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New understanding of biological effects of alcohol on genes within cells

Alcohol triggers the activation of a variety of genes that can influence the health and activity of brain cells, and new research from Weill Cornell Medical College in New York City sheds light on how that process occurs.

10 Dec 2007

Can fruit flies help treat stroke and transplant patients?

Reperfusion injury takes place when an animal or an organ is starved of oxygen, then exposed to oxygen again.

5 Dec 2007

Study of the post-transplant effects of alcohol use among lung donors

A recent study using an animal model of lung transplants shows that chronic alcohol consumption by the donor promotes scarring and airway injury after transplantation.

2 Dec 2007

Research suggests new direction for ALS treatment

A research team from Wake Forest University School of Medicine is the first to show that injections of a protein normally found in human cells can increase lifespan and delay the onset of symptoms in mice with ALS (amyotrophic lateral sclerosis), or Lou Gehrig's disease.

27 Nov 2007

RNA polymerase III mutation disrupts organ growth

The cellular mechanism that turns DNA into all of the thousands of proteins that make up a human body is itself both intricate and interesting.

27 Nov 2007

Study looks at progesterone for Alzheimer's

The first study on progesterone and Alzheimer's disease has found no clear preventive benefit for the widely prescribed hormone in an animal model.

27 Nov 2007

Alcohol may promote scarring and airway injury after transplantation

A recent study using an animal model of lung transplants shows that chronic alcohol consumption by the donor promotes scarring and airway injury after transplantation.

27 Nov 2007

New discoveries about nitric oxide can provide drugs for schizophrenia

Problems with memory and social function in patients with schizophrenia may result from an imbalance in the brain’s nitric oxide system.

21 Nov 2007

The immune system can stop the growth of a cancerous tumor without actually killing it

A multinational team of researchers has shown for the first time that the immune system can stop the growth of a cancerous tumor without actually killing it.

19 Nov 2007

Pre-malignant mammary lesions in dogs and humans display many of the same characteristics

...a discovery that could lead to better understanding of breast cancer progression and prevention for people and pets, said a Purdue University scientist from the School of Veterinary Medicine.

16 Nov 2007

Lonesome people may have lower levels of specific brain hormone

The anxiety and aggression that result from social isolation have been traced to altered levels of an enzyme that controls production of a brain hormone.

15 Nov 2007

Low doses of arsenic disrupt activity of development hormone

A team of Dartmouth Medical School (DMS) researchers has determined that low doses of arsenic disrupt the activity of a hormone critical in development. The finding is further evidence that arsenic at low doses (at levels found in U.S. drinking water in some areas) can be harmful.

15 Nov 2007

New drug may restore memory with Alzheimer's disease

A 2006 study by MetLife found that adults over age 55 fear Alzheimer's disease more than cancer, and with good reason. Alzheimer's creeps up on patients and their families, robbing more than half of all Americans over age 85 of their memory and ability to care for themselves.

14 Nov 2007

Anti-inflammation molecule helps fight MS-like disease

An immune system messenger molecule that normally helps quiet inflammation could be an effective tool against multiple sclerosis (MS). Neurology researchers led by Abdolmohamad Rostami, M.D., Ph.D., professor and chair of the Department of Neurology at Jefferson Medical College of Thomas Jefferson University and the Jefferson Hospital for Neuroscience in Philadelphia, have found that the protein interkeukin-27 (IL-27) helped block the onset or reverse symptoms in animals with an MS-like disease.

13 Nov 2007

Interaction between nicotine and alcohol impacts learning

The interaction between nicotine and alcohol, two of the most abused and co-abused drugs, can impact a person's ability to learn and could have implications for treating addiction, according to researchers at Temple University.

6 Nov 2007

First systemic therapy for fatal childhood disease - recessive dystrophic epidermolysis bullosa

University of Minnesota Children's Hospital, Fairview physicians have performed the first bone marrow and cord blood transplant to treat recessive dystrophic epidermolysis bullosa (RDEB).

5 Nov 2007

Immune cell age plays role in retinal damage in age-related macular degeneration

Studying a mouse model of age-related macular degeneration, the leading cause of blindness in older Americans, scientists at Washington University School of Medicine in St. Louis have found age is key in determining whether damaging blood vessels will form beneath the retina and contribute to vision loss.

2 Nov 2007

Preventing Morphine tolerance

Tolerance to the pain-relieving effects of morphine - which builds rapidly with prolonged use - can be prevented by blocking a key substance that's formed when the drug is taken, researchers at the Saint Louis University School of Medicine have discovered.

2 Nov 2007

Aggregation propensity, amyloid peptide toxicity and Alzheimer disease

Cells have evolved multiple mechanisms to ensure proper folding, but a number of molecular and biophysical events - such as changes in pH or temperature, mutations, and oxidation - can disrupt a protein's native shape.

31 Oct 2007

Therapeutic gene expression can be sustainable for 1 year

Researchers at the Board of Governors Gene Therapeutics Research Institute at Cedars-Sinai Medical Center have shown for the first time that it is possible to sustain therapeutic gene expression in the central nervous system for up to a year, even in the presence of an anti-viral immune response mechanism that is normally present in humans.

28 Oct 2007