Mouse Model News and Research

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Tumor microenvironment poses unique challenges for effective ovarian cancer T-cell therapy

Fred Hutchinson Cancer Research Center immunotherapy researchers Drs. Kristin Anderson and Philip Greenberg and their colleagues are working on ways to tweak their team's early successes with T-cell therapy for leukemia to apply to solid tumors.

5 Apr 2017

Researchers find link between hormones and inguinal hernias in older men

Researchers have identified an apparent cause of inguinal hernia, or groin hernia, in older men: altered sex hormone levels that weaken and scar muscle tissue in the lower abdomen.

3 Apr 2017

Researchers use mathematical modeling to raise density of bones badly degraded by osteoporosis

They may seem rigid and set in their ways, but your bones are actually under constant construction and deconstruction. They give up their nutrient treasures (calcium) to the body and then rebuild in a constant give-and-take sort of rhythm.

29 Mar 2017

Scientists develop humanized mouse model for analyzing functions of NK cells in vivo

Researchers affiliated with the Kawasaki INnovation Gateway at SKYFRONT, have successfully developed a humanized mouse model showing that so-called NK cells that directly attacking tumors, can survive and maintain function in vivo.

28 Mar 2017

Study shows decreasing telomere length may contribute to onset of age-related diseases

Mouse models of human disease have made it possible to gain important insights into many conditions. However, many diseases remain for which no mouse model exists, and large proportion of human diseases without mouse models are associated with aging.

28 Mar 2017

Stem cell therapy can reduce lung inflammation in mouse model of COPD and cystic fibrosis

A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Although, still at a pre-clinical stage, these findings have important potential implications for the future treatment of patients.

25 Mar 2017

First-of-its-kind mouse model could help study post-malaria epilepsy in children

A first-of-its-kind mouse model could lead to an understanding of how cerebral malaria infection leads to the development of epilepsy in children, and to the prevention of seizures.

23 Mar 2017

Inner ear gene therapy holds promise for treating patients with hearing loss and dizziness

In a first-of-its-kind study published in the March 1, 2017 edition of Molecular Therapy, researchers from the National Institute on Deafness and Other Communication Disorders and Johns Hopkins University School of Medicine showed that gene therapy was able to restore balance and hearing in genetically modified mice that mimic Usher Syndrome, a genetic condition in humans characterized by partial or total hearing loss, dizziness, and vision loss that worsens over time.

23 Mar 2017

Intratumoral vaccination prolongs survival in mouse model of early stage resected pancreatic cancer

Building on their previous research focusing on vaccination within a tumor (intratumoral) for the most common form of pancreatic cancer, investigators from Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School have shown that in a mouse model of early stage resected pancreatic cancer, intratumoral vaccination induces an anti-tumor response that results in a significant improvement in overall survival.

23 Mar 2017

Researchers uncover gene mutation that may provide answers to unexplained female infertility

Researchers at Baylor College of Medicine, Texas Children's Hospital and Rice University have uncovered a gene mutation that may provide answers to unexplained female infertility. The study appears in Scientific Reports, a member of the Nature family of journals.

22 Mar 2017

Tulane researcher aims to improve hormone replacement therapy for post-menopausal women

New research at the Tulane School of Medicine is looking at an estrogen receptor that could be a site for targeted hormone replacement therapy in post-menopausal women.

16 Mar 2017

Study provides insights into genetic, neuronal circuit mechanisms linked to autism's impaired sociability

Researchers at Beth Israel Deaconess Medical Center have gained new insight into the genetic and neuronal circuit mechanisms that may contribute to impaired sociability in some forms of Autism Spectrum Disorder.

16 Mar 2017

UB research yields neural crest cells from adult skin cells without genetic modification

A discovery, several years in the making, by a University at Buffalo research team has proven that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic modification, and that these stem cells can yield other cells that are present in the spinal cord and the brain.

15 Mar 2017

Researchers make surprising and crucial discovery about Alexander disease

Researchers at the University of Wisconsin-Madison have made a surprising and potentially crucial discovery about Alexander disease, a rare and fatal neurological disorder with no known cure.

15 Mar 2017

Research shows pNaKtide can attenuate development of NAFLD and atherosclerosis

Building on their recent research focusing on a peptide, pNaKtide, designed to block the oxidant amplifying function of the cellular sodium-potassium pump, researchers at Marshall University Joan C. Edwards School of Medicine have successfully demonstrated that pNaKtide, can attenuate the development of experimental nonalcoholic fatty liver disease (NAFLD) and atherosclerosis.

15 Mar 2017

Targeting cancer stem cells may be effective way to prevent spread of squamous cell carcinoma

Targeting cancer stem cells may be a more effective way to overcome cancer resistance and prevent the spread of squamous cell carcinoma — the most common head and neck cancer and the second-most common skin cancer, according to a new study by cancer researchers at the UCLA School of Dentistry.

10 Mar 2017

Combination therapy that targets immune-busting cells effective in treating advanced prostate cancer

Advanced prostate cancer resistant to castration therapy appears to respond well to a combination of immune checkpoint blockades and treatments that target certain immune-busting cells commonly associated with poor patient prognosis and therapy resistance.

10 Mar 2017

Drug could activate innate anti-tumor immunity to eradicate aggressive prostate cancer in mice

Cabozantinib, a drug already used to treat patients with certain types of thyroid or kidney cancer, was able to eradicate invasive prostate cancers in mice by causing tumor cells to secrete factors that entice neutrophils - the first-responders of the immune system - to infiltrate the tumor, where they triggered an immune response that led to tumor clearance.

9 Mar 2017

Study reveals promising new strategy to attack deadly pediatric brain tumor

Researchers from Northwestern Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago have revealed new insight into how the most deadly pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG), may develop.

7 Mar 2017

TSRI scientists discover how key protein establishes proper vision

Scientists from the Florida campus of The Scripps Research Institute have discovered how a protein called α2δ4 establishes proper vision.

6 Mar 2017

Mouse Model News and Research

Tumor microenvironment poses unique challenges for effective ovarian cancer T-cell therapy

Researchers find link between hormones and inguinal hernias in older men

Researchers use mathematical modeling to raise density of bones badly degraded by osteoporosis

Scientists develop humanized mouse model for analyzing functions of NK cells in vivo

Study shows decreasing telomere length may contribute to onset of age-related diseases

Stem cell therapy can reduce lung inflammation in mouse model of COPD and cystic fibrosis

First-of-its-kind mouse model could help study post-malaria epilepsy in children

Inner ear gene therapy holds promise for treating patients with hearing loss and dizziness

Intratumoral vaccination prolongs survival in mouse model of early stage resected pancreatic cancer

Researchers uncover gene mutation that may provide answers to unexplained female infertility

Tulane researcher aims to improve hormone replacement therapy for post-menopausal women

Study provides insights into genetic, neuronal circuit mechanisms linked to autism's impaired sociability

UB research yields neural crest cells from adult skin cells without genetic modification

Researchers make surprising and crucial discovery about Alexander disease

Research shows pNaKtide can attenuate development of NAFLD and atherosclerosis

Targeting cancer stem cells may be effective way to prevent spread of squamous cell carcinoma

Combination therapy that targets immune-busting cells effective in treating advanced prostate cancer

Drug could activate innate anti-tumor immunity to eradicate aggressive prostate cancer in mice

Study reveals promising new strategy to attack deadly pediatric brain tumor

TSRI scientists discover how key protein establishes proper vision

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