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Lung cancer patients with Del19 mutation benefit most from afatinib

Afatinib has been approved in Germany since September 2013 for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer with activating EGF receptor mutations who have not been treated with an EGF receptor tyrosine-kinase inhibitor (EGFR TKI).

20 Feb 2014

Stress does lead to more headaches, new study reveals

A new study provides evidence for what many people who experience headache have long suspected—having more stress in your life leads to more headaches. The study released today will be presented at the American Academy of Neurology's 66th Annual Meeting in Philadelphia, April 26 to May 3, 2014.

20 Feb 2014

Bayer enrolls patients for Phase III trial of Stivarga (regorafenib) tablets in colorectal cancer

Bayer HealthCare today announced that the company has begun to enroll patients in the COAST trial studying Stivarga® (regorafenib) tablets in colorectal cancer (CRC) patients with resected liver metastases.

20 Feb 2014

Researchers develop screening assay that quickly assesses nearly 1,500 compounds' effect on estrogen

A team of researchers at City of Hope has developed a screening assay that can quickly assess up to 1,536 compounds' effect on estrogen activity in the body. The test can also evaluate whether chemicals act as inhibitors of aromatase, an enzyme linked to breast cancer that converts androgen to estrogen.

20 Feb 2014

Study highlights lack of policies or guidelines regarding wheelchairs and seating provision in Ireland

A study on wheelchair provision, undertaken by the University of Limerick, has highlighted a worrying lack of any national policies or guidelines in support of the 40,000 people who use wheelchairs and seating assistive technology in Ireland.

20 Feb 2014

Purdue’s new innovation improves drug therapies by making real-time decisions about treatment options

Oncologists and cancer patients could improve the results of drug therapies by making real-time decisions about treatment options using an innovation developed in Purdue University's College of Pharmacy.

20 Feb 2014

Researchers examine what dosages of asthma medications works best in African Americans

The University of Illinois at Chicago has received funding from the National Institutes of Health to determine what combination and dosages of asthma medications works best to manage asthma in African Americans, who suffer much higher rates of serious asthma attacks, hospitalizations and asthma-related deaths than do white patients.

20 Feb 2014

Researchers identify switch in brain that sends us off to sleep

The switch in the brain that sends us off to sleep has been identified by researchers at Oxford University's Centre for Neural Circuits and Behaviour in a study in fruit flies.

20 Feb 2014

New method enables scientists to print tissue constructs with blood vessels

A new bioprinting method developed at the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Harvard School of Engineering and Applied Sciences (SEAS) creates intricately patterned 3D tissue constructs with multiple types of cells and tiny blood vessels.

20 Feb 2014

OTC asthma inhaler endangers patients by encouraging substandard treatment

An over-the-counter (OTC) asthma inhaler up for approval by the U.S. Food & Drug Administration (FDA) endangers patients by encouraging substandard treatment, according to Allergy & Asthma Network Mothers of Asthmatics (AANMA), a leading nonprofit patient education and advocacy organization.

20 Feb 2014

Antidepressant medication shows potential in treating symptoms of agitation that occur with AD

An antidepressant medication has shown potential in treating symptoms of agitation that occur with Alzheimer's disease and in alleviating caregivers' stress, according to a multi-site U.S.- Canada study.

20 Feb 2014

Ways to help manage chronic pain

Musculoskeletal pain of the bone, joint and muscles is one of the most common reasons for primary care visits in the United States. According to a literature review appearing in a recent issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS), chronic pain, or pain that persists beyond an expected period of healing, is estimated to affect 100 million Americans.

20 Feb 2014

New biologic drug to prevent growth of ovarian cancer cells

Researchers at Women & Infants Hospital of Rhode Island have developed a biologic drug that would prevent the production of a protein known to allow ovarian cancer cells to grow aggressively while being resistant to chemotherapy. This would improve treatment and survival rates for some women.

20 Feb 2014

Indacaterol/glycopyrronium drug combination offers added benefit for adults with COPD

The drug combination indacaterol/glycopyrronium (trade name: Ultibro Breezhaler, Xoterna Breezhaler) has been approved since September 2013 for adults with chronic obstructive pulmonary disease (COPD).

19 Feb 2014

Researchers explore possible link between metabolic defects and seizures

Researchers from the Franciscan University of Steubenville, Ohio are exploring a possible link between metabolic defects and seizures. They determined that diet could influence susceptibility to seizures, and they have identified a common diabetes drug that could be useful in treating disorders such as epilepsy.

19 Feb 2014

Omeros doses first patient in second Phase 2 clinical trial of OMS824

Omeros Corporation today announced dosing of the first patient in a second Phase 2 clinical trial of OMS824, the company's phosphodiesterase 10 (PDE10) inhibitor being developed for the treatment of schizophrenia, Huntington's disease (HD) and other cognitive disorders. The Phase 2 trial will evaluate the tolerability, safety, pharmacokinetics and performance on a battery of tests in patients with symptomatic HD.

19 Feb 2014

Pairing school and home programs most effective in curbing teen prescription drug abuse

Programs that aim to curb teen prescription drug abuse have vastly differing effectiveness, ranging from big drops in drug abuse to no measurable effect, according to a new study of 11,000 teenagers by researchers at Duke and Pennsylvania State universities.

19 Feb 2014

AlloMap test can be used to assess risk of dysfunction or rejection of a transplanted heart

A new UCLA-led study shows that a blood test commonly used to determine whether heart transplant recipients are rejecting their new organ can also predict potential rejection-related problems in the future.

19 Feb 2014

Antibiotics prescribed for children who have URIs does not prevent complications

Antibiotics are often prescribed for young children who have upper respiratory tract infections (URIs) in order to prevent complications, such as ear infections and pneumonia, however, a new evidence review in The Cochrane Library found no evidence to support this practice.

19 Feb 2014

Neuropsychological assessment efficiently tracks disease progression in memory clinic patients

Investigators at the University of Amsterdam, The Netherlands, have shown that progression of disease in memory clinic patients can be tracked efficiently with 45 minutes of neuropsychological testing. MRI measures of brain atrophy were shown to be less reliable to pick up changes in the same patients.

19 Feb 2014

Drugs News and Research

Lung cancer patients with Del19 mutation benefit most from afatinib

Stress does lead to more headaches, new study reveals

Bayer enrolls patients for Phase III trial of Stivarga (regorafenib) tablets in colorectal cancer

Researchers develop screening assay that quickly assesses nearly 1,500 compounds' effect on estrogen

Study highlights lack of policies or guidelines regarding wheelchairs and seating provision in Ireland

Purdue’s new innovation improves drug therapies by making real-time decisions about treatment options

Researchers examine what dosages of asthma medications works best in African Americans

Researchers identify switch in brain that sends us off to sleep

New method enables scientists to print tissue constructs with blood vessels

OTC asthma inhaler endangers patients by encouraging substandard treatment

Antidepressant medication shows potential in treating symptoms of agitation that occur with AD

Ways to help manage chronic pain

New biologic drug to prevent growth of ovarian cancer cells

Indacaterol/glycopyrronium drug combination offers added benefit for adults with COPD

Researchers explore possible link between metabolic defects and seizures

Omeros doses first patient in second Phase 2 clinical trial of OMS824

Pairing school and home programs most effective in curbing teen prescription drug abuse

AlloMap test can be used to assess risk of dysfunction or rejection of a transplanted heart

Antibiotics prescribed for children who have URIs does not prevent complications

Neuropsychological assessment efficiently tracks disease progression in memory clinic patients

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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