Malignant News and Research

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FDA approves NDA filing for ibrutinib inhibitor in two B-cell malignancies

Pharmacyclics, Inc. (Nasdaq: PCYC) today announced that the U.S. Food and Drug Administration (FDA) has accepted for filing its New Drug Application (NDA) for the investigational oral Bruton's tyrosine kinase (BTK) inhibitor ibrutinib, for two B-cell malignancy indications: previously treated mantle cell lymphoma (MCL) and previously treated chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).

29 Aug 2013

Study shows genetic test to classify gastric cancers and match them to therapies offer best outcomes

Stomach cancer, one of the leading causes of cancer death worldwide, actually falls into three broad subtypes that respond differently to currently available therapies, according to researchers at Duke-NUS Graduate Medical School Singapore.

28 Aug 2013

Report shows women affected by DCIS prefer nonsurgical treatments

When ductal carcinoma in situ (DCIS, a preinvasive malignancy of the breast) is described as a high-risk condition rather than cancer, more women report that they would opt for nonsurgical treatments, according to a research letter by Zehra B. Omer, B.A., of Massachusetts General Hospital—Institute for Technology Assessment, Boston, and colleagues.

28 Aug 2013

Virttu Biologics treats first cohort of patients in SEPREHVIR Phase I/IIa study

Virttu Biologics Limited, a UK biotechnology company with expertise in the field of oncolytic viruses, has announced that it has treated the first cohort of patients in its Phase I/IIa clinical study of its oncolytic virus, SEPREHVIR (HSV1716) for the treatment of malignant pleural mesothelioma.

27 Aug 2013

Northwestern surgical oncologists use minimally invasive procedure to remove malignant melanoma

That's when she received the results from her dermatologist, who removed a part of the blister and had it tested. It turns out that little red bump was malignant melanoma, the leading cause of skin cancer death in the United States. It's a cancer that kills one person every hour, which translates to more than 8,700 Americans each year.

27 Aug 2013

Microscopic material in cells offers robust treatment for stroke

In the latest in a series of experiments testing the use of stem cells to treat neurological disease, researchers at Henry Ford Hospital have shown for the first time that microscopic material in the cells offers a "robust" treatment for crippling stroke.

27 Aug 2013

Screening strategy for ovarian cancer appears to be highly specific for detecting disease at early stages

A new screening strategy for ovarian cancer appears to be highly specific for detecting the disease before it becomes lethal. The strategy is described in a study published early online in Cancer, a peer-reviewed journal of the American Cancer Society. If verified in an ongoing clinical trial, it could potentially help save the lives of thousands of women each year in the United States alone.

26 Aug 2013

Study reports racial, ethnic differences in incidence of soft tissue sarcomas in young adults, adolescents

Mei-Chin Hsieh, MSPH, CTR, of LSU Health Sciences Center New Orleans School of Public Health's Louisiana Tumor Registry, is the lead author of a study that reports racial and ethnic differences in the incidence of soft tissue sarcomas in adolescents and young adults.

26 Aug 2013

Scientists Shed New Light On Malignant Pancreatic Cancer

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23 Aug 2013

Scientists identify molecular mechanism that contributes to pancreatic cancer

New research led by scientists at The University of Texas Health Science Center at Houston (UTHealth) and Baylor College of Medicine could aid efforts to diagnose and treat one of the most lethal and hard-to-treat types of cancer.

23 Aug 2013

People exposed to hot environments may develop Malignant hyperthermia

There is mounting evidence that some people who are susceptible to Malignant hyperthermia (MH) will develop MH when exposed to hot environments or with exercise.

22 Aug 2013

Oncopeptides launches phase II study to determine efficacy of melflufen in treatement of multiple myeloma

Oncopeptides AB, a company working to enhance oncology therapies, today announced that the first patient has been dosed as part of a Phase II study in multiple myeloma patients with its drug candidate melflufen (previously called J1).

21 Aug 2013

Multi-site trial shows BI-RADS 3 breast lesions reduce patient anxiety, unnecessary biopsies

Based on data from a multi-site imaging trial involving more than 2,600 women, researchers say breast lesions categorized as 'probably benign' on supplemental screening ultrasound could be re-evaluated with imaging in 12 months, reducing patient anxiety, follow-up exams and unnecessary biopsies. Results of the study are published online in the journal Radiology.

20 Aug 2013

Researchers identify key transcription factor linked with treatment-resistant prostate cancer

Prostate cancer is one of the most common forms of cancer in men and the leading cause of cancer deaths in white, African-American and Hispanic men, according to the Centers for Disease Control. Current treatment of prostate cancer targets androgens, hormones which promote the growth and spread of cancer cells.

20 Aug 2013

Evidence shows bevacizumab therapy improves survival in patients with glioblastoma

A new population-based study has found that patients with glioblastoma who died in 2010, after the Food and Drug Administration (FDA) approval of bevacizumab, had lived significantly longer than patients who died of the disease in 2008, prior to the conditional approval of the drug for the treatment of the deadly brain cancer. Bevacizumab is used to treat patients with certain cancers whose cancer has spread. The study appears in the journal Cancer.

20 Aug 2013

Report demonstrates clinical use of novel biomarker to assess cancer progression, inflammation

A groundbreaking peer reviewed case report by Dr. Isaac Eliaz, M.D. of Amitabha Medical Clinic, demonstrates for the first time the clinical use of novel biomarker galectin-3 to assess cancer progression and inflammation.

19 Aug 2013

New antibodies estimate risk of polyps developing into bowel cancer

Polyps in the mucosa of the colon are a common finding during screening colonoscopies. Some sub-groups of polyps are classed as precursors of bowel cancer. Until now, it has not been possible to precisely estimate the risk of these polyps developing into bowel cancer.

19 Aug 2013

Researchers discover how common oral bacterium can contribute to colorectal cancer

Researchers from Case Western Reserve University School of Dental Medicine have discovered how a common oral bacterium can contribute to colorectal cancer, a finding that opens promising new research avenues for the development of approaches to prevent and treat the disease.

16 Aug 2013

German researchers discover miRNAs, which determine malignancy of urinary bladder cancers

German researchers have identified four biomarkers that correctly determine malignancy of urinary bladder cancers and contribute to the accurate prediction of patient outcomes. Their results are published in the September issue of The Journal of Molecular Diagnostics.

16 Aug 2013

Trinity researchers reveal CHD5 protein acts as tumor suppressor in nervous system development

CHD5 has previously been proposed as a tumour suppressor, acting as a brake that prevents healthy cells from developing into cancer cells. But the part played by the protein in healthy tissue, and whether this role is important for its ability to counter tumour growth, has remained largely uncharted.

14 Aug 2013

Malignant News and Research

FDA approves NDA filing for ibrutinib inhibitor in two B-cell malignancies

Study shows genetic test to classify gastric cancers and match them to therapies offer best outcomes

Report shows women affected by DCIS prefer nonsurgical treatments

Virttu Biologics treats first cohort of patients in SEPREHVIR Phase I/IIa study

Northwestern surgical oncologists use minimally invasive procedure to remove malignant melanoma

Microscopic material in cells offers robust treatment for stroke

Screening strategy for ovarian cancer appears to be highly specific for detecting disease at early stages

Study reports racial, ethnic differences in incidence of soft tissue sarcomas in young adults, adolescents

Scientists Shed New Light On Malignant Pancreatic Cancer

Scientists identify molecular mechanism that contributes to pancreatic cancer

People exposed to hot environments may develop Malignant hyperthermia

Oncopeptides launches phase II study to determine efficacy of melflufen in treatement of multiple myeloma

Multi-site trial shows BI-RADS 3 breast lesions reduce patient anxiety, unnecessary biopsies

Researchers identify key transcription factor linked with treatment-resistant prostate cancer

Evidence shows bevacizumab therapy improves survival in patients with glioblastoma

Report demonstrates clinical use of novel biomarker to assess cancer progression, inflammation

New antibodies estimate risk of polyps developing into bowel cancer

Researchers discover how common oral bacterium can contribute to colorectal cancer

German researchers discover miRNAs, which determine malignancy of urinary bladder cancers

Trinity researchers reveal CHD5 protein acts as tumor suppressor in nervous system development

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