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Molecular inhibitors found to arrest tumor cell proliferation in lung cancer and mesothelioma

Inhibition of the oncogenic kinase AKT, a key protein governing the cell cycle, was found to arrest cancer cell proliferation and triggered their programmed death by apoptosis.

2 Apr 2018

Researchers unravel immunopathogenesis of Johne's disease

A research team has unraveled the immunopathogenesis of Johne's disease, a chronic bovine disease that has caused endemics in Japan and many other countries, placing financial burdens on cattle farmers.

2 Apr 2018

Study reveals how interneurons emerge and diversify in the brain

Modern neuroscience, for all its complexity, can trace its roots directly to a series of pen-and-paper sketches rendered by Nobel laureate Santiago Ramón y Cajal in the late 19th and early 20th centuries.

31 Mar 2018

Researchers propose a novel tripartite mechanism of neural memory

The overwhelming quest in cognitive science has been (and still is) to scientifically describe mental processes on a molecular level, notably memory and intelligence, and attempt to mimic them technologically. But really 'intelligent' computers can only arise from an appreciation of neural reality with credible principles about the nature of neural mentation.

30 Mar 2018

Researchers link teenage driving behaviors to ADHD, other mental health disorders

Teenage drivers ages 16 to 19 are three times more likely to get into fatal accidents than their older counterparts. In this age group, around 20 percent in the United States have been affected by symptoms associated with mental health disorders, including 9 percent with a lifetime history of attention deficit hyperactivity disorder (ADHD).

30 Mar 2018

Adult-onset degenerative disease mechanism begins much earlier than previously thought

The disease mechanism for adult-onset progressive degenerative diseases begins much earlier than previously thought, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

30 Mar 2018

Research reveals role of colon signaling pathway in development of IBD

The intestine encounters more foreign substances, and potential toxins, than other parts of the body, so it is not surprising that a healthy gut is maintained by the tight control of immune responses.

30 Mar 2018

FDA grants accelerated approval to leukemia drug for patients with MRD-positive ALL

The U.S. Food and Drug Administration granted accelerated approval to Blincyto (blinatumomab) to treat adults and children with B-cell precursor acute lymphoblastic leukemia (ALL) who are in remission but still have minimal residual disease (MRD).

30 Mar 2018

First-of-its-kind cancer drug effective in 93% of pediatric patients

A first-of-its-kind drug targeting a fused gene found in many types of cancer was effective in 93 percent of pediatric patients tested, researchers at UT Southwestern's Simmons Cancer Center announced.

30 Mar 2018

Researchers discover major cause of treatment failure in Chagas disease

Researchers at the University of Georgia have discovered that dormancy of the parasite Trypanosoma cruzi prevents effective drug treatment for Chagas disease, which kills more than 50,000 people each year in Central and South America and is a growing threat in the United States and Europe.

30 Mar 2018

Researchers create synthesized nanosheets to inactivate or detect pathogens

Researchers have developed a process for creating ultrathin, self-assembling sheets of synthetic materials that can function like designer flypaper in selectively binding with viruses, bacteria, and other pathogens.

29 Mar 2018

Leukemia itself may increase risk for long-term neurocognitive problems in survivors

Leukemia itself, not just side effects related to its treatment, may increase the risk for long-term problems with attention, organization and related neurocognitive skills in survivors of the most common childhood cancer, according to research from St. Jude Children's Research Hospital. The study appears today in the journal JAMA Oncology.

29 Mar 2018

Researchers reveal molecular structure of 'anti-aging' protein

Researchers from UT Southwestern's Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine's Division of Nephrology recently published work in Nature that reveals the molecular structure of the so-called "anti-aging" protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes.

29 Mar 2018

Salk scientists discover protein that 'turns off' uncontrolled liver cancer growth

Salk Institute scientists, together with researchers from Switzerland's University of Basel and University Hospital Basel, discovered a protein called LHPP that acts as a molecular switch to turn off the uncontrolled growth of cells in liver cancer.

29 Mar 2018

Study shows limitations of AAV gene therapy in treating hereditary adrenal disorders

A new study has definitively shown that a single treatment with gene therapy using adeno-associated viral (AAV) vector gene delivery to replace the defective gene responsible for congenital adrenal hyperplasia (CAH) will only temporarily alleviate the hereditary disorder.

29 Mar 2018

Researchers develop novel approach to fighting ovarian cancer

Researchers have discovered a cellular pathway that selectively regulates a mutant protein linked to the growth of ovarian cancer.

29 Mar 2018

UTSW study reveals mechanisms underlying development of Sonic Hedgehog medulloblastoma

A delicate balance during brain development could have profound implications for understanding and treating medulloblastoma, the most common malignant brain tumor affecting children.

29 Mar 2018

Study identifies potential genetic link in sudden infant death syndrome

Rare genetic mutations associated with impairment of the breathing muscles are more common in children who have died from sudden infant death syndrome (also known as ‘cot death’) than in healthy controls, suggesting a possible genetic element of the disorder, according to a case-control study in the UK and USA published in The Lancet.

29 Mar 2018

Single high-fat meal can set the stage for cardiovascular disease

A single high-fat milkshake, with a fat and calorie content similar to some enticing restaurant fare, can quickly transform our healthy red blood cells into small, spiky cells that wreak havoc inside our blood vessels and help set the perfect stage for cardiovascular disease, scientists report.

29 Mar 2018

UBC researchers unveil representative of most abundant giant viruses in the sea

Bodo saltans virus, the first isolated representative of the most abundant giant viruses in the sea, has been unveiled by researchers at the University of British Columbia.

29 Mar 2018

B Cell News and Research

Molecular inhibitors found to arrest tumor cell proliferation in lung cancer and mesothelioma

Researchers unravel immunopathogenesis of Johne's disease

Study reveals how interneurons emerge and diversify in the brain

Researchers propose a novel tripartite mechanism of neural memory

Researchers link teenage driving behaviors to ADHD, other mental health disorders

Adult-onset degenerative disease mechanism begins much earlier than previously thought

Research reveals role of colon signaling pathway in development of IBD

FDA grants accelerated approval to leukemia drug for patients with MRD-positive ALL

First-of-its-kind cancer drug effective in 93% of pediatric patients

Researchers discover major cause of treatment failure in Chagas disease

Researchers create synthesized nanosheets to inactivate or detect pathogens

Leukemia itself may increase risk for long-term neurocognitive problems in survivors

Researchers reveal molecular structure of 'anti-aging' protein

Salk scientists discover protein that 'turns off' uncontrolled liver cancer growth

Study shows limitations of AAV gene therapy in treating hereditary adrenal disorders

Researchers develop novel approach to fighting ovarian cancer

UTSW study reveals mechanisms underlying development of Sonic Hedgehog medulloblastoma

Study identifies potential genetic link in sudden infant death syndrome

Single high-fat meal can set the stage for cardiovascular disease

UBC researchers unveil representative of most abundant giant viruses in the sea

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