in vitro News and Research

RSS

Zinc supplementation bolsters repurposed antivirals against SARS-CoV-2

A new preprint reports the efficacy of two repurposed drugs that could be useful against SARS-CoV-2 when supplemented with zinc.

2 Feb 2021

Antiviral compound GC-376 shows efficacy against SARS-CoV-2 in vivo

Over the past months, many potential antivirals against SARS-CoV-2 have been identified as deserving further development to target several viral proteins. A new study deals with one such molecule, the viral main protease (Mpro) inhibitor GC-376, and describes its efficacy in inhibiting virus-host interaction.

2 Feb 2021

Elevated ACE2 and inflammation levels increase risk for pregnant women infected with SARS-CoV-2

Among the hundred million or so cases of coronavirus disease 2019 (COVID-19) that have occurred since the pandemic began, pregnant women have been a conspicuous risk group. However, the exact nature of the risk they and their fetuses face, and the mechanism by which it operates, is far from clear.

2 Feb 2021

Synthetic biology can help create complex embryo

Richard Feynman, one of the most respected physicists of the twentieth century, said "What I cannot create, I do not understand". Not surprisingly, many physicists and mathematicians have observed fundamental biological processes with the aim of precisely identifying the minimum ingredients that could generate them. One such example are the patterns of nature observed by Alan Turing.

2 Feb 2021

Increased access to testing, treatment has reduced hepatitis C in low- and middle-income countries

Many low- and middle-income countries have reduced suffering from hepatitis C, thanks to increased access to testing and treatment.

1 Feb 2021

New WHO essential diagnostics list expands the suite of tests to promote better health

To address the lack of access to tests and testing services in multiple countries, WHO since 2018 has published a yearly essential diagnostics list (EDL), a basket of recommended in vitro diagnostics that should be available at point-of-care and in laboratories in all countries to increase timely and life-saving diagnoses.

1 Feb 2021

New COVID-19 variant identified in Brazilian Amazon spreads faster

A new variant of the virus that causes COVID-19, identified in Brazil, is likely more transmissible than its parent strain because of mutations in the spike protein, according to researchers.

1 Feb 2021

Can metformin reduce mortality in diabetic individuals with severe COVID-19?

A new study by researchers in China and the U.S. describes a round-up of the effects of commonly used hypoglycemic drugs on the outcomes of COVID-19 in diabetic patients.

1 Feb 2021

Ivermectin may not be the ‘silver bullet’ antiviral against COVID-19

A team of researchers based in Peru and the U.S. recently examined the role of the anti-parasitic drug ivermectin in treating COVID-19.

1 Feb 2021

Synergistic effect between NF-κB inhibitors and zinc in vitro reducing ACE2 expression

Researchers at National Taiwan University Hospital in Taipei have conducted a study demonstrating the potential effectiveness of a novel drug combination at reducing morbidity and mortality in coronavirus disease 2019 (COVID-19).

31 Jan 2021

DSMB recommends continuation of Phase 2/3 study of opaganib for severe COVID-19

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced that the independent Data Safety Monitoring Board (DSMB) for the global Phase 2/3 study of opaganib in patients with severe COVID-19, unanimously recommended to continue the study following a pre-scheduled futility review of unblinded efficacy data from the first 135 patients treated in the study and safety data from the first 175 patients.

30 Jan 2021

Discovery offers novel possibilities to target drug-resistant HER2-positive cancers

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells.

29 Jan 2021

SORLA protein promotes the growth of breast cancer brain metastasis

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells.

29 Jan 2021

3D-printable resins used in dental applications may be toxic to reproductive health

3D-printable resins, such as those used in dental applications, are marketed as biocompatible. Clear tooth aligners, a multi-billion-dollar industry, use these resins. Many other consumer products use 3D-printable resins.

28 Jan 2021

What do we know about the SARS-CoV-2 vaccines so far?

A new study surveys what we know so far about SARS-CoV-2 vaccine candidates from advanced clinical trials.

27 Jan 2021

Allarity Therapeutics announces plans to test antiviral activity of stenoparib drug

Allarity Therapeutics of Hørsholm, Denmark, today announced plans to further test the antiviral activity of stenoparib, its PARP inhibitor, against SARS-CoV-2 lineage B.1.1.7, also known as Coronavirus Variant B117 (the "British variant"), at the COVID-19 Testing Service Center (CTSC) of Northern Arizona University's Pathogen and Microbiome Institute (PMI), a leading U.S. infectious disease testing center.

27 Jan 2021

New contraceptive gel contains spermicidal, anti-viral, libido-enhancing agents in one formulation

Researchers from North Carolina State University have created a trifunctional contraceptive gel that contains spermicidal, anti-viral and libido-enhancing agents in one formulation.

27 Jan 2021

New data shows that mINDY gene is involved in blood pressure regulation

Authors from the German Center for Diabetes Research (DZD) presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation in the Journal of Clinical Investigation (JCI) insight.

27 Jan 2021

Iron-carrying extracellular vesicles promote viral-bacterial co-infection

The mechanism by which acute viral respiratory infections promote secondary bacterial growth and infection in the airways depends on iron-carrying extracellular sacs secreted by the cells lining the host's airways, report researchers from the University of Pittsburgh School of Medicine in a paper published today in Cell Reports.

26 Jan 2021

Sodium fluorescein may improve the safety and outcomes of vestibular schwannoma surgery

Removing a vestibular schwannoma - a slow-growing, benign tumor that develops in the nerves connecting the inner ear to the brain - is a delicate procedure. Surgeons must differentiate the tumor from nearby nerves, arteries, and other intracranial structures.

26 Jan 2021

in vitro News and Research

Zinc supplementation bolsters repurposed antivirals against SARS-CoV-2

Antiviral compound GC-376 shows efficacy against SARS-CoV-2 in vivo

Elevated ACE2 and inflammation levels increase risk for pregnant women infected with SARS-CoV-2

Synthetic biology can help create complex embryo

Increased access to testing, treatment has reduced hepatitis C in low- and middle-income countries

New WHO essential diagnostics list expands the suite of tests to promote better health

New COVID-19 variant identified in Brazilian Amazon spreads faster

Can metformin reduce mortality in diabetic individuals with severe COVID-19?

Ivermectin may not be the ‘silver bullet’ antiviral against COVID-19

Synergistic effect between NF-κB inhibitors and zinc in vitro reducing ACE2 expression

DSMB recommends continuation of Phase 2/3 study of opaganib for severe COVID-19

Discovery offers novel possibilities to target drug-resistant HER2-positive cancers

SORLA protein promotes the growth of breast cancer brain metastasis

3D-printable resins used in dental applications may be toxic to reproductive health

What do we know about the SARS-CoV-2 vaccines so far?

Allarity Therapeutics announces plans to test antiviral activity of stenoparib drug

New contraceptive gel contains spermicidal, anti-viral, libido-enhancing agents in one formulation

New data shows that mINDY gene is involved in blood pressure regulation

Iron-carrying extracellular vesicles promote viral-bacterial co-infection

Sodium fluorescein may improve the safety and outcomes of vestibular schwannoma surgery

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Latest News