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MSK researchers identify a new, rare type of small cell lung cancer

A team of doctors and researchers at Memorial Sloan Kettering Cancer Center (MSK) have identified a new, rare type of small cell lung cancer that primarily affects younger people who have never smoked.

11 Sep 2024

New algorithm unveils key genetic mutations across multiple cancers

A computer algorithm can efficiently find genetic mutations that work together to drive cancer as well as other important genetic clues that researchers might someday use to develop new treatments for a variety of cancers.

11 Sep 2024

Four genes found to significantly influence menopause timing and cancer risk

New research has found four genes with some of the largest known effects on the timing of menopause discovered to date, providing new insight into links between menopause timing and cancer risk.

11 Sep 2024

Study reveals shared and unique molecular markers across multiple forms of dementia

Researchers have for the first time identified degeneration-associated "molecular markers" – observable changes in cells and their gene-regulating networks – that are shared by several forms of dementia that affect different regions of the brain.

11 Sep 2024

Study on Arabidopsis thaliana plants reveals new insights into epigenetic regulation

One of the most fascinating discoveries in biology is that cells have mechanisms for dynamically regulating genetic expression.

11 Sep 2024

Distinct gut bacteria identified in octogenarians linked to aging and health

Research reveals unique gut bacteria in Singaporean seniors, highlighting the microbiome's role in promoting healthier aging and reducing chronic disorders.

11 Sep 2024

TAAR1 gene: A new key to mental health

In the complex landscape of mental health research, a new peer-reviewed Viewpoint review sheds light on an underexplored genetic player: the trace amine-associated receptor 1 (TAAR1). Published in Genomic Psychiatry (ISSN: 2997-2388, Genomic Press, New York), this thought-provoking analysis suggests that mutations in the TAAR1 gene may be a crucial piece of the puzzle in understanding and treating neuropsychiatric disorders.

11 Sep 2024

New insights into the genetics of schizophrenia

In the complex landscape of mental health research, a new peer-reviewed viewpoint offers a critical examination of how genes and environment conspire to influence schizophrenia risk. Published in Genomic Psychiatry (ISSN: 2997-2388, Genomic Press, New York), this thought-provoking analysis by researchers Natassia Robinson and Sarah E. Bergen from Karolinska Institutet in Stockholm, Sweden, brings together cutting-edge findings from genetics and epidemiology.

11 Sep 2024

Addressing the challenges of polycystic kidney disease

Polycystic kidney disease (PKD) is an intractable disorder that causes fluid-filled cysts to grow in the kidneys. It is typically seen in adults. As one of the most prevalent hereditary kidney diseases, the autosomal dominant form of PKD is usually caused by mutations in the PKD1 and PKD2 genes.

11 Sep 2024

Research confirms safety of breastfeeding for breast cancer survivors with BRCA mutations

According to two international studies presented at the ESMO Congress 2024, women who breastfeed after receiving treatment for breast cancer, including those with a germline BRCA mutation (an inherited change in BRCA genes that significantly increases the risk of developing certain cancers, especially breast cancer), do not face an increased risk of recurrence or developing new breast cancers.

9 Sep 2024

Researchers uncover mechanism fueling prostate cancer

Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason why a typically normal protein goes awry and fuels cancer.

9 Sep 2024

New chemical modification reduces off-target effects in siRNA drugs

Small interfering RNA (siRNA) drugs are a class of therapeutic agents that silence specific genes associated with inherited diseases.

9 Sep 2024

Good heart health during early pregnancy may reduce genetic risk of preeclampsia and hypertension

Maintaining good cardiovascular health during the first trimester of pregnancy may offset the genetic risk of developing preeclampsia and/or gestational hypertension, according to preliminary research presented at the American Heart Association's Hypertension Scientific Sessions 2024.

9 Sep 2024

Study shows increased alcohol consumption directly raises dementia risk

Study reveals that higher alcohol consumption, driven by genetic factors, correlates with an increased risk of dementia, challenging the notion that moderate drinking might be protective.

8 Sep 2024

Rethinking cognitive deficits and schizophrenia risk through genetic insights

In a comprehensive review of recent genetic and population studies, published in the peer-reviewed medical journal Genomic Psychiatry (Genomic Press, New York), Professors Michael Owen and Michael O'Donovan of Cardiff University's Centre for Neuropsychiatric Genetics and Genomics present evidence that challenges conventional wisdom about cognitive deficits in schizophrenia

6 Sep 2024

Understanding the cooperation of transcription factors in gene expression

Every cell in our body contains the same DNA, yet liver cells are different from brain cells, and skin cells differ from muscle cells.

6 Sep 2024

Cannabidiol shown to extend lifespan and improve symptoms in Leigh syndrome models

A study led by the UAB Institut de Neurociències and published in the journal Nature Communications demonstrates in animal models how daily administration of cannabidiol (CBD), a substance obtained from the cannabis plant, extends lifespan and improves symptoms associated with Leigh syndrome.

6 Sep 2024

Study reveals key signaling pathways driving lung cancer metastasis

When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS signaling pathways work together to spur the spread of cancer in lung adenocarcinoma, a leading cause of cancer deaths around the world.

6 Sep 2024

Individuals with periodontitis exhibit unique inflammatory protein profile in the blood

Individuals with periodontitis have altered concentrations of various proteins in their blood, according to a new study from Umeå University, Sweden.

6 Sep 2024

Breakthrough technology detects cancer mutant genes with unprecedented sensitivity

Dr. Min-young Lee and Dr. Sung-gyu Park of the Advanced Bio and Healthcare Materials Research Division at KIMS have developed a technology that can detect cancer mutant genes in blood with the world's highest sensitivity of 0.000000001% based on plasmonic nanomaterials for optical signal amplification.

6 Sep 2024