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LouLou Foundation, Penn Med set up Program of Excellence to develop treatments for children with CDKL5

The London-based LouLou Foundation and the Orphan Disease Center of the Perelman School of Medicine at the University of Pennsylvania have established a Program of Excellence to develop effective treatments for children with CDKL5, a rare X-chromosome-linked genetic disorder that causes severe neuro-developmental impairment and early-onset, difficult-to-control seizures.

8 Feb 2016

Scientists identify potential marker for recurring HPV-positive oropharyngeal cancer

A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at The Johns Hopkins University.

7 Feb 2016

Study shows gambling among young teens associated with risk-taking behavior

Gambling among young teens may be associated with increased use of alcohol, cigarettes, or marijuana according to a study that surveyed sixth- to eighth-graders in Italian schools. The research is reported in the February issue of the Journal of Developmental & Behavioral Pediatrics, the official journal of the Society for Developmental and Behavioral Pediatrics.

5 Feb 2016

Discovery takes researchers one step closer to preventing C. diff

Exposure to specific antibiotics is linked to the development of certain strains of antibiotic-resistant C. difficile, one of the fastest growing bacteria superbugs, according to a new study published by Stuart Johnson, MD, of Loyola University Health System, Loyola University Chicago Stritch School of Medicine and the Hines VA Medical Hospital.

5 Feb 2016

Bone loss linked with ALL therapy occurs during first month of treatment

Investigators at Children's Hospital Los Angeles have found that significant bone loss - a side effect of chemotherapy for acute lymphoblastic leukemia (ALL) - occurs during the first month of treatment, far earlier than previously assumed. Results of the study will be available online February 4, in advance of publication in the journal Bone.

5 Feb 2016

Lamin nucleoskeleton disordered in Alzheimer's

Brain cell death in Alzheimer's disease is linked to disruption of a skeleton that surrounds the nucleus of the cells, a researcher in the School of Medicine at The University of Texas Health Science Center at San Antonio said.

5 Feb 2016

Strong link found between incarceration of family members during childhood and heart attacks in men

A parent's incarceration has immediate, devastating effects on a family. Now, Virginia Tech and University of Toronto researchers say there may be a longer term risk: Men who as children experienced a family member's incarceration are approximately twice as likely to have a heart attack in later adulthood in comparison with men who were not exposed to such a childhood trauma.

5 Feb 2016

Duke scientists reveal how gut inflammation increases colon cancer risk

Chronic inflammation in the gut increases the risk of colon cancer by as much as 500 percent, and now Duke University researchers think they know why.

5 Feb 2016

Mercury may not thwart seafood brain benefits

Accumulation of mercury in the brain from eating seafood does not appear to lead to Alzheimer’s disease neuropathology, shows research published in JAMA.

4 Feb 2016

BMPR2 mutations affect outcomes of PAH patients

Mutations in the bone morphogenetic protein receptor type II gene affect not only the risk of developing pulmonary arterial hypertension but also the severity and outcomes of the disease, shows a meta-analysis of individual patient data.

4 Feb 2016

New biosensor test system developed for accurate measurements of protein molecule concentration in blood

Researchers from the General Physics Institute of the Russian Academy of Sciences and Moscow Institute of Physics and Technology have developed a new biosensor test system based on magnetic nanoparticles.

4 Feb 2016

New research identifies key enzyme linked to age-related increases in cancer and inflammation

For the first time, researchers have shown that an enzyme key to regulating gene expression -- and also an oncogene when mutated -- is critical for the expression of numerous inflammatory compounds that have been implicated in age-related increases in cancer and tissue degeneration, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

4 Feb 2016

Potential treatment target identified for fatty liver disease

Two proteins, p38 gamma and p38 delta, control the accumulation of fat in the liver, a process linked to the development of insulin resistance and diabetes, which are common outcomes of obesity. These findings are presented in an article published by researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC).

4 Feb 2016

Genetic variants associated with preference to mornings or nights

23andMe, Inc., the leading personal genetics company, today announced the results of a genome-wide association study (GWAS) identifying genetic variants associated with being a morning person.

3 Feb 2016

'Housekeeping' gene may have a link to male infertility

Researchers at Iowa State University have found evidence that a "housekeeping" gene present in every cell of the body may have a link to male infertility.

3 Feb 2016

Prenatal stress affects babies' health in war-torn areas

Children from war-torn areas of the globe are affected by trauma even before they are born, according to a new University of Florida study.

3 Feb 2016

Innovative mattresses to stop pressure ulcers: an interview with Mike Hutson

Pressure ulcers are wounds that occur when a continuous pressure or friction is placed on one area of the body, damaging the skin. They occur when pressure stops blood from flowing normally, leading the cells to die and the skin to break down.

3 Feb 2016

Study sheds light on mechanisms linked to formation of healthy egg cells in humans

Congenital disorders such as Down's syndrome could be better understood, following new insights into how healthy cells are formed.

3 Feb 2016

Depression symptoms increase risk for heart disease, stroke in middle-aged and older adults

Depression and its symptoms increase as people age, and have been linked to heart disease and stroke in both middle-aged and older adults. But whether depression and its symptoms are risk factors for these two dangerous conditions has been unclear.

2 Feb 2016

Understanding crucial role of 'healthy' brain in preventing memory failures linked to Alzheimer's disease

The mechanisms underlying the stability and plasticity of neural circuits in the hippocampus, the part of the brain responsible for spatial memory and the memory of everyday facts and events, has been a major focus of study in the field of neuroscience. Understanding precisely how a "healthy" brain stores and processes information is crucial to preventing and reversing the memory failures associated with Alzheimer's disease (AD), the most common form of late-life dementia.

2 Feb 2016

X linked News and Research

LouLou Foundation, Penn Med set up Program of Excellence to develop treatments for children with CDKL5

Scientists identify potential marker for recurring HPV-positive oropharyngeal cancer

Study shows gambling among young teens associated with risk-taking behavior

Discovery takes researchers one step closer to preventing C. diff

Bone loss linked with ALL therapy occurs during first month of treatment

Lamin nucleoskeleton disordered in Alzheimer's

Strong link found between incarceration of family members during childhood and heart attacks in men

Duke scientists reveal how gut inflammation increases colon cancer risk

Mercury may not thwart seafood brain benefits

BMPR2 mutations affect outcomes of PAH patients

New biosensor test system developed for accurate measurements of protein molecule concentration in blood

New research identifies key enzyme linked to age-related increases in cancer and inflammation

Potential treatment target identified for fatty liver disease

Genetic variants associated with preference to mornings or nights

'Housekeeping' gene may have a link to male infertility

Prenatal stress affects babies' health in war-torn areas

Innovative mattresses to stop pressure ulcers: an interview with Mike Hutson

Study sheds light on mechanisms linked to formation of healthy egg cells in humans

Depression symptoms increase risk for heart disease, stroke in middle-aged and older adults

Understanding crucial role of 'healthy' brain in preventing memory failures linked to Alzheimer's disease

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