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Antidepressants in pregnancy do not cause autism, study finds

New research cannot establish a close connection between the use of antidepressant medication - the so-called SSRIs - during the course of pregnancy and the risk of having a child with autism.

25 Nov 2013

CHMP recommends approval of Otsuka's Deltyba for pulmonary multidrug-resistant tuberculosis

Otsuka Pharmaceutical Co., Ltd. today announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended approval of Deltyba (delamanid) in combination with a WHO recommended optimized background regimen for the treatment of pulmonary multidrug-resistant tuberculosis (MDR-TB). The CHMP opinion will help form the basis for a European Commission decision expected early next year.

25 Nov 2013

Study shows X-ray lasers can generate complete 3-D model of protein from scratch

A study shows for the first time that X-ray lasers can be used to generate a complete 3-D model of a protein without any prior knowledge of its structure.

25 Nov 2013

NEXAVAR tablets receive FDA approval for treatment of patients with thyroid cancer

Bayer HealthCare and Onyx Pharmaceuticals, Inc., an Amgen subsidiary, today announced that the U.S. Food and Drug Administration has approved a supplemental New Drug Application for the oral multi-kinase inhibitor NEXAVAR (sorafenib) tablets for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma refractory to radioactive iodine treatment.

23 Nov 2013

New bill offers hope to HIV patients on transplant waiting lists

A bill scheduled to be signed into law today by President Obama reverses the longtime ban on letting HIV-infected people donate their organs for transplantation after death, a move that offers hope to thousands of HIV patients on transplant waiting lists.

22 Nov 2013

Sinai Hospital reports results from Phase 2a trial of apo A-I infusion therapy CSL112

Researchers from the Sinai Center for Thrombosis Research presented findings from a Phase 2a trial substudy that examined the antiplatelet effects of CSL112, a novel apolipoprotein A-I (apo A-I) infusion therapy, at the American Heart Association 2013 Scientific Sessions.

22 Nov 2013

New documentary reveals how antiretroviral therapy transformed lives of HIV people in Africa

A new documentary produced by the University of East Anglia reveals how the lives of people with HIV in Africa have been transformed by antiretroviral therapy and highlights the crucial need for continued funding of the lifesaving treatment.

22 Nov 2013

Mouse study highlights importance of microorganisms in optimal cancer treatment outcomes

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22 Nov 2013

EYLEA Injection gets approval in Japan for treatment of macular edema following CRVO

Regeneron Pharmaceuticals, Inc. today announced that EYLEA (aflibercept) Injection has received approval for the treatment of Macular Edema Following Central Retinal Vein Occlusion from the Japanese Ministry of Health, Labour and Welfare.

22 Nov 2013

Scientists hope to find new treatments for traumatic brain injury

In the most wide-reaching project of its kind, scientists at the University of Texas Medical Branch are expanding their research on traumatic brain injury, examining its progressive, chronic effects on the body in hopes of treating its immediate and long-term consequences. The project is funded by a three-year, $9 million grant from The Moody Foundation of Galveston.

22 Nov 2013

Longer looks: Parents' crusade on rare diseases; fighting obesity; experts' view of alternative medicine

In the beginning, Chris Hempel noticed the clumsiness. Her girls tripped over toys on the floor. Their grandfather said he couldn't teach them to pedal their tricycles. … The Hempels learned of people who called themselves citizen-scientists. Many shared research papers and their day-to-day experience. Some talked of their willingness to try any promising drug. Others sought a role as equal partners with researchers. Scientists, while sympathetic, generally believe their work should be left to experts. Families are encouraged to raise money if they want to help, but the traditional view is that amateurs can't shape research or find cures. The Hempels found a maddening gap between the search for scientific knowledge and the search for treatments (Amy Docker Marcus, 11/2013).

22 Nov 2013

Targeting single enzyme in the obese could help prevent and treat diabetes

A single overactive enzyme worsens the two core defects of diabetes—impaired insulin sensitivity and overproduction of glucose—suggesting that a drug targeting the enzyme could help correct both at once, according to mouse studies done by researchers at Columbia University Medical Center. The findings were published today in the online edition of Cell Metabolism.

22 Nov 2013

Research paves way towards personalized chronotherapy treatments

Cancer chronotherapy consists in administering treatment at an optimal time. Because the body is governed by precise biological rhythms, the efficacy of anti-cancer drugs can be doubled and their toxicity reduced five-fold depending on the exact timing of their administration.

22 Nov 2013

Brown fat stem cells may lead to new treatments for heart and endocrine disorders

Obesity and diabetes have become a global epidemic leading to severe cardiovascular disease. Researchers at the University of Utah believe their recent identification of brown fat stem cells in adult humans may lead to new treatments for heart and endocrine disorders, according to a new study published in the peer-reviewed journal Stem Cells.

22 Nov 2013

Researchers identify a group of 39 genes linked with alcoholism

There is good evidence from studies of families and twins that genetics plays an important role in the development of alcoholism. However, hundreds of genes likely are involved in this complex disorder, with each variant contributing only a very small effect. Thus, identifying individual risk genes is difficult.

21 Nov 2013

Combinatory therapy may be effective in suppressing drug resistance in treatment of melanoma

Stand Up To Cancer (SU2C), the charitable initiative supporting ground-breaking research aimed at getting new cancer treatments to patients in an accelerated timeframe, announces that the Allan H. (Bud) and Sue Selig Stand Up To Cancer Melanoma Innovative Research Grant Recipient Roger S. Lo, M.D., Ph.D., associate professor in the Department of Medicine at the Jonsson Comprehensive Cancer Center of the University of California, Los Angeles (UCLA) has published two studies in Cancer Discovery, a journal of the American Association for Cancer Research which indicate that treatment using combinatory therapy may be effective in suppressing drug resistance in the treatment of melanoma.

21 Nov 2013

Research: New drugs show ability to rapidly shrink melanoma tumors

Melanoma is the deadliest form of skin cancer, killing more than 8,000 in the U.S. each year. Approximately 40 percent of advanced melanoma tumors are driven to grow by the presence of mutations in a gene known as the BRAF gene.

21 Nov 2013

Antibiotic resistance holds stable in U.S. children's hospitals

Two studies published in the December issue of Infection Control and Hospital Epidemiology show antibiotic resistance patterns for children have held stable over a seven-year period and surgical patients in U.S. children's hospitals account for 43 percent of all antibiotic use in children's hospitals, presenting an opportunity for targeted intervention.

21 Nov 2013

Study: Patients staying on medications does not lower hospital readmission rates

A targeted effort to help high-risk heart failure patients stay on their medications did improve adherence to drug regimens, but had surprisingly little effect lowering hospital readmission rates, according to a study at Duke Medicine.

21 Nov 2013

Expiring patents, austerity measures lead to predictions that prescription drug sales will continue to slow

Growth in global prescription drug spending will slow to the lowest rate in decades as low-cost generic drugs continue replacing former blockbusters in the U.S. and Europe, where governments face new pressure to reduce health care spending, according to a new forecast. The projection from data firm IMS Health shows the global prescription drug market growing by 3 to 6 percent over the next four years to $1.2 trillion by 2017.

21 Nov 2013

Drugs News and Research

Antidepressants in pregnancy do not cause autism, study finds

CHMP recommends approval of Otsuka's Deltyba for pulmonary multidrug-resistant tuberculosis

Study shows X-ray lasers can generate complete 3-D model of protein from scratch

NEXAVAR tablets receive FDA approval for treatment of patients with thyroid cancer

New bill offers hope to HIV patients on transplant waiting lists

Sinai Hospital reports results from Phase 2a trial of apo A-I infusion therapy CSL112

New documentary reveals how antiretroviral therapy transformed lives of HIV people in Africa

Mouse study highlights importance of microorganisms in optimal cancer treatment outcomes

EYLEA Injection gets approval in Japan for treatment of macular edema following CRVO

Scientists hope to find new treatments for traumatic brain injury

Longer looks: Parents' crusade on rare diseases; fighting obesity; experts' view of alternative medicine

Targeting single enzyme in the obese could help prevent and treat diabetes

Research paves way towards personalized chronotherapy treatments

Brown fat stem cells may lead to new treatments for heart and endocrine disorders

Researchers identify a group of 39 genes linked with alcoholism

Combinatory therapy may be effective in suppressing drug resistance in treatment of melanoma

Research: New drugs show ability to rapidly shrink melanoma tumors

Antibiotic resistance holds stable in U.S. children's hospitals

Study: Patients staying on medications does not lower hospital readmission rates

Expiring patents, austerity measures lead to predictions that prescription drug sales will continue to slow

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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