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Study highlights potential of ASO therapy to treat Fuchs endothelial corneal dystrophy patients

A proof-of-concept study carried out at UCL Institute of Ophthalmology with funding from Fight for Sight has highlighted the potential of a targeted antisense oligonucleotide therapy to treat Fuchs endothelial corneal dystrophy patients with a mutation in the TCF4 gene.

12 Mar 2018

Poorer socioeconomic status linked to lower survival from anal cancer

If you are from a lower income area, your chances of surviving anal cancer are significantly reduced, according to a new study led by investigators at NYU Langone Health's Perlmutter Cancer Center, and publishing online March 12, 2018 in Cancer.

12 Mar 2018

Study provides insights into difficult-to-treat liver diseases

A key cell process that could cause damage to bile ducts and help explain some liver diseases has been identified by scientists.

12 Mar 2018

Researchers report genomic sequencing of 250,000 developmental cells

Researchers from the global Human Cell Atlas Consortium report that they have sequenced a quarter of a million separate cells that are of importance for early development of organs such as the liver, skin and kidneys. Sten Linnarsson at Karolinska Institutet is participating in the project.

9 Mar 2018

Managing eating habits could help control malaria infections, study suggests

Malaria infections might be brought under control by managing the eating habits of infected people or animals, according to a new study.

9 Mar 2018

UIC researchers examine how arsenic affects development of diabetes

A five-year, $2.7 million grant from the National Institute of Environmental Health Sciences will help researchers at the University of Illinois at Chicago answer basic questions about the role of arsenic in the development of diabetes and examine the mechanisms by which selenoproteins - found in the human body in 25 different forms - counter the effects of arsenic.

9 Mar 2018

Researchers develop new method to increase life span of donated brain tissue samples

Researchers at Lund University in Sweden have developed a method that enables them to use donated brain tissue from people with epilepsy for 48 hours. Previously, the researchers only had 12 hours to test new treatments before the structure of the cells started to break down. The research has now been published in the journal Scientific Reports.

9 Mar 2018

New study finds that thirdhand smoke increases lung cancer risk in mice

Researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) identified thirdhand smoke, the toxic residues that linger on indoor surfaces and in dust long after a cigarette has been extinguished, as a health hazard nearly 10 years ago.

9 Mar 2018

Researchers show role for predictive biomarker in neonatal chronic lung disease pathogenesis

Extremely low birth-weight babies are at risk for a chronic lung disease called bronchopulmonary dysplasia, or BPD.

9 Mar 2018

Lower levels of protective molecules could increase heart attack risk in the morning

Cardiovascular disease patients have lower levels of an important family of protective molecules in their blood in the morning, which could be increasing their risk of blood clots and heart attacks at those times, according to early research led by Queen Mary University of London.

9 Mar 2018

Engineers develop optical tool that can read metabolism at subcellular resolution

Metabolic changes in cells can occur at the earliest stages of disease. In most cases, knowledge of those signals is limited, since we usually detect disease only after it has done significant damage. Now, a team led by engineers at Tufts University School of Engineering has opened a window into the cell by developing an optical tool that can read metabolism at subcellular resolution, without having to perturb cells with contrast agents, or destroy them to conduct assays.

9 Mar 2018

Impaired transport processes in neurons contribute to neurodegenerative disorders

Two partners have to find their way to each other in order to transport substances to the remote ends of special nerve fibers to maintain their function. If this partnering process is disturbed, the cells may die in the worst case, resulting in neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) or spinal muscular atrophy.

9 Mar 2018

Modifying Oncolytic Adenoviruses to Target Pancreatic Cancer

Pancreatic cancer is one of the less common but deadliest cancers. Modified oncolytic adenoviruses represent an alternative to chemotherapy and targeted therapies, which have a high mortality rate.

9 Mar 2018

Cycling keeps the body young and healthy

Not surprisingly, a new study has shown that keeping active can keep the body young and healthy. The study comes from the researchers at the University of Birmingham and King's College London who were looking at the health of older adults who had been exercising most of their adult lives. The research has been reported in two papers published this week in the journal Aging Cell.

8 Mar 2018

Researchers find link between increased proteostasis and immortality of stem cells

Stem cells are considered to be immortal in culture and, therefore, of great interest for aging research. This immortality is regulated by increased proteostasis, which controls the quality of proteins.

8 Mar 2018

Newly-discovered hereditary mutation leads to increased production of EPO in the blood

A newly-discovered hereditary mutation is responsible for an increased production of erythropoietin (EPO) in the blood.

8 Mar 2018

Study reveals key function of ALS-linked protein

The protein FUS, whose mutation or disruption causes many cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), works as a central component of one of the most important regulatory systems in cells, according to a new study in Molecular Cell from scientists at Johns Hopkins Bloomberg School of Public Health.

8 Mar 2018

B Cell News and Research

Study highlights potential of ASO therapy to treat Fuchs endothelial corneal dystrophy patients

Poorer socioeconomic status linked to lower survival from anal cancer

Study provides insights into difficult-to-treat liver diseases

Researchers report genomic sequencing of 250,000 developmental cells

Managing eating habits could help control malaria infections, study suggests

UIC researchers examine how arsenic affects development of diabetes

Researchers develop new method to increase life span of donated brain tissue samples

New study finds that thirdhand smoke increases lung cancer risk in mice

Researchers show role for predictive biomarker in neonatal chronic lung disease pathogenesis

Lower levels of protective molecules could increase heart attack risk in the morning

Engineers develop optical tool that can read metabolism at subcellular resolution

Impaired transport processes in neurons contribute to neurodegenerative disorders

Modifying Oncolytic Adenoviruses to Target Pancreatic Cancer

Cycling keeps the body young and healthy

Researchers find link between increased proteostasis and immortality of stem cells

Newly-discovered hereditary mutation leads to increased production of EPO in the blood

Study reveals key function of ALS-linked protein

New study examines origin of cryptococcosis within the central nervous system

Golgi stress signaling pathway found in cells with Huntington’s disease

Research reveals neuroprotective mechanisms of gene and cell medications for spinal cord injuries

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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