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Notch1 and Jagged1 genes are likely markers indicating a patient's probable aggressive breast cancer

In a new study, scientists at The Hospital for Sick Children and Princess Margaret Hospital have shown that two genes called Notch1 and Jagged1 are linked to more aggressive breast cancers and that patients are less likely to survive the disease when these two genes are highly expressed.

26 Sep 2005

New approach to treating brain aneurysm combining the use of intracranial stents and coil embolization

A fender-bender may have saved Douglas Collins' life. A CT scan following the accident discovered Collins, 64, had a brain aneurysm, a weakness in the arterial wall that if ruptured could cause a stroke or death. It was not caused by the accident, but likely could have been a ticking time bomb present for years. The aneurysm was large and previously thought to require open surgery and a lengthy recovery.

26 Sep 2005

Questionnaire helps identify women who have inherited genetic mutations that increase their risk for breast or ovarian cancer

A simplified way for patients to report and update their family medical histories could help identify women who have inherited genetic mutations that increase their risk for breast or ovarian cancer.

26 Sep 2005

Neurologix announces positive interim results of gene therapy clinical trial for patients with Parkinson's disease

Neurologix has announced positive interim results of its landmark gene therapy clinical trial for patients with Parkinson's disease. Neurologix's 12-patient, dose-escalating Phase I trial is the world's first study to use a viral vector (the non-pathogenic adeno-associated virus, or AAV) for the treatment of an adult neurological disease.

26 Sep 2005

PET brain scans of a brain chemical messenger system may prove sensitive enough to help plan brain surgery for epilepsy

When drugs fail to control epilepsy, brain surgery is often the only remaining therapeutic option. However, identifying the correct spot for surgery has traditionally required a separate preliminary -- and inherently risky -- surgical procedure.

26 Sep 2005

Heart disease patients face greater risk of PTSD

Heart attack patients, and most likely those with other forms of heart disease, run an increased risk of developing post-traumatic stress disorder, says a new research review done in Denmark and the Netherlands.

22 Sep 2005

22 biomarkers that provide a more accurate screening for prostate

Researchers at the University of Michigan Comprehensive Cancer Center have identified a panel of 22 biomarkers that together provide a more accurate screening for prostate cancer than the current prostate specific antigen, or PSA, test.

22 Sep 2005

HDL cholesterol helps prevent blocked arteries and heart attack

Cardiology experts at Johns Hopkins have issued interim guidelines for physicians on how best to treat low levels of HDL cholesterol, the so-called good cholesterol, which helps keep arteries clear from the buildup of LDL cholesterol, the so-called bad cholesterol.

22 Sep 2005

Long-term alcoholics are at a higher risk for postoperative infections following elective cardiac surgery

Previous research has shown that post-surgery rates of disease and death are two-to-five times greater among long-term alcoholics than nonalcoholic patients. Of all the possible complications, infection can be the most serious.

22 Sep 2005

First clinical guidelines to help improve the diagnosis and treatment of people with normal pressure hydrocephalus

An international team of medical experts led by a Virginia Commonwealth University researcher has established the first clinical guidelines to help improve the diagnosis and treatment of people with normal pressure hydrocephalus, a debilitating condition in the brain that often goes undiagnosed or is misdiagnosed as Alzheimer's or Parkinson's disease.

21 Sep 2005

Current state of knowledge and experience with vascular birthmarks

The September/October issue of Archives of Facial Plastic Surgery contains several articles on the current state of knowledge and experience with vascular birthmarks, which are caused by blood vessels that do not form correctly.

20 Sep 2005

Periodontal disease develops much earlier than dentists and other health professionals thought

Periodontal disease -- a progressive, eventually painful and disruptive condition in which bacteria attack gums and the hidden roots of teeth -- develops much earlier than dentists and other health professionals thought, a major new study concludes.

20 Sep 2005

Liverpool scientists have found a way of identifying families at high risk of pancreatic cancer

The team has developed a novel means of testing for pancreatic cancer that will enable doctors to treat the killer disease at its earliest stages. They are also now able to show how the risk of cancer for these patients changes with age.

20 Sep 2005

Survey of general surgeons suggests that the amount of education and training they receive in palliative care is limited

Previous studies have indicated that surgeons receive little training in palliative surgical intervention, the objective of which is to relieve symptoms and improve quality of life rather than cure disease or extend survival, according to background information in the article.

20 Sep 2005

Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence

Using a recently developed mouse model of breast cancer, a team from the University of Pennsylvania School of Medicine has shown that Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence.

20 Sep 2005

Public hospital patients are often denied access to Laparoscopic Adjustable Gastric Banding (LAGB) surgery

Public hospital patients are often denied access to one of the most effective forms of weight loss treatment Laparoscopic Adjustable Gastric Banding (LAGB) surgery, a Monash expert says.

19 Sep 2005

PSA remains the best measure of the likelihood of prostate cancer recurrence after surgery

Despite recent claims by some urologists that measuring the blood protein prostate-specific antigen (PSA) may not be effective in predicting risk of prostate cancer, a Johns Hopkins study of more than 2,000 men confirms that PSA remains the best measure of the likelihood of cancer recurrence after surgery.

19 Sep 2005

More than two thirds of meta-analyses available to critical care physicians have major methodological flaws

Research published in Critical Care concludes that the overall quality of meta-analyses in this field is poor, but has improved over time, possibly due to the publication of the Quality of Reporting of Meta-analyses statement (QUOROM) in 1999.

19 Sep 2005

Human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke

Researchers at The University of Texas M. D. Anderson Cancer Center and The University of Texas Health Science Center at Houston have found that human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke.

19 Sep 2005

Does surgery induce angiogenesis in dormant breast cancer?

Analysis of breast-cancer relapse patterns from two independent databases provides indirect evidence for the theory that surgery to remove the primary tumor may initiate formation of a new blood supply (angiogenesis) in formerly dormant metastases, accounting for a pattern of early relapse in younger women.

12 Sep 2005

Surgery News and Research

Notch1 and Jagged1 genes are likely markers indicating a patient's probable aggressive breast cancer

New approach to treating brain aneurysm combining the use of intracranial stents and coil embolization

Questionnaire helps identify women who have inherited genetic mutations that increase their risk for breast or ovarian cancer

Neurologix announces positive interim results of gene therapy clinical trial for patients with Parkinson's disease

PET brain scans of a brain chemical messenger system may prove sensitive enough to help plan brain surgery for epilepsy

Heart disease patients face greater risk of PTSD

22 biomarkers that provide a more accurate screening for prostate

HDL cholesterol helps prevent blocked arteries and heart attack

Long-term alcoholics are at a higher risk for postoperative infections following elective cardiac surgery

First clinical guidelines to help improve the diagnosis and treatment of people with normal pressure hydrocephalus

Current state of knowledge and experience with vascular birthmarks

Periodontal disease develops much earlier than dentists and other health professionals thought

Liverpool scientists have found a way of identifying families at high risk of pancreatic cancer

Survey of general surgeons suggests that the amount of education and training they receive in palliative care is limited

Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence

Public hospital patients are often denied access to Laparoscopic Adjustable Gastric Banding (LAGB) surgery

PSA remains the best measure of the likelihood of prostate cancer recurrence after surgery

More than two thirds of meta-analyses available to critical care physicians have major methodological flaws

Human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke

Does surgery induce angiogenesis in dormant breast cancer?

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