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Allowing the heart to rest can reverse structural changes in myocytes after heart failure

Structural changes in heart muscle cells after heart failure can be reversed by allowing the heart to rest, according to research at Imperial College London. Findings from a study in rats published today in the European Journal of Heart Failure show that the condition's effects on heart muscle cells are not permanent, as has generally been thought. The discovery could open the door to new treatment strategies.

2 Apr 2012

Studies use three genes to reprogram fibroblasts into myocytes

The latest research developments to reprogram scar tissue resulting from myocardial infarction (MI) into viable heart muscle cells, were presented at the Frontiers in CardioVascular Biology (FCVB) 2012 meeting, held 30 March to 1 April at the South Kensington Campus of Imperial College in London.

2 Apr 2012

RNA binding motif protein 20 regulates titin splicing

Cardiomyopathy comprises a deterioration of the heart muscle that affects the organ's ability to efficiently pump blood through the body. Previously researchers have tied forms of the disease to the alternative splicing of titin, a giant protein that determines the structure and biomechanical properties of the heart, but the molecular mechanism remained unknown.

2 Apr 2012

New guidelines offer guidance on how and when to switch between RA drug classes

A trend toward more aggressive treatment in patients just starting to develop rheumatoid arthritis is among the most important changes in treatment guidelines for the disease, according to updated American College of Rheumatology recommendations published today in the journal Arthritis Care & Research. The trend may proceed from emerging opinions that joint damage caused by RA is irreversible, and that early, intensive therapy better preserves physical function, quality of life and capacity to work.

2 Apr 2012

Hypoxia in tumors can predict prostate cancer recurrence in men

Low oxygen levels in tumors can be used to predict cancer recurrence in men with intermediate-risk prostate cancer even before they receive radiation therapy.

2 Apr 2012

Study shows how fat cells can protect the body against diabetes

In a finding that may challenge popular notions of body fat and health, researchers at Beth Israel Deaconess Medical Center (BIDMC) have shown how fat cells can protect the body against diabetes. The results may lead to a new therapeutic strategy for preventing and treating type 2 diabetes and obesity-related metabolic diseases, the authors say.

2 Apr 2012

Nasal spray to prevent fat and plaque built up in the heart on the horizon

Researchers found a treatment that was much more effective in removing fat from arteries than established methods. The vaccine can be given as an injection or in a slightly different form as a nasal spray. A trial on 144 heart disease sufferers is under way in the US and Canada.

1 Apr 2012

Obesity drugs need more heart safety scrutiny: FDA panel

According to federal advisors last Thursday, obesity drugs should undergo clinical trials to ensure that they do not cause heart attacks. This would make it harder for these drugs to receive approval.

1 Apr 2012

Synthetic Marijuana banned in NY

Brands like “Mr. Nice Guy”, “Smiley Dog”, “K2”, “Spice”, “Galaxy Gold” and other brands of fake pot sold across the counter in convenience stores and tobacco shops face the ban. The ban was issued by New York State Health Commissioner Nirav Shah and his New York City equivalent with immediate effect.

1 Apr 2012

Johns Hopkins Hospital's new home to open on May 1

The Johns Hopkins Hospital's new home, set to open on May 1, will redefine the very essence of the hospital experience, and cutting-edge technology designed to improve care, streamline workflow and encourage efficiencies will play a central role.

31 Mar 2012

Sleep deprivation does not disturb performance of interventionists during PCI procedures

A single-center study found that percutaneous coronary intervention (PCI) procedures performed during the middle of the night do not adversely affect the safety and effectiveness of procedures performed the next day by the same operator.

31 Mar 2012

Perspectives: All this fuss about the word 'tax'; Civic lessons from the Supreme Court

It is now clear that the law will impose heavy burdens on state and family budgets and increasingly possible that its mandate that all Americans purchase health insurance or face penalties will be ruled unconstitutional. ... We and our Republican colleagues voted against the law two years ago and will continue to work toward a smarter, step-by-step solution that will make health care available to more Americans at a lower cost to the federal government, the states, and individuals seeking care.

31 Mar 2012

HHS Secretary announces six winners in HHSinnovates program

Health and Human Services (HHS) Secretary Kathleen Sebelius announced six winners in the HHSinnovates program today in a ceremony at HHS headquarters, saying all the entries "show a vibrant culture of innovation" within the department.

31 Mar 2012

Starvation during childhood may increase risk of heart complications

Russians born during the Leningrad Siege in World War II, which was responsible for some of the greatest losses of civilian life in history, are giving scientists new strategies to identify people who experienced intrauterine growth restriction (IUGR) and starvation during childhood at greatest risk of developing long term heart complications.

31 Mar 2012

Cambridge Heart fourth quarter total revenue decreases to $557,000

Cambridge Heart, Inc., a developer of non-invasive diagnostic tests for cardiac disease, today reported results for its fourth quarter and full year ended December 31, 2011. Full financial statements and corresponding commentary can be found in the Company's Form 10-K, which will be filed with the Securities and Exchange Commission on March 30, 2012.

31 Mar 2012

Nile Therapeutics to sell 3.6 million shares of common stock

Nile Therapeutics, Inc., a biopharmaceutical company that develops novel therapeutics for heart failure patients, today announced that it has entered into a definitive agreement to sell 3.6 million shares of its common stock at a price per share of $0.40 for aggregate gross proceeds of $1.44 million.

31 Mar 2012

Bionovo 2011 total revenues decrease to $0.3 million

Bionovo, Inc., a pharmaceutical company focused on the discovery and development of safe and effective treatments for women's health and cancer, today announced financial results for the year ended December 31, 2011.

31 Mar 2012

Birth weight may identify future metabolic risks in girls

Heavier female babies are more likely to develop diabetes and related metabolic risks when they grow up compared with their male counterparts, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology and Metabolism.

30 Mar 2012

Paying doctors and hospitals for better outcomes may not pay off

Medicare's largest effort to pay bonuses to hospitals that hit key performance measures -- or dock them if they miss -- did not lead to fewer deaths for heart attacks and heart bypass surgery, a new study finds. The analysis could lead to a reexamination of the idea of paying providers based on quality metrics, rather than on volume, which is key to the health law.

30 Mar 2012

Marfan syndrome researcher to receive March of Dimes/Colonel Harland Sanders Award

A long-time clinician and researcher on Marfan syndrome who helped identify the syndrome's genetic cause and a potential treatment will be honored by the March of Dimes.

30 Mar 2012