential new treatments for diseases whose impacts include amputation and blindness.

14 Oct 2014

Vitro toxicity testing an alternative to predict adverse health effects of drugs

In vitro toxicity testing is rapidly being adopted in the pharmaceutical, chemical, and cosmetics industries, for example, as an alternative to animal studies to predict adverse health effects of drugs and personal care products and the health consequences of environmental exposures.

8 Aug 2014

Viruses designed to kill cancer cells could boost effectiveness of chemotherapy to arms, legs

Viruses designed to target and kill cancer cells could boost the effectiveness of chemotherapy to the arms and legs and help avoid amputation, a new study reports.

22 Jul 2014

New approach for developing personalized gene therapies to treat retinitis pigmentosa

Columbia University Medical Center researchers have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss.

11 Jul 2014

New 5-layer flask enhances cell culture production

Porvair Sciences has announced a new 5-layer cell culture flask developed to fulfil the need of the growing number of applications that require large numbers of cells.

From Chromatrap® - Porvair Sciences Ltd 22 May 2014

Scientists discover novel protein fragments that may protect against Alzheimer's disease

The devastating loss of memory and consciousness in Alzheimer's disease is caused by plaque accumulations and tangles in neurons, which kill brain cells.

14 May 2014

Researchers explain how synapses remain stable for a long time

Synapses are the points of contact at which information is transmitted between neurons. Without them, we would not be able to form thoughts or remember things.

22 Apr 2014

Knopp and NIAID collaborate to investigate eosinophil-lowering effects of dexpramipexole

Knopp Biosciences LLC today announced a second collaboration with the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), to investigate the eosinophil-lowering effects of the investigational drug dexpramipexole.

13 Mar 2014

Research shows depletion of cholesteryl ester impairs prostate cancer aggressiveness

Researchers have discovered a link between prostate cancer aggressiveness and the accumulation of a compound produced when cholesterol is metabolized in cells, findings that could bring new diagnostic and treatment methods.

5 Mar 2014

Bruker opens new preclinical imaging center of excellence for the Americas

Bruker (NASDAQ: BRKR) today announced the official opening of a new Preclinical Imaging Center of Excellence for the Americas in Billerica, Massachusetts. The facility offers advanced development, demonstration and support facilities for Bruker’s industry-leading portfolio of preclinical imaging instrumentation and multimodal platforms.

4 Mar 2014

Plymouth University doctor wins national award for animal testing alternative

Dr. Gyorgy Fejer from Plymouth University School of Biomedical and Healthcare Sciences has received a national award for his work developing the lab-based creation of a type of mouse cell line which could be used in place of live animals for research related to infectious diseases.