Immune Response News and Research

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Study identifies a protein complex critical for regulating apoptosis and necroptosis

Cell death plays an important role in normal human development and health but requires tightly orchestrated balance to avert disease. Too much can trigger a massive inflammatory immune response that damages tissues and organs. Not enough can interfere with the body's ability to fight infection or lead to cancer.

18 Feb 2022

Early antiretroviral therapy is crucial to fight against HIV and latent tuberculosis

Two weeks makes a big difference in treating the animal version of HIV and latent tuberculosis, researchers from Texas Biomedical Research Institute, Southwest National Primate Research Center and colleagues report this month in the Journal of Clinical Investigation.

18 Feb 2022

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Researchers investigated the connecting link between viral genetic variability and clinical heterogeneity of COVID-19 by analyzing the effect of several missense mutations on the ACE2 receptor coding sequence.

18 Feb 2022

Role of quantitative, multiplexed, targeted proteomics in determining variant-specific SARS-CoV-2 antibody response

Researchers developed a ‘bait and capture’ system which was further followed by a multiplexed and targeted proteomic liquid chromatography-tandem mass spectrometry analyses for the comparison of immune correlates in response to vaccination, natural infection, as well as protection against SARS-CoV-2 variants.

18 Feb 2022

Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

A new study aimed to clarify whether extensive RBD mutations could affect the magnitude and immunodominance hierarchy of the host antibody response.

18 Feb 2022

New finding may aid in development of vaccines against future animal-to-human viral diseases

A future vaccine providing protection against a wide range of coronaviruses that jump from their original animal hosts to humans - including SARS-CoV-2, the cause of COVID-19 - may be possible, say Johns Hopkins Medicine researchers, based on findings from their recent study.

17 Feb 2022

Study shows link between oral microbiome and naturally occurring alveolar bone loss

It is becoming increasingly clear that the human microbiome – the collection of bacteria, viruses and fungi that live on and within us – significantly contributes to our health.

17 Feb 2022

Vaccination likely to be more protective against SARS-CoV-2 viral variants than natural infection

Antibodies generated by COVID-19 vaccines are more suited to recognizing viral variants than antibodies that arise from natural infection, according to a study by researchers at Stanford Medicine.

17 Feb 2022

Gut enzymes open a gateway to create universal blood-type donor organs

A study published in Science Translational Medicine performed at the Latner Thoracic Surgery Research Laboratories and UHN's Ajmera Transplant Centre has proved that it is possible to convert blood type safely in donor organs intended for transplantation.

16 Feb 2022

Antibodies become more powerful for at least six months after COVID-19 vaccination

For at least six months after COVID-19 vaccination, antibodies produced by immune cells become steadily more formidable and more precisely targeted against the virus that causes COVID-19, according to a study of the antibody response to the Pfizer-BioNTech vaccine by researchers at Washington University School of Medicine in St. Louis.

16 Feb 2022

New cholera vaccine generates long-lasting antibody responses in mice

Cholera, a diarrheal disease caused by the highly transmissible bacteria Vibrio cholerae, kills tens of thousands of people each year worldwide.

16 Feb 2022

Study suggests tea polyphenols may modulate COVID-19 via intestinal microbiota

A new study discusses the state of current knowledge about the potential use of tea polyphenols in the prevention and treatment of COVID-19.

16 Feb 2022

Features of platelet-immune crosstalk in healthy recipients of two doses of mRNA-based SARS-CoV-2 vaccine BNT162b2

Researchers investigated the role of platelets in the adverse immune response against a COVID-19 vaccine.

16 Feb 2022

Superior immune response in vaccinated after infection with Omicron compared to unvaccinated

In a recent study posted to the medRxiv* preprint server, researchers evaluated the cross-reactivity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant-triggered neutralization and fragment crystallizable (Fc) effector functions between coronavirus disease 2019 (COVID-19)-vaccinated and unvaccinated individuals in South Africa.

16 Feb 2022

The long-term consequences of SARS-CoV-2 infection in people with HIV

In a recent study posted to the medRxiv* preprint server, an interdisciplinary team of researchers from the United States (US) analyzed a cohort of patients with human immunodeficiency virus (HIV) (PWH) recovering from coronavirus disease 2019 (COVID-19) and characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in these patients.

15 Feb 2022

Immune Response News and Research

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Early antiretroviral therapy is crucial to fight against HIV and latent tuberculosis

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Role of quantitative, multiplexed, targeted proteomics in determining variant-specific SARS-CoV-2 antibody response

Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

New finding may aid in development of vaccines against future animal-to-human viral diseases

Study shows link between oral microbiome and naturally occurring alveolar bone loss

Vaccination likely to be more protective against SARS-CoV-2 viral variants than natural infection

Gut enzymes open a gateway to create universal blood-type donor organs

Antibodies become more powerful for at least six months after COVID-19 vaccination

New cholera vaccine generates long-lasting antibody responses in mice

Study suggests tea polyphenols may modulate COVID-19 via intestinal microbiota

Features of platelet-immune crosstalk in healthy recipients of two doses of mRNA-based SARS-CoV-2 vaccine BNT162b2

Superior immune response in vaccinated after infection with Omicron compared to unvaccinated

The long-term consequences of SARS-CoV-2 infection in people with HIV

Stem cell infusion improves the survival of mice with sepsis

Research suggests SARS-CoV-2 viral accessory proteins may play significant role in viral evolution

Prediction of SARS-CoV-2 epitope candidates for future vaccines

Neutralizing antibody levels to different SARS-CoV-2 epitopes fluctuate over time

Novel combination therapeutic approach could increase survival of pancreatic cancer patients

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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