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CRISPR tool unveils genetic drivers of blood cell maturation

Collaborative research led by investigators at Dana-Farber/Boston Children's Cancer and Blood Disorders Center defines a novel approach to understanding how certain proteins called transcription factors determine which genetic programs will drive cell growth and maturation.

4 Apr 2025

Study reveals the genetic arms race between X and Y sperm

In evolutionary terms, fitness is defined as an organism's ability to survive and reproduce its genes into the next generation.

4 Apr 2025

New study reveals hidden spread of C. diff in intensive care units

One of the most common health care-associated infections spreads within intensive care units (ICUs) more than three times more than previously thought, new research has found.

4 Apr 2025

Pancreatic cells show epigenetic marks before cancerous transformation

Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic "marks" in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a temporary "memory" of those cancer-linked marks.

4 Apr 2025

Innovative oral vaccine strategy combats intestinal pathogens

The issue of intestinal bacteria is a complex one. On the one hand, we are dependent on the microorganisms because they are the ones that digest the food in our intestine.

4 Apr 2025

Immigration crackdowns disrupt the caregiving industry. Families pay the price.

Alanys Ortiz reads Josephine Senek's cues before she speaks. Josephine, who lives with a rare and debilitating genetic condition, fidgets her fingers when she's tired and bites the air when something hurts.

4 Apr 2025

Study: Jumbo phages utilize EPI vesicles to evade bacterial immune response

In a growing global trend, bacteria have evolved new ways to maneuver around medical treatments for a variety of infections. The rising antibiotic resistance crisis poses a significant public health threat in hospitals and other settings, with infections resulting in millions of deaths in recent years.

4 Apr 2025

Key cellular mechanism affecting the function of mRNA vaccines revealed

A team of researchers led by Dr. Kim V. Narry, director of the Center for RNA Research at the Institute for Basic Science (IBS), has uncovered a key cellular mechanism that affects the function of mRNA vaccines and therapeutics.

3 Apr 2025

Study identifies 17 modifiable risk factors shared between stroke, dementia, and depression

Age-related brain diseases such as stroke, dementia, and late-life depression are a debilitating part of growing older, but people can lower their risk of these diseases through behavioral and lifestyle changes.

3 Apr 2025

New bacterial evolutionary map could lead to precision treatments for infections

The first-of-its-kind in-depth bacterial evolutionary map could pave the way for the development of precision treatments for certain antibiotic-resistant infections, such as urinary tract infections.

3 Apr 2025

New method traces development of nervous system and inner ear cells

Researchers at Karolinska Institutet have developed a method that shows how the nervous system and sensory organs are formed in an embryo.

3 Apr 2025

Updated screening protocols could improve early diagnosis of cystic fibrosis

All states should adopt updated screening protocols so more newborns with cystic fibrosis can be diagnosed in the first weeks of life, when interventions can have the greatest benefit, according to the Cystic Fibrosis Foundation guidelines published April 2 in the International Journal of Neonatal Screening.

3 Apr 2025

Study sheds light on how major cancer gene influences the success of PARP inhibitors

A study led by scientists at NYU Langone Health sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP inhibitors.

3 Apr 2025

Rutgers geneticists uncover fresh insights into progression of polycystic kidney disease

For patients with polycystic kidney disease (PKD), a common genetic disorder that ravages the waste-removing organ with cysts, dialysis and transplantation are among the only treatments.

3 Apr 2025

Gut bacteria may reduce the effectiveness of common medications

A new study, published today in Nature Chemistry by researchers from the University of Pittsburgh and Yale University, shows how common gut bacteria can metabolize certain oral medications that target cellular receptors called GPCRs, potentially rendering these important drugs less effective.

3 Apr 2025

New cystic fibrosis newborn screening guidelines aim for equitable detection

The United States Cystic Fibrosis Foundation released the first guideline on newborn screening for cystic fibrosis (CF), in order to improve timely detection of CF in infants from all racial and ethnic backgrounds.

3 Apr 2025

Genetic research offers hope for children with rare intestinal disorders

Further genetic testing would show that Sophie has one of a group of rare conditions called CODE (congenital diarrhea and enteropathies) that disrupts the function of cells in the intestine, causing diarrhea and preventing infants from absorbing the nutrients they need to grow and thrive.

3 Apr 2025

Exploring the relationship between testosterone and men's health

The review article titled"Testosterone and men's health: An in-depth exploration of their relationship", was published on February 18, 2025 in UroPrecision.

2 Apr 2025

Northwestern scientists develop rapid HIV test for point-of-care diagnosis

A team of Northwestern University scientists spanning disciplines have developed new technology that could lead to the creation of a rapid point-of-care test for HIV infection competitive with traditional lab-based HIV testing in a fraction of the time and without the need for a stressful wait while results are processed or confirmed in a clinical laboratory.

2 Apr 2025

Mount Sinai launches AI center to revolutionize small molecule drug discovery

The Icahn School of Medicine at Mount Sinai has launched the AI Small Molecule Drug Discovery Center, a bold endeavor that harnesses artificial intelligence (AI) to revolutionize drug development.

2 Apr 2025