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Scientists identify new drugs that have potential to slow down progression of Parkinson's

New drugs which may have the potential to stop faulty brain cells dying and slow down the progression of Parkinson's, have been identified by scientists in a pioneering study which is the first of its kind.

4 Sep 2013

UCLA researchers receives $13M Early Translational grants to advance innovative discoveries using stem cells

Four researchers from UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have received Early Translational Research Awards totaling approximately $13 million from the California Institute for Regenerative Medicine, the state's stem cell agency. The UCLA researchers received four of the 12 total awards; no other institution received more than one.

4 Sep 2013

Researchers identify role played by protein in controlling brain activity during seizure

People with epilepsy could be helped by new research into the way a key molecule controls brain activity during a seizure. Researchers have identified the role played by of a protein - called BDNF - and say the discovery could lead to new drugs that calm the symptoms of epileptic seizures.

4 Sep 2013

AQUARIUS trial data shows Aliskiren reduced incidents of death, stroke, heart attack

Patients with clogged and hardened arteries who already have their blood pressure under control may benefit from an additional blood pressure-lowering medication, according to research from the Cleveland Clinic Coordinating Center for Clinical Research (C5Research).

4 Sep 2013

Chronic granulomatous disease (CGD) research: an interview with Dr. Griffin Rodgers, NIDDK director

Chronic granulomatous disease, or CGD, is a diverse group of inherited diseases in which certain cells of the immune system have difficulty forming reactive oxygen compounds, most importantly superoxide radicals. These are used by these white blood cells to kill certain bacteria.

3 Sep 2013

Acacia Pharma raises $23.5 million in Series B financing

Acacia Pharma, a pharmaceutical company specialising in the development of drugs for supportive care, announces it has raised £15 million (~$23.5 million) in a Series B financing led by Fidelity Biosciences and Novo A/S.

3 Sep 2013

Authors of new paper outline possible factors to identify metabolically healthy obesity

Metabolically healthy obesity – where an individual has a Body Mass Index of greater than 30 but does not appear to be at increased risk of the health complications usually associated with excess weight – has only been recently widely recognised by medical practitioners.

3 Sep 2013

Argininosuccinic aciduria (ASA) and gene therapy: an interview with Dr Julien Baruteau, UCL Institute for Women's Health, London

This rare genetic condition can theoretically affect patients at any age but symptoms are more often observed in childhood and even uncommonly during the first days of life.

2 Sep 2013

Researchers identify origin of human TB

Tuberculosis remains one of deadliest infectious diseases of humans, killing 50% of individuals when left untreated. Even today, TB causes 1-2 million deaths every year mainly in developing countries. Multidrug-resistance is a growing threat in the fight against the disease.

2 Sep 2013

Researchers develop new model to predict treatment success more accurately

The HI virus is feared, not least, because of its great adaptability. If the virus mutates at precisely the point targeted by a drug, it is able to neutralise the attack and the treatment fails. To minimise these viral defence mechanisms, doctors treat patients with modern combination therapies involving the simultaneous administration of several drugs. This approach forces the virus to run through a series of mutations before it becomes immune to the drugs.

2 Sep 2013

Anti-diabetic drug alogliptin meets primary endpoint in EXAMINE trial

Patients with type 2 diabetes and high cardiovascular risk due to recent acute coronary syndromes had similar rates of cardiovascular events when treated with the anti-diabetic agent alogliptin compared to placebo according to results of the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care trial presented at the European Society of Cardiology Congress.

2 Sep 2013

Debiopharm starts Debio 1347 phase I study in patients with advanced solid tumors

Debiopharm Group, the Swiss-based global biopharmaceutical company that focuses on the development of prescription drugs that target unmet medical needs including oncology, today announced the start of a phase I, open label multicenter study of a selective FGFR 1, 2, 3 inhibitor, Debio 1347 (CH5183284) in patients with advanced solid tumors.

2 Sep 2013

Pre-treatment with prasugrel increases risk of bleeding without reducing risk of ischemic events

In patients with non-ST-elevation acute coronary syndrome (NSTE- ACS), pre-treatment with the P2Y12 antagonist prasugrel prior to catheterization, significantly increases the risk of life-threatening bleeding without reducing the risk of major ischemic events, according to the results of the ACCOAST (A Comparison of Prasugrel at PCI or Time of Diagnosis of Non-ST Elevation Myocardial Infarction) trial.

2 Sep 2013

Reimbursement systems appear to impact on achievement of cholesterol lowering targets

Dr Gitt said: "There are wide variations between European countries in the achievement of LDL-cholesterol (LDL-C) targets. However the effect of different reimbursement systems on meeting the targets was unknown."

2 Sep 2013

Researchers pinpoint ways to counter effects of antibiotics-driven depletion of gut-dwelling bacteria

A new study by researchers at the Stanford University School of Medicine could help pinpoint ways to counter the effects of the antibiotics-driven depletion of friendly, gut-dwelling bacteria.

2 Sep 2013

Holistic approach to understand and treat TB

For years, physicians around the world have watched as strain after strain of the deadly bacteria Mycobacterium tuberculosis evolves resistance to drugs.

2 Sep 2013

Nanostructures made of DNA strands can encapsulate, release small-molecule drugs

Nanoscale "cages" made from strands of DNA can encapsulate small-molecule drugs and release them in response to a specific stimulus, McGill University researchers report in a new study.

2 Sep 2013

Viewpoints: Tying 'social safeguards' to work may not be best policy; GOP missing an opportunity by not offering alternative to health law; food makers' health claims 'hard to swallow'

In May, the head of [Trader Joe's] ... sent a confidential memo to employees notifying them of changes to their health coverage, retirement program and wages. ... He pledged to reduce workers' healthcare costs 10% for the remainder of the year while the company determines its response to changes under the Affordable Care Act. ...

31 Aug 2013

Small chemical changes to dietary flavonoids cause large effects on human immune system

Scientists at the University of York have discovered that very small chemical changes to dietary flavonoids cause very large effects when the plant natural products are tested for their impact on the human immune system.

31 Aug 2013

Researchers identify potential drug target to recover from jet lag, disruptions in circadian system

University of Notre Dame researchers, as part of a collaborative effort, have identified a protein that potentially could be a target for drugs that would help people recover faster from jet lag and better adjust their circadian rhythms during rotational shift work.

31 Aug 2013

Drugs News and Research

Scientists identify new drugs that have potential to slow down progression of Parkinson's

UCLA researchers receives $13M Early Translational grants to advance innovative discoveries using stem cells

Researchers identify role played by protein in controlling brain activity during seizure

AQUARIUS trial data shows Aliskiren reduced incidents of death, stroke, heart attack

Chronic granulomatous disease (CGD) research: an interview with Dr. Griffin Rodgers, NIDDK director

Acacia Pharma raises $23.5 million in Series B financing

Authors of new paper outline possible factors to identify metabolically healthy obesity

Argininosuccinic aciduria (ASA) and gene therapy: an interview with Dr Julien Baruteau, UCL Institute for Women's Health, London

Researchers identify origin of human TB

Researchers develop new model to predict treatment success more accurately

Anti-diabetic drug alogliptin meets primary endpoint in EXAMINE trial

Debiopharm starts Debio 1347 phase I study in patients with advanced solid tumors

Pre-treatment with prasugrel increases risk of bleeding without reducing risk of ischemic events

Reimbursement systems appear to impact on achievement of cholesterol lowering targets

Researchers pinpoint ways to counter effects of antibiotics-driven depletion of gut-dwelling bacteria

Holistic approach to understand and treat TB

Nanostructures made of DNA strands can encapsulate, release small-molecule drugs

Viewpoints: Tying 'social safeguards' to work may not be best policy; GOP missing an opportunity by not offering alternative to health law; food makers' health claims 'hard to swallow'

Small chemical changes to dietary flavonoids cause large effects on human immune system

Researchers identify potential drug target to recover from jet lag, disruptions in circadian system

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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