Protein C News and Research

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"One-two punch" disables tumors' defenses

An aggressive form of breast cancer known as "triple negative" is very difficult to treat: Chemotherapy can shrink such tumors for a while, but in many patients they grow back and gain resistance to the original drugs.

25 Oct 2013

Whitehead Institute scientists identify novel Parkinson's disease drug target

Using a discovery platform whose components range from yeast cells to human stem cells, Whitehead Institute scientists have identified a novel Parkinson's disease drug target and a compound capable of repairing neurons derived from Parkinson's patients.

25 Oct 2013

Scientists identify link between rare mutations in RINT1 gene and early onset breast cancer risk

An international team of scientists has identified an association between heritable, rare mutations in the RINT1 gene and increased risk of early onset breast cancer, according to research reported today (Oct. 24) at the American Society of Human Genetics 2013 annual meeting in Boston.

25 Oct 2013

DSM, Sanquin Make Factor IX-Recovering Mab Manufacturing Deal

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24 Oct 2013

Common food additive can block new strain of avian influenza virus

A common food additive can block a deadly new strain of avian influenza virus from infecting healthy cells, report researchers at the University of Illinois at Chicago College of Medicine in the online journal, PLOS ONE.

24 Oct 2013

Study shows plant sterols appear to prevent onset of Alzheimer's disease

It's no secret that many of the phytochemicals in fruit and vegetables have a positive effect on our health. For instance, plant sterols (also known as phytosterols) help to lower cholesterol levels. According to a new study by researchers at Saarland University, they also appear to prevent the onset of Alzheimer's disease.

24 Oct 2013

BUSM researchers capture images of channels that direct proteins to right place in cell membranes

Similar to passengers on an urban transit system, every protein made in the cell has a specific destination and function. Channels in cell membranes help direct these proteins to their appropriate target. Researchers at Boston University School of Medicine and their colleagues have now captured images of these channels as they open to allow proteins to pass through a membrane, while the proteins are being made.

24 Oct 2013

Activation mechanism of protective protein in ocular lens resolved

The lens of the human eye is made up of a highly concentrated protein solution that imparts the eye its high refractive power. Yet, despite this high protein content the ocular lens must remain clear and transparent.

24 Oct 2013

Diffregen awarded SBIR Phase 1 grant to advance Angiocidin towards human clinical trials

Diffregen LLC, a Temple University startup company, has been awarded a small business innovation research Phase 1 grant by the National Cancer Institute to advance Angiocidin, a university-created therapeutic to treat acute myeloid leukemia, to the doorstep of human clinical trials.

24 Oct 2013

Study uncovers new genetic pathways that could revolutionise acute dendritic leukaemia treatment

Acute dendritic leukaemia is a rare type of leukaemia, but one with the worst prognosis-the average patient survival rate is just 12-14 months-that is difficult to treat. Juan Cruz Cigudosa's team, from the Spanish National Cancer Research Centre's Molecular Cytogenetics Group, has for the first time sequenced the exome -the coding, or protein-generating, regions of the genome- of dendritic cell leukaemia.

24 Oct 2013

Testosterone treatment in hypogonadal men may reduce cardiovascular disease risk

Research from Boston University School of Medicine suggests that testosterone treatment in hypogonadal (testosterone deficient) men restores normal lipid profiles and may reduce the risk of cardiovascular disease. These finding currently appear online in the International Journal of Clinical Practice.

24 Oct 2013

Researchers describe why current medications only moderately reduce Fragile X symptoms

When you experience something, neurons in the brain send chemical signals called neurotransmitters across synapses to receptors on other neurons. How well that process unfolds determines how you comprehend the experience and what behaviors might follow. In people with Fragile X syndrome, a third of whom are eventually diagnosed with Autism Spectrum Disorder, that process is severely hindered, leading to intellectual impairments and abnormal behaviors.

24 Oct 2013

Researchers explore the origin of sweat gland stem cells

Without sweat, we would overheat and die. In a recent paper in the journal PLOS ONE, USC faculty member Krzysztof Kobielak and a team of researchers explored the ultimate origin of this sticky, stinky but vital substance - sweat gland stem cells.

24 Oct 2013

Newly discovered proteins in spinal fluid can serve as markers for Alzheimer's disease

23 Oct 2013

Researchers uncover mechanism for improving song learning in juvenile zebra finches

Most songbirds learn their songs from an adult model, mostly from the father. However, there are relatively large differences in the accuracy how these songs are copied.

23 Oct 2013

A simple blood test may reveal the earliest signs of pancreatic cancer

Reporting on a small preliminary study, Johns Hopkins researchers say a simple blood test based on detection of tiny epigenetic alterations may reveal the earliest signs of pancreatic cancer, a disease that is nearly always fatal because it isn't usually discovered until it has spread to other parts of the body.

23 Oct 2013

Protein C News and Research

"One-two punch" disables tumors' defenses

Whitehead Institute scientists identify novel Parkinson's disease drug target

Scientists identify link between rare mutations in RINT1 gene and early onset breast cancer risk

DSM, Sanquin Make Factor IX-Recovering Mab Manufacturing Deal

Common food additive can block new strain of avian influenza virus

Study shows plant sterols appear to prevent onset of Alzheimer's disease

BUSM researchers capture images of channels that direct proteins to right place in cell membranes

Activation mechanism of protective protein in ocular lens resolved

Diffregen awarded SBIR Phase 1 grant to advance Angiocidin towards human clinical trials

Study uncovers new genetic pathways that could revolutionise acute dendritic leukaemia treatment

Testosterone treatment in hypogonadal men may reduce cardiovascular disease risk

Researchers describe why current medications only moderately reduce Fragile X symptoms

Researchers explore the origin of sweat gland stem cells

Newly discovered proteins in spinal fluid can serve as markers for Alzheimer's disease

Researchers uncover mechanism for improving song learning in juvenile zebra finches

A simple blood test may reveal the earliest signs of pancreatic cancer

Novozymes, Almac Ally To Offer Drug Targeting, Pharmacokinetics Service

Promising technique for treating eye disease proves effective in preclinical studies

eXtasy software suite quickly and accurately traces origins of genetic disorders

Fatty acid entry into cells happens by diffusion

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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