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Trial evaluates purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

Researchers investigated the safety and pharmacokinetics of JNJ-54175446 in a double-blind, multicenter, randomized controlled trial (RCT).

31 Jul 2023

The essential role of the MPL36 protein in leptospirosis

The Leptospira membrane protein L36 (MPL36) is essential for its pathogenesis.

31 Jul 2023

Golgi apparatus may play a role in neuronal circuit reorganization during postnatal brain development

Neurons are the cells that constitute neural circuits and use chemicals and electricity to receive and send messages that allow the body to do everything, including thinking, sensing, moving, and more.

28 Jul 2023

Scientists map 3D structure of kappa opioid receptor

Opioids remain the most potent and effective pain relievers in medicine, but they're also among the most addictive drugs that can halt a person's ability to breathe during an overdose - which can be deadly.

27 Jul 2023

New gene editing approach could revolutionize the treatment of blood disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

27 Jul 2023

Tails on engineered T cells could help fight cancer

In a promising form of immunotherapy known as CAR T-cell (chimeric antigen receptor) therapy, the patient's T cells are engineered to better recognize and attack antigens on the surface of cancer cells.

27 Jul 2023

Study finds that patients with systemic autoimmune rheumatic diseases had a lower antibody response than healthy controls after Omicron infection

Study investigated if patients with systemic autoimmune rheumatic diseases (SARDs) have a reduced immunological response.

27 Jul 2023

COVID-19 treatment: study evaluates ACEi and ARB effects on clinical outcomes

A group of researchers compared the effects of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers.

27 Jul 2023

Researchers discover a protein that plays critical roles in alerting the body to a bacterial infection

A team led by researchers at Massachusetts General Hospital (MGH) has discovered a protein that plays critical roles in alerting the body to a bacterial infection and initiating an effective immune response to fight back against the invasion.

27 Jul 2023

Two infusions of IL-15-expressing CAR NK Cells boost survival in lymphoma mouse models

A new study led by researchers at The University of Texas MD Anderson Cancer Center discovered loss of metabolic fitness in chimeric antigen receptor (CAR) natural killer (NK) cells is a critical mechanism of resistance, with infused cells gradually losing the ability to compete with tumor cells for nutrients, leading to tumor relapse.

26 Jul 2023

Core promoter variation may drive development of triple-negative breast cancer

TNBC is a particularly aggressive subtype of breast cancer, characterized by the absence of three key receptors: estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).

26 Jul 2023

Cervical fibroblasts in cervical insufficiency patients show impaired responses to progesterone

The study described in Scientific Reports highlights an impaired response to the hormone progesterone (P4) in cervical fibroblasts from patients with refractory cervical insufficiency (CI).

26 Jul 2023

Tumor-derived GDF-15 suppresses immunotherapy response

Researchers evaluate the impact of tumor-derived GDF-15 on responses to anti-PD-1 immunotherapy.

26 Jul 2023

Japanese researchers identify genetic quirk linked to severe COVID-19

Despite intensive research since the pandemic began, much remains unknown about COVID-19, particularly why it can be so severe in some cases and relatively mild in others.

25 Jul 2023

Brazilian researchers identify new way to stop excessive inflammation in COVID-19

Researchers at the University of São Paulo (USP) in Brazil have identified a new class of molecules capable of stopping the excessive inflammation typical of the severe form of COVID-19 without impairing the immune response to SARS-CoV-2, the virus that causes the disease.

25 Jul 2023

Receptor News and Research

Trial evaluates purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

The essential role of the MPL36 protein in leptospirosis

Golgi apparatus may play a role in neuronal circuit reorganization during postnatal brain development

Scientists map 3D structure of kappa opioid receptor

New gene editing approach could revolutionize the treatment of blood disorders

Tails on engineered T cells could help fight cancer

Study finds that patients with systemic autoimmune rheumatic diseases had a lower antibody response than healthy controls after Omicron infection

COVID-19 treatment: study evaluates ACEi and ARB effects on clinical outcomes

Researchers discover a protein that plays critical roles in alerting the body to a bacterial infection

Two infusions of IL-15-expressing CAR NK Cells boost survival in lymphoma mouse models

Core promoter variation may drive development of triple-negative breast cancer

Cervical fibroblasts in cervical insufficiency patients show impaired responses to progesterone

Tumor-derived GDF-15 suppresses immunotherapy response

Japanese researchers identify genetic quirk linked to severe COVID-19

Brazilian researchers identify new way to stop excessive inflammation in COVID-19

New targets for psoriasis treatment? Study reveals 165 associated genes

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Unlocking the secrets of asymptomatic COVID-19 infections: HLA-B*15:01 connection revealed

New assay identifies patients with altered p300/CBP acetylation in castration-resistant prostate cancer

Arming phages with heterologous effectors paves the way for successful UTI treatment

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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