Cell Biology News and Research

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Muscle, aptly enough, is born of cellular bullying, and not mutual consent

In fact, according to new research from Johns Hopkins, the fusion of muscle cells is a power struggle that involves a smaller mobile antagonist that points at, pokes and finally pushes into its larger, stationary partner using a newly identified finger-like projection.

17 Feb 2011

Study: Overexpression of EZH2 protein promotes breast cancer progression

An essential protein for normal stem cell renewal also promotes the growth of breast cancer stem cells when it's overproduced in those cells, researchers at The University of Texas MD Anderson Cancer Center report in the February edition of Cancer Cell.

16 Feb 2011

New research finds differences in cell fate commitment during embryonic development in mammals

New research shows that all not mammals are created equal. In fact, this work shows that the animals most commonly used by scientists to study mammalian genetics -- mice -- develop unusually quickly and may not always be representative of embryonic development in other mammals.

15 Feb 2011

Study shows beneficial anti-fibrotic effects of Pentraxin-2 in idiopathic pulmonary fibrosis

Promedior, Inc., a clinical stage biotechnology company developing novel therapies to treat fibrotic and inflammatory diseases, announced today the publication of collaborative research in the International Journal of Biochemistry and Cell Biology entitled, "TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P."

14 Feb 2011

Spinal cord sugar residues regulate growth and survival of nerve cells: Study

Researchers in Bochum have found out that certain sugar residues in the spinal cord regulate the growth and survival of nerve cells which control the movement of muscles. "We hope that our findings can improve regenerative treatment of nerve injuries", explains Prof. Dr. Stefan Wiese from the Molecular Cell Biology study group.

14 Feb 2011

Study reveals beneficial anti-fibrotic effects of Pentraxin-2 in TGFβ1-induced lung disease

11 Feb 2011

Single molecule imaging movies of living cell membranes clarify enigma surrounding receptor molecule behaviors

Unprecedented single molecule imaging movies of living cell membranes, taken by a research team based at Kyoto University and the University of New Mexico, have clarified a decades-old enigma surrounding receptor molecule behaviors. The results, appearing in the latest issue of the Journal of Cell Biology, promise to open the door to new possibilities for drug development.

9 Feb 2011

TREK1 activity offers a key target for fluoxetine and other antidepressant drugs

Using a unique and relatively simple cell-based fluorescent assay they developed, scientists with the U.S. Department of Energy's Lawrence Berkeley National Laboratory and the University of California, Berkeley have identified a means by which fluoxetine, the active ingredient in Prozac, suppresses the activity of the TREK1 potassium channel.

8 Feb 2011

Research unmasks long sought stem cell origin of carcinoma

A constellation of different stem cell populations within our skin help it to cope with normal wear and tear. By constantly proliferating, the stem cells allow skin to replenish itself, allowing each cell to be replaced by a new one about once a month. But the normal cycle of division and death within one or more of these stem cell types can sometimes be derailed by genetic mishaps. Such events are believed to spawn carcinomas and other deadly skin cancers, which are the mostly frequently diagnosed cancers in the United States.

4 Feb 2011

Generation of iPSCs can be enhanced by modulating miRNA action

Stem cells are ideal tools to understand disease and develop new treatments; however, they can be difficult to obtain in necessary quantities. In particular, generating induced pluripotent stem (iPS) cells can be an arduous task because reprogramming differentiated adult skin cells into iPS cells requires many steps and the efficiency is very low - researchers might end up with only a few iPS cells even if they started with a million skin cells.

3 Feb 2011

Researchers grow arteries with elasticity of natural blood vessels outside the body

University of Pittsburgh researchers have grown arteries that exhibit the elasticity of natural blood vessels at the highest levels reported, a development that could overcome a major barrier to creating living-tissue replacements for damaged arteries, the team reports in the Proceedings of the National Academy of Sciences.

1 Feb 2011

Scientists create 'reporter mouse' to close gap between kidney injury and diagnosis

The current check for kidney disease is a simple blood test for serum creatinine, but it can take longer than two days for this metabolite to accumulate to levels that are significant enough to indicate kidney damage - and by then it may be too late to intervene.

1 Feb 2011

Scientists convert adult skin cells into cardiomyocytes using direct reprogramming strategy

Scripps Research Institute scientists have converted adult skin cells directly into beating heart cells efficiently without having to first go through the laborious process of generating embryonic-like stem cells. The powerful general technology platform could lead to new treatments for a range of diseases and injuries involving cell loss or damage, such as heart disease, Parkinson's, and Alzheimer's disease.

30 Jan 2011

UMMS, Lundbeck announce research collaboration to develop targeted therapy for HD

The University of Massachusetts Medical School and Lundbeck Inc. today announced a research collaboration aimed at further development of a targeted therapy to slow or halt the progression of Huntington's disease.

29 Jan 2011

Both absence of insulin and resistance to insulin are associated with defects in FAS

A key mechanism that appears to contribute to blood vessel damage in people with diabetes has been identified by researchers at Washington University School of Medicine in St. Louis.

28 Jan 2011

Phase II trial finds fostamatinib ineffective in RA patients not responsive to biologic agents

In a previous study, rheumatoid arthritis (RA) patients who failed to respond to methotrexate were shown to experience positive results with fostamatinib disodium (R788), an oral spleen tyrosine kinase (Syk) inhibitor that is thought to block immune cell signaling involved with bone and cartilage destruction. In the current study, RA patients who failed to respond to biologic agents were studied.

28 Jan 2011

UMMS, Lundbeck enter research collaboration to develop targeted therapy for HD

The University of Massachusetts Medical School and Lundbeck today announced a research collaboration aimed at further development of a targeted therapy to slow or halt the progression of Huntington's disease.

28 Jan 2011

Bax factor that promotes cell death is also involved in regulating mitochondria behavior

New research led by UC Davis scientists provides insight into why some body organs are more susceptible to cell death than others and could eventually lead to advances in treating or preventing heart attack or stroke.

24 Jan 2011

Functional tests are necessary to understand human disease despite genetic sequencing

Despite what you might have heard, genetic sequencing alone is not enough to understand human disease. Researchers at Duke University Medical Center have shown that functional tests are absolutely necessary to understand the biological relevance of the results of sequencing studies as they relate to disease, using a suite of diseases known as the ciliopathies which can cause patients to have many different traits.

24 Jan 2011

Cancer Research UK launches new Centre in Glasgow

Cancer Research UK today (Thursday) launches a new Centre which will accelerate the pace of research in Glasgow and see the city become a world leader in the development of new treatments tailored for individual cancer patients.

21 Jan 2011

Cell Biology News and Research

Muscle, aptly enough, is born of cellular bullying, and not mutual consent

Study: Overexpression of EZH2 protein promotes breast cancer progression

New research finds differences in cell fate commitment during embryonic development in mammals

Study shows beneficial anti-fibrotic effects of Pentraxin-2 in idiopathic pulmonary fibrosis

Spinal cord sugar residues regulate growth and survival of nerve cells: Study

Study reveals beneficial anti-fibrotic effects of Pentraxin-2 in TGFβ1-induced lung disease

Single molecule imaging movies of living cell membranes clarify enigma surrounding receptor molecule behaviors

TREK1 activity offers a key target for fluoxetine and other antidepressant drugs

Research unmasks long sought stem cell origin of carcinoma

Generation of iPSCs can be enhanced by modulating miRNA action

Researchers grow arteries with elasticity of natural blood vessels outside the body

Scientists create 'reporter mouse' to close gap between kidney injury and diagnosis

Scientists convert adult skin cells into cardiomyocytes using direct reprogramming strategy

UMMS, Lundbeck announce research collaboration to develop targeted therapy for HD

Both absence of insulin and resistance to insulin are associated with defects in FAS

Phase II trial finds fostamatinib ineffective in RA patients not responsive to biologic agents

UMMS, Lundbeck enter research collaboration to develop targeted therapy for HD

Bax factor that promotes cell death is also involved in regulating mitochondria behavior

Functional tests are necessary to understand human disease despite genetic sequencing

Cancer Research UK launches new Centre in Glasgow

Cell Density eBook - What are the Many Applications of Cell Density Sensors? eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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