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What does the Future of Microfluidics within Research Look Like?

We speak to France Hamber, CEO of Fluigent, about their microfluidics solutions and how they are allowing scientists to focus more on the science than the setup.

From Fluigent 11 Apr 2022

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

In a recent study posted to the bioRxiv* preprint server, researchers developed aminoadamantane nitrates compounds that inhibit the ion channels formed by the envelope (E) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enable targeted drug delivery of nitric oxide (NO)-related group for S-nitrosylation of host angiotensin-converting enzyme 2 (ACE2), which would inhibit ACE2 binding with the viral spike (S) protein and thereby inhibit viral replication in the host.

11 Apr 2022

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

In a recent article published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers reviewed the present-day therapeutic landscape of coronavirus disease 2019 (COVID-19) and addressed future opportunities to overcome challenges that hinder drug development and improve the global preparedness for future pandemics.

10 Apr 2022

Computational network science approach reveals new mechanisms for coronaviruses infections

A group of bat viruses related to SARS-CoV-2 can also infect human cells but uses a different and unknown entryway.

8 Apr 2022

Substantial SARS-CoV-2 infection in perivascular cells of inflamed blood vessels

A new study demonstrated that vascular inflammation leads to heightened SARS-CoV-2 infection in perivascular cells.

8 Apr 2022

Evaluating immunogenicity after BNT162b2 booster vaccination

Researchers assessed the levels of IgG and IgA antibodies in sera samples from healthcare workers before vaccination, after the first vaccine dose, after eight months, and after a booster shot.

8 Apr 2022

Study characterizes SARS-CoV-2 spike-specific cluster of differentiation 4+ T-cell response

In a new study, researchers characterized over 100 SARS-CoV-2-specific CD4+ T-cell epitopes.

8 Apr 2022

Improved seroprevalence and antibody response after third COVID-19 vaccination

Researchers evaluated the immunogenicity of a third COVID-19 vaccination in antibody deficient subjects.

8 Apr 2022

UGA researchers develop nanotechnology-based optical sensors for rapid coronavirus detection

A University of Georgia nanotechnology research group entered the race to develop a rapid test for COVID-19 in August 2020, running experiments on a new sensor for an American manufacturing company.

7 Apr 2022

Study suggests blunted serological responses not responsible for COVID-19 mortality

A new study investigated serological profiling to determine the antibody responses in critically ill COVID-19 positive and negative patients.

7 Apr 2022

Molecular signature of highly stereotyped clonotypic anti-PF4 antibodies indicates shared pathways of antibody production in VITT patients

A recent study analyzed the antibody that mediated the COVID-19 vaccine-induced thrombotic thrombocytopenia.

7 Apr 2022

Study explores broad-spectrum, host-acting antiviral strategy to treat SARS-CoV-2

A new study investigates the combination of two small molecules that target the host cells and reports a synergistic antiviral activity in vitro against SARS-CoV-2.

7 Apr 2022

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

A recent article presented the diverse pathogenesis of SARS-CoV-2 variants of concern in a humanized mouse model.

7 Apr 2022

Severe COVID linked to RAAS and hyperlipidemia associated metabolic syndrome conditions

A recent study posted to the medRxiv* preprint server investigated the association of renin-angiotensin-aldosterone system (RAAS)-mediated hypertension (HT) with coronavirus disease 2019 (COVID-19).

6 Apr 2022

COVID boosters protect you better than monoclonal antibodies, or natural infection

In a new study published in the journal Science Translational Medicine, researchers analyzed the neutralization of the Omicron BA.1 variant pseudovirus by post-vaccination serum samples.

6 Apr 2022

Researchers discover over 40 new genetic markers for Alzheimer’s disease

A new Nature Genetics study describes over 70 gene markers that appear to be significantly associated with AD risk using translational genomics.

6 Apr 2022

Researchers demonstrate how a narrow-spectrum antibiotic selectively targets C. diff

Most antibiotics are double-edged swords. Besides killing the pathogen they are prescribed for, they also decimate beneficial bacteria and change the composition of the gut microbiome.

6 Apr 2022

Investigating high rate of Omicron sublineage breakthrough infections in triple vaccinated healthcare workers

Researchers identified breakthrough infections by Omicron sublineages BA.1, BA.1.1, and BA.2 in triple-vaccinated healthcare workers of Sweden.

6 Apr 2022

Insights into the pathophysiology of NeuroCOVID

A new study describes the neurological features of COVID-19, both short- and long-term.

6 Apr 2022

Researchers explore the link between immunoglobulins and blood profile in severe SARS-CoV-2 patients

A new study illustrated the association of immunoglobulins with blood characteristics in COVID-19 patients.

6 Apr 2022

Enzyme News and Research

What does the Future of Microfluidics within Research Look Like?

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

Computational network science approach reveals new mechanisms for coronaviruses infections

Substantial SARS-CoV-2 infection in perivascular cells of inflamed blood vessels

Evaluating immunogenicity after BNT162b2 booster vaccination

Study characterizes SARS-CoV-2 spike-specific cluster of differentiation 4+ T-cell response

Improved seroprevalence and antibody response after third COVID-19 vaccination

UGA researchers develop nanotechnology-based optical sensors for rapid coronavirus detection

Study suggests blunted serological responses not responsible for COVID-19 mortality

Molecular signature of highly stereotyped clonotypic anti-PF4 antibodies indicates shared pathways of antibody production in VITT patients

Study explores broad-spectrum, host-acting antiviral strategy to treat SARS-CoV-2

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

Severe COVID linked to RAAS and hyperlipidemia associated metabolic syndrome conditions

COVID boosters protect you better than monoclonal antibodies, or natural infection

Researchers discover over 40 new genetic markers for Alzheimer’s disease

Researchers demonstrate how a narrow-spectrum antibiotic selectively targets C. diff

Investigating high rate of Omicron sublineage breakthrough infections in triple vaccinated healthcare workers

Insights into the pathophysiology of NeuroCOVID

Researchers explore the link between immunoglobulins and blood profile in severe SARS-CoV-2 patients

Understanding the DNA Damage Response in Innate Immunity eBook

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