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Neurons involved in creating negative emotional states and chronic stress identified

Researchers at Karolinska Institutet in Sweden have identified a group of nerve cells in the mouse brain that are involved in creating negative emotional states and chronic stress. The

22 Jun 2023

The link between Covid-19 and Alzheimer's disease established

Renin-angiotensin system, or RAS, is a physiological mechanism essential to human body function. The SARS-CoV-2 virus causes overactivation and malfunction of this system.

21 Jun 2023

New insights into lymphatic cell migration and lymphatic vessel remodeling

Lymphangiogenesis refers to the formation and remodeling of lymphatic vessels (a network of thin tubes that carry lymph in the lymphatic system), and it supports the transport of molecules and immune cells around the body.

21 Jun 2023

Uncovering the hidden genetic connections behind COVID-19 and comorbidities

Researchers performed a protein diffusion network analysis using tissue-specific GRNs to identify predispositions to COVID-19.

21 Jun 2023

Treatment with dupilumab leads to sustained improvements in COPD patients with type 2 inflammation

Chronic obstructive pulmonary disease patients with type 2 inflammation saw rapid and sustained improvements in their disease after treatment with the monoclonal antibody dupilumab, according to a yearlong, Phase 3 clinical trial reported in the New England Journal of Medicine.

20 Jun 2023

New treatment could be instrumental in restoring the blood-brain barrier's normal function

There's a bouncer in everyone: The blood-brain barrier, a layer of cells between blood vessels and the rest of the brain, kicks out toxins, pathogens and other undesirables that can sabotage the brain's precious gray matter.

20 Jun 2023

Study highlights the role of high cholesterol in SARS-CoV-2 infectivity

A recent study unveiled the doorway that SARS-CoV2 uses to slip inside cells undetected.

20 Jun 2023

Intranasal delivery of CRISPR/Cas9 therapeutics may help treat chronic anxiety

A study in mice reports a CRISPR/Cas9 gene-editing delivery system, capable of bypassing the blood-brain-barrier and modulating neuronal receptor pathways, to treat chronic anxiety.

20 Jun 2023

Phase I clinical study of TCR NK cell therapy for sarcoma expected to commence later this year

The University of Texas MD Anderson Cancer Center and Replay today announced that the Food & Drug Administration (FDA) has issued a 'safe to proceed' for the Investigational New Drug (IND) application for NY-ESO-1 TCR/IL-15 NK, an engineered T cell receptor natural killer (TCR NK) cell therapy for advanced synovial sarcoma and myxoid/round cell liposarcoma.

20 Jun 2023

Alcohol-induced psychomotor performance impairment in young adult drinkers with alcohol usage disorders

Researchers examined alcohol-induced psychomotor performance impairments among young adult alcohol consumers with alcohol usage disorders (AUDs).

20 Jun 2023

Urban jungle: How city living may impact mental health

Researchers explore the effects of the urban environment on adult mental health.

19 Jun 2023

Unlocking HIV cure: Study highlights allogeneic immunity as key mechanism in eradicating latent virus reservoirs

Allogeneic stem cell transplantation with CCR5Δ32/Δ32 donors shows potential for HIV cure. Alloimmunity and CCR5 deficiency play significant roles in viral reservoir clearance.

19 Jun 2023

Researchers create a detailed map of neurotransmitter receptors that control information flow

Receptor patterns define key organizational principles in the brain, scientists have discovered.

19 Jun 2023

New mapping by Human Brain Project advances the understanding of neuroreceptor organization

A key challenge in neuroscience is to understand how the brain can adapt to a changing world, even with a relatively static anatomy.

19 Jun 2023

Comparing the cost-effectiveness of SGLT2i versus mineralocorticoid antagonists

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are approved for heart failure with reduced ejection fraction (HFrEF).

19 Jun 2023

Combination of two drugs may be more effective in treating resistant breast cancer

Cancer cells are even smarter than scientists previously believed, according to new CU Boulder research.

16 Jun 2023

Developing novel statistical approaches to better predict breast cancer progression and survival

Breast cancer is a complex disease, and its progression is difficult, yet important, to predict.

16 Jun 2023

Researchers review the principles of universal vaccine development for key pandemic potential viruses

A recent review addressed the efforts to develop universal vaccines for viruses at family and genus levels.

16 Jun 2023

New research finds most women diagnosed with early breast cancer can expect to become long-term survivors

Researchers reported longitudinal outcomes among British women suffering from early invasive-type breast tumors as their initial tumor and those initially treated by surgical methods such as conservative surgery or mastectomy.

16 Jun 2023

Research explores complex relationship between cholesterol and breast cancer risk

Research explores the complex relationship between cholesterol and breast cancer risk, with some studies suggesting an increased risk with elevated cholesterol levels while others find an inverse association.

15 Jun 2023

Receptor News and Research

Neurons involved in creating negative emotional states and chronic stress identified

The link between Covid-19 and Alzheimer's disease established

New insights into lymphatic cell migration and lymphatic vessel remodeling

Uncovering the hidden genetic connections behind COVID-19 and comorbidities

Treatment with dupilumab leads to sustained improvements in COPD patients with type 2 inflammation

New treatment could be instrumental in restoring the blood-brain barrier's normal function

Study highlights the role of high cholesterol in SARS-CoV-2 infectivity

Intranasal delivery of CRISPR/Cas9 therapeutics may help treat chronic anxiety

Phase I clinical study of TCR NK cell therapy for sarcoma expected to commence later this year

Alcohol-induced psychomotor performance impairment in young adult drinkers with alcohol usage disorders

Urban jungle: How city living may impact mental health

Unlocking HIV cure: Study highlights allogeneic immunity as key mechanism in eradicating latent virus reservoirs

Researchers create a detailed map of neurotransmitter receptors that control information flow

New mapping by Human Brain Project advances the understanding of neuroreceptor organization

Comparing the cost-effectiveness of SGLT2i versus mineralocorticoid antagonists

Combination of two drugs may be more effective in treating resistant breast cancer

Developing novel statistical approaches to better predict breast cancer progression and survival

Researchers review the principles of universal vaccine development for key pandemic potential viruses

New research finds most women diagnosed with early breast cancer can expect to become long-term survivors

Research explores complex relationship between cholesterol and breast cancer risk

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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