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Gene therapy can reduce painful bleeding episodes in patients with hemophilia B

Symptoms improved significantly in adults with the bleeding disorder hemophilia B following a single treatment with gene therapy developed by researchers at St. Jude Children's Research Hospital in Memphis and demonstrated to be safe in a clinical trial conducted at the University College London (UCL) in the U.K.

12 Dec 2011

PSA testing that combines blood test with other factors can help men avoid prostate biopsies

Prostate cancer screening that combines an adjusted blood test with other factors including the size of the gland, the patient's overall weight and family history, can help up to one-quarter of men avoid biopsies and the risks associated with them, a Beth Israel Deaconess Medical Center-led research team says.

12 Dec 2011

Signal Genetics to launch second generation Myeloma product, MyPRS Plus

Signal Genetics announced today, at the American Society of Hematology Annual Meeting, that the Company is launching its next generation Multiple Myeloma product, MyPRS Plus, effective January 1, 2012.

9 Dec 2011

Increased sensitivity to low frequency vibration found in people with inherited hearing loss

People with a certain form of inherited hearing loss have increased sensitivity to low frequency vibration, according to a study by Professor Thomas Jentsch of the Leibniz-Institut f-r Molekulare Pharmakologie (FMP)/Max Delbr-ck Center for Molecular Medicine (MDC) Berlin-Buch and Professor Gary Lewin (MDC), conducted in cooperation with clinicians from Madrid, Spain and Nijmegen, the Netherlands.

9 Dec 2011

Study explains molecular basis for cherubism disease

The Samuel Lunenfeld Research Institute's Drs. Frank Sicheri, Tony Pawson and Sebastian Guettler, in collaboration with Dr. Robert Rottapel at the Ontario Cancer Institute, have uncovered the detailed architecture of a crucial component of Tankyrase, a protein linked to the bone development disorder cherubism and involved in a myriad of cellular processes.

9 Dec 2011

Researchers reveal contribution of telomerase in controlling genetic code integrity

Researchers have revealed how a molecule called telomerase contributes to the control of the integrity of our genetic code, and when it is involved in the deregulation of the code, its important role in the development of cancer.

9 Dec 2011

'Disinfectants' may reduce risk of E. coli outbreaks

Some E. coli bacteria are harmless and some are dangerous from the outset. Then some become dangerous when they are subjected to viral infection. Researchers are working to find tools that will reduce the risk of this happening.

9 Dec 2011

Study may help personalize pain medication management for sickle cell disease patients

A study that may help personalize pain medication management for sickle cell disease patients is underway at Georgia Health Sciences University.

9 Dec 2011

Ovary removal in younger women may lead to low-bone mineral density, arthritis

Having both ovaries removed before age 45 is strongly associated with low-bone mineral density and arthritis in later years, according to a new study by Johns Hopkins oncologists and epidemiologists. The analysis covered several thousand women who took part in a U.S. government-sponsored, multiyear national health study, and excluded women whose ovaries were removed due to cancer.

9 Dec 2011

Researchers discover potential target for cherubism

Cancer researchers studying genetic mutations that cause leukemia have discovered a connection to the rare disease cherubism, an inherited facial bone disorder in children.

9 Dec 2011

Longer looks: Romney and abortion politics

The heart attacks never came. Four days later, Chris woke up. It was not the awakening of Hollywood movies in which the patient comes to, just as he was, speaking full sentences and completely mobile. Three years later, Chris still cannot talk. Although he breathes on his own, his lungs battle a steady barrage of infections; a feeding tube provides all his sustenance, and his muscles have contracted into short, twisted knots. He can move only the slightest bit. … Still, Wayne and Judy say that his cognition is improving.

9 Dec 2011

Genetically identical Salmonella appear in 2 types, each with an infective advantage

An unusual regulatory mechanism that controls the swimmer/non-swimmer option in genetically identical Salmonella also impacts the bacteria's ability to cause infection.

9 Dec 2011

Scientists uncover three new locations for Crohn's Disease genes

Three new locations for Crohn's Disease genes have been uncovered by scientists at UCL using a novel gene mapping approach.

9 Dec 2011

Breast cancer risks and management updates

A new report that looks at the environmental factors that affect risk of breast cancer is out. It suggests that women can reduce their risk by avoiding unnecessary medical radiation, forgoing hormone treatments for menopause that combine estrogen and progestin, limiting alcohol intake and minimizing weight gain.

8 Dec 2011

Recommendations to address challenges associated with chronic inflammatory diseases

A dramatic increase in the incidence of chronic inflammatory diseases such as asthma, allergy, and irritable bowel syndrome, has led to concern about how modern lifestyles may trigger physiological defense mechanisms.

8 Dec 2011

Considering varying extent to which genes are turned on or off can help develop personalised, predictive medicines

The vast majority of genetic disorders (schizophrenia or breast cancer, for example) have different effects in different people. Moreover, an individual carrying certain mutations can develop a disease, whereas another one with the same mutations may not. This holds true even when comparing two identical twins who have identical genomes. But why does the same mutation have different effects in different individuals?

8 Dec 2011

Federal officials push greater medical use of gene sequencing

Almost a year after researchers in Wisconsin published a groundbreaking paper describing their use of genetic sequencing to diagnose and treat a 4-year-old boy, a national health agency is shifting its focus to put $416 million into making the secrets of our genetic script part of standard medical practice.

8 Dec 2011

New gene editing technique can heal sickle cell patients with their own cells

Researchers at the Salk Institute for Biological Studies have developed a way to use patients' own cells to potentially cure sickle cell disease and many other disorders caused by mutations in a gene that helps produce blood hemoglobin.

8 Dec 2011

Researchers determine planar nets to build self-assembling 3-D structures

Material chemists and engineers would love to figure out how to create self-assembling shells, containers or structures that could be used as tiny drug-carrying containers or to build 3-D sensors and electronic devices.

8 Dec 2011

Massive and consistent changes in inflammatory gene expression seen in trauma, burns

Serious traumatic injuries, including major burns, set off a "genomic storm" in human immune cells, altering around 80 percent of the cells' normal gene expression patterns. In a report to appear in the December Journal of Experimental Medicine, members of a nationwide research collaborative describe the initial results of their investigation into the immune system response to serious injury, findings which have overturned some longstanding assumptions.

8 Dec 2011

Genetic News and Research

Gene therapy can reduce painful bleeding episodes in patients with hemophilia B

PSA testing that combines blood test with other factors can help men avoid prostate biopsies

Signal Genetics to launch second generation Myeloma product, MyPRS Plus

Increased sensitivity to low frequency vibration found in people with inherited hearing loss

Study explains molecular basis for cherubism disease

Researchers reveal contribution of telomerase in controlling genetic code integrity

'Disinfectants' may reduce risk of E. coli outbreaks

Study may help personalize pain medication management for sickle cell disease patients

Ovary removal in younger women may lead to low-bone mineral density, arthritis

Researchers discover potential target for cherubism

Longer looks: Romney and abortion politics

Genetically identical Salmonella appear in 2 types, each with an infective advantage

Scientists uncover three new locations for Crohn's Disease genes

Breast cancer risks and management updates

Recommendations to address challenges associated with chronic inflammatory diseases

Considering varying extent to which genes are turned on or off can help develop personalised, predictive medicines

Federal officials push greater medical use of gene sequencing

New gene editing technique can heal sickle cell patients with their own cells

Researchers determine planar nets to build self-assembling 3-D structures

Massive and consistent changes in inflammatory gene expression seen in trauma, burns

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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