Colon News and Research

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Largest data set of cancer-specific genetic variations generated by NCI scientists

Scientists at the National Cancer Institute have generated a data set of cancer-specific genetic variations and are making these data available to the research community, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.

16 Jul 2013

Colorectal cancer survivors at greater risk of developing second cancer: Study

Colorectal cancer survivors face an increased risk of developing subsequent cancers, particularly second colorectal cancers and small intestinal cancers. That is the conclusion of a new study published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

16 Jul 2013

Specific types of intestinal bacteria are major contributors to lymphoma

Researchers from UCLA's Jonsson Comprehensive Cancer Center (JCCC) have discovered that specific types of bacteria that live in the gut are major contributors to lymphoma, a cancer of the white blood cells that are part of the human immune system.

16 Jul 2013

Research roundup: Prevention task force PSA testing recommendations often ignored; Medicaid expansion for minorities; ER and aging population

The authors examined how the growing number of elderly Americans would affect the large and increasing part of non-catastrophic outpatient care. Using Census Bureau and nationally representative survey data, researchers quantified the number of ED visits that would occur if the demographic structure of the U.S. population changed, but everything else remained the same. "We observed that it is actually infants and young adults, not the elderly, who account for the largest number of ED visits," the authors write, and conclude: However, the data do predict increases in visit lengths and the likelihood of hospitalization.

12 Jul 2013

Aflibercept drug shows minor added benefit for overall survival in colorectal cancer patients

The drug aflibercept (trade name: Zaltrap) has been approved in Germany since February 2013 in combination with a certain chemotherapy for adults with metastatic colorectal cancer in whom chemotherapy with oxaliplatin could not stop the disease from progressing.

12 Jul 2013

Tel Aviv researcher says lessons from Israel's health-care system could optimize eye health

According to the World Health Organization, 80% of blindness is preventable or treatable - but it remains a severe health concern across the globe, even in industrialized countries.

11 Jul 2013

Study: Some current Medicaid enrollees may not qualify for benefits that newly enrolled will get

George Washington researchers find that key preventive services included in the health law and slated for millions who will get coverage in the law's Medicaid expansion may not be extended to people already covered by Medicaid.

10 Jul 2013

MerTK inhibition in leukocytes decreases tumor growth and metastasiss

The tyrosine kinase MerTK plays a prominent role in the body's immune response. MerTK signaling helps "calm" the body's first line of immunity, the macrophage, while it performs the routine duties - clearing cells that die and healing damaged tissue.

9 Jul 2013

Research shows hydrogen sulfide is a key player in colon cancer metabolism

University of Texas Medical Branch at Galveston researchers have discovered that hydrogen sulfide - the pungent-smelling gas produced by rotten eggs - is a key player in colon cancer metabolism, and a potential target for therapies for the disease.

9 Jul 2013

Mouse study identifies new treatment options for bowel cancer

Researchers have discovered the genetic processes that cause specific types of bowel cancer. Using this knowledge, they identified cancer drugs that target these genes. Their findings offer the opportunity to develop personalised treatment based on a person's genetic profile.

9 Jul 2013

Soy peptide injection dramatically reduces colon cancer metastasis in mice

After a recent University of Illinois study showed that injection of the soy peptide lunasin dramatically reduced colon cancer metastasis in mice, the researchers were eager to see how making lunasin part of the animals' daily diet would affect the spread of the disease.

9 Jul 2013

Scientists focus on the role of mutated adult neural stem cells play in human diseases

CHARGE syndrome* is a severe developmental disorder affecting multiple organs. It affects 1 in 8500 newborns worldwide. The majority of patients carry a mutation in a gene called CHD7. How this single mutation leads to the broad spectrum of characteristic CHARGE symptoms has been a mystery.

6 Jul 2013

Researchers report that aerobic exercise can lessen or worsen ulcerative colitis symptoms

Aerobic exercise can lessen - or worsen - the symptoms of inflammatory bowel diseases such as ulcerative colitis, depending on the circumstances under which the exercise is undertaken, researchers report.

3 Jul 2013

Study reveals circadian disruption is a risk factor in alcoholic liver disease

Thirty percent of severe alcoholics develop liver disease, but scientists have not been able to explain why only a subset is at risk. A research team from Northwestern University and Rush University Medical Center now has a possible explanation: disrupted sleep and circadian rhythms can push those vulnerable over the edge to disease.

2 Jul 2013

Case Comprehensive Cancer Center secures "outstanding" rating from NCI

The Case Comprehensive Cancer Center (CCCC) again demonstrated the compelling power of partnership in securing an overall rating of "outstanding" and a five-year renewal of its grant from the National Cancer Institute (NCI).

28 Jun 2013

km23-1 protein involved in spread of colon cancer may lead to new treatments for disease

Understanding how the protein km23-1 enables in the spread of colon cancer may lead to new treatments for the disease, according to researchers at Penn State College of Medicine.

28 Jun 2013

Computer simulation for predicting effectiveness of combination therapies for colon tumors

Scientist at Charité - Universitätsmedizin Berlin have used a computer simulation for predicting the effectiveness of various combination therapies for colon tumors. The study has been published in the current issue of the professional journal Molecular Systems Biology*.

28 Jun 2013

Findings suggest BRAF-mutant colon tumor cells may be less sensitive to the effect of aspirin

In 2 large studies, the association between aspirin use and risk of colorectal cancer was affected by mutation of the gene BRAF, with regular aspirin use associated with a lower risk of BRAF-wild-type colorectal cancer but not with risk of BRAF-mutated cancer, findings that suggest that BRAF-mutant colon tumor cells may be less sensitive to the effect of aspirin, according to a study in the June 26 issue of JAMA.

26 Jun 2013

Reason for large increase in hospitalizations of children with IBD unclear, researchers report

The largest investigation to date has found a dramatic increase in the number of hospitalizations for children with inflammatory bowel disease during the past decade in the United States.

26 Jun 2013

Mayo Clinic opens new C. difficile Clinic at Rochester campus

Clostridium difficile (C. difficile) has reached an epidemic state and is the most common infectious cause of diarrhea in hospitals. Health care providers are seeing increased severity and recurrence rates of the infection. In response, Mayo Clinic has opened a C. difficile Clinic at the Rochester campus.

25 Jun 2013

Colon News and Research

Largest data set of cancer-specific genetic variations generated by NCI scientists

Colorectal cancer survivors at greater risk of developing second cancer: Study

Specific types of intestinal bacteria are major contributors to lymphoma

Research roundup: Prevention task force PSA testing recommendations often ignored; Medicaid expansion for minorities; ER and aging population

Aflibercept drug shows minor added benefit for overall survival in colorectal cancer patients

Tel Aviv researcher says lessons from Israel's health-care system could optimize eye health

Study: Some current Medicaid enrollees may not qualify for benefits that newly enrolled will get

MerTK inhibition in leukocytes decreases tumor growth and metastasiss

Research shows hydrogen sulfide is a key player in colon cancer metabolism

Mouse study identifies new treatment options for bowel cancer

Soy peptide injection dramatically reduces colon cancer metastasis in mice

Scientists focus on the role of mutated adult neural stem cells play in human diseases

Researchers report that aerobic exercise can lessen or worsen ulcerative colitis symptoms

Study reveals circadian disruption is a risk factor in alcoholic liver disease

Case Comprehensive Cancer Center secures "outstanding" rating from NCI

km23-1 protein involved in spread of colon cancer may lead to new treatments for disease

Computer simulation for predicting effectiveness of combination therapies for colon tumors

Findings suggest BRAF-mutant colon tumor cells may be less sensitive to the effect of aspirin

Reason for large increase in hospitalizations of children with IBD unclear, researchers report

Mayo Clinic opens new C. difficile Clinic at Rochester campus

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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