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Corticosteroids may worsen disease in some patients with severe asthma

Researchers from the University of Pittsburgh Schools of the Health Sciences and UPMC have uncovered the molecular mechanism underlying corticosteroid resistance in severe asthma.

6 Jul 2017

Sialic acid found in animals protects farm children from asthma

It is a known fact that microbes on farms protect children from asthma and allergies. But even non-microbial molecules can have a protective effect: Immunologists from the University of Zurich have shown that a sialic acid found in farm animals is effective against inflammation of lung tissue.

6 Jul 2017

Anti-asthma drug shows blood glucose improvement among some patients with type 2 diabetes

After 12 weeks of taking an anti-asthma drug, a subset of patients with type 2 diabetes showed a clinically significant reduction in blood glucose during a randomized, double blind, placebo-controlled clinical trial, report University of California San Diego School of Medicine and University of Michigan researchers.

5 Jul 2017

Mitochondria-targeted antioxidant shows promise for diabetic wound treatment

Members of the Faculty of Biology and A.N. Belozersky Institute of Physico-Chemical Biology, a unit of the Lomonosov Moscow State University, have tested on a mouse model a mitochondria-targeted antioxidant, helping to treat diabetic wounds.

29 Jun 2017

New antiviral drug candidate effective against broad range of coronaviruses

A new antiviral drug candidate inhibits a broad range of coronaviruses, including the SARS and MERS coronaviruses, a multi-institutional team of investigators reports this week in Science Translational Medicine.

29 Jun 2017

Mouse brain models reveal insights into genetics of autism

While the definitive causes remain unclear, several genetic and environmental factors increase the likelihood of autism spectrum disorder, or ASD, a group of conditions covering a "spectrum" of symptoms, skills and levels of disability.

28 Jun 2017

Cancer cells may lose copies of ribosomal DNA to enable faster proliferation, study shows

Research from the Stowers Institute provides evidence suggesting that cancer cells might streamline their genomes in order to proliferate more easily.

23 Jun 2017

Extra virgin olive oil protects memory and helps prevent Alzheimer’s

In a landmark judgment, the Court of Justice of the European Union, yesterday ruled that courts could consider vaccines to be the reason for an illness despite the absence of any concrete evidence to support the connection.

21 Jun 2017

Temple researchers identify protective effects of extra-virgin olive oil against Alzheimer's disease

The Mediterranean diet, rich in plant-based foods, is associated with a variety of health benefits, including a lower incidence of dementia.

21 Jun 2017

Japanese scientists develop method to isolate anti-Alzheimer's compounds from plants

Japanese scientists have developed a method to isolate and identify active compounds in plant medicines, which accurately accounts for drug behavior in the body.

20 Jun 2017

Study finds vaccine to lower cholesterol levels could also immunize against heart disease

In people with high cholesterol levels, the fat that is built up in the artery walls narrows the arteries causing a condition called atherosclerosis. A study published on 19th June in the European Heart Journal has found the likelihood of a vaccine that can immunize humans having atherosclerosis, subsequent to successful outcomes in a mouse model study. At present, phase I clinical trial has begun in patients to see the possibility of translating the study findings to humans.

20 Jun 2017

Combination of immunotherapies effective against mouse model of rhabdomyosarcoma

Rhabdomyosarcoma, a cancer made up of cells that normally develop into skeletal muscles, is the most common soft tissue cancer in children. If it is detected early and localized in certain areas, rhabdomyosarcoma is usually curable with traditional therapies like surgery, radiation, and chemotherapy.

20 Jun 2017

Targeting regulatory T cells could be effective approach to treating cancers, research shows

Researchers at University of Pittsburgh School of Medicine and UPMC have discovered a clue that could unlock the potential of immunotherapy drugs to successfully treat more cancers.

15 Jun 2017

Blocking newly discovered cellular pathway could help control tumor growth

Scientists have discovered a new cellular pathway that can promote and support the growth of cancer cells. In a mouse model of melanoma, blocking this pathway resulted in reduction of tumor growth.

15 Jun 2017

Scientists show how brain circuits govern hunger and cravings

The urge to satisfy hunger is a primal one, but – as any dieter knows – choices about when and what to eat can be influenced by cues in the environment, not just how long it's been since breakfast.

14 Jun 2017

New research could help mitigate effects of radiation therapy

New research conducted at the University of Kansas Medical Center could make treatment for gastrointestinal cancers safer- while also helping to mitigate the dangers of nuclear accidents and terrorist attacks.

14 Jun 2017

Scientists uncover mechanism that directly links inflammation to mental illness

Up to 75 percent of patients with systemic lupus erythematosus -- an incurable autoimmune disease commonly known as lupus -- experience neuropsychiatric symptoms.

14 Jun 2017

Researchers use quantum dots to decipher design features for new therapies aimed at MS

Researchers in the University of Maryland Fischell Department of Bioengineering (BIOE) Jewell Laboratory are using quantum dots - tiny semiconductor particles commonly used in nanotechnology - to decipher the features needed to design specific and effective therapies for multiple sclerosis (MS) and other autoimmune diseases.

14 Jun 2017

Pyk2 deficits contribute to memory problems in Huntington’s disease mouse model

Researchers from the Institute of Neurosciences of the UB and from IDIBAPS together with a team from the University Pierre and Marie Curie and the Institute du Fer à Moulin, published a study in Nature Communications, which demonstrates that the regulation in Pyk2, a protein-tyrosine kinase, causes alterations of the synaptic plasticity involved in memory tasks, associated with the hippocampus in mouse models of neurodegenerative diseases, such as Huntington's.

13 Jun 2017

New molecular compound improves balance and coordination in mouse model of Parkinson's disease

Researchers at UCLA have developed a molecular compound that improves balance and coordination in mice with early stage Parkinson's disease.

13 Jun 2017

Mouse Model News and Research

Corticosteroids may worsen disease in some patients with severe asthma

Sialic acid found in animals protects farm children from asthma

Anti-asthma drug shows blood glucose improvement among some patients with type 2 diabetes

Mitochondria-targeted antioxidant shows promise for diabetic wound treatment

New antiviral drug candidate effective against broad range of coronaviruses

Mouse brain models reveal insights into genetics of autism

Cancer cells may lose copies of ribosomal DNA to enable faster proliferation, study shows

Extra virgin olive oil protects memory and helps prevent Alzheimer’s

Temple researchers identify protective effects of extra-virgin olive oil against Alzheimer's disease

Japanese scientists develop method to isolate anti-Alzheimer's compounds from plants

Study finds vaccine to lower cholesterol levels could also immunize against heart disease

Combination of immunotherapies effective against mouse model of rhabdomyosarcoma

Targeting regulatory T cells could be effective approach to treating cancers, research shows

Blocking newly discovered cellular pathway could help control tumor growth

Scientists show how brain circuits govern hunger and cravings

New research could help mitigate effects of radiation therapy

Scientists uncover mechanism that directly links inflammation to mental illness

Researchers use quantum dots to decipher design features for new therapies aimed at MS

Pyk2 deficits contribute to memory problems in Huntington’s disease mouse model

New molecular compound improves balance and coordination in mouse model of Parkinson's disease

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