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New MIT study reveals that H3N2 strains could pose a risk to humans

In the summer of 1968, a new strain of influenza appeared in Hong Kong. This strain, known as H3N2, spread around the globe and eventually killed an estimated 1 million people.

13 May 2013

New research shows that spontaneous mutations contribute to congenital heart disease

Every year, thousands of babies are born with severely malformed hearts, disorders known collectively as congenital heart disease. Many of these defects can be repaired though surgery, but researchers don't understand what causes them or how to prevent them. New research shows that about 10 percent of these defects are caused by genetic mutations that are absent in the parents of affected children.

13 May 2013

Disease-in-a-dish models show promise for treating ataxia telangiectasia

Led by Dr. Peiyee Lee and Dr. Richard Gatti, researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have used induced pluripotent stem cells to advance disease-in-a-dish modeling of a rare genetic disorder, ataxia telangiectasia.

13 May 2013

Inherited mutations in p53 gene put people at high risk of developing cancers

The understanding of how a powerful protein called p53 protects against cancer development has been upended by a discovery by Walter and Eliza Hall Institute researchers. More than half of human cancers carry defects in the gene for p53, and almost all other cancers, with a normal p53 gene, carry other defects that somehow impair the function of the p53 protein. Inherited mutations in the p53 gene put people at a very high risk of developing a range of cancers.

10 May 2013

Mouse study shows leukemia halts accumulation of toxic proteins linked to Parkinson's disease

Researchers at Georgetown University Medical Center have used tiny doses of a leukemia drug to halt accumulation of toxic proteins linked to Parkinson's disease in the brains of mice. This finding provides the basis to plan a clinical trial in humans to study the effects.

10 May 2013

Scientists identify new way to boost gene-silencing mechanism

A team led by scientists at The Scripps Research Institute (TSRI) has found how to boost or inhibit a gene-silencing mechanism that normally serves as a major controller of cells' activities. The discovery could lead to a powerful new class of drugs against viral infections, cancers and other diseases.

10 May 2013

Fat cells in knee secrete a protein linked to arthritis

Scientists have discovered that fat cells in the knee secrete a protein linked to arthritis, a finding that paves the way for new gene therapies that could offer relief and mobility to millions worldwide.

10 May 2013

Nutritional supplement may improve survival rates of babies born with heart defects

A common nutritional supplement may be part of the magic in improving the survival rates of babies born with heart defects, researchers report. Carnitine, a compound that helps transport fat inside the cell powerhouse where it can be used for energy production, is currently used for purposes ranging from weight loss to chest pain.

10 May 2013

New test determines which children with malaria are likely to develop cerebral malaria

Researchers at Michigan State University have identified a test that can determine which children with malaria are likely to develop cerebral malaria, a much more life-threatening form of the disease.

10 May 2013

Researchers find a way the body can remove injured axons

Many medical issues affect nerves, from injuries in car accidents and side effects of chemotherapy to glaucoma and multiple sclerosis. The common theme in these scenarios is destruction of nerve axons, the long wires that transmit signals to other parts of the body, allowing movement, sight and sense of touch, among other vital functions.

10 May 2013

Children born with CDG don't contain mutation in every cell type, say Sanford-Burnham researchers

Children born with rare, inherited conditions known as Congenital Disorders of Glycosylation, or CDG, have mutations in one of the many enzymes the body uses to decorate its proteins and cells with sugars.

10 May 2013

Progenitor cells remain highly dynamic in the adult brain

By monitoring the behavior of a class of cells in the brains of living mice, neuroscientists at Johns Hopkins discovered that these cells remain highly dynamic in the adult brain, where they transform into cells that insulate nerve fibers and help form scars that aid in tissue repair.

10 May 2013

Newly engineered biomaterials could lead to possible cure for Type 1 diabetes, find researchers

Researchers have made a significant first step with newly engineered biomaterials for cell transplantation that could help lead to a possible cure for Type 1 diabetes, which affects about 3 million Americans.

10 May 2013

Research opens door to new drug therapies for Parkinson's disease

McGill University researchers have unlocked a new door to developing drugs to slow the progression of Parkinson's disease. Collaborating teams led by Dr. Edward A. Fon at the Montreal Neurological Institute and Hospital -The Neuro, and Dr. Kalle Gehring in the Department of Biochemistry at the Faculty of Medicine, have discovered the three-dimensional structure of the protein Parkin.

10 May 2013

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

In cancer, mutations in proteins that control cell growth are common, leading to unrestrained cellular proliferation and tumor formation.

9 May 2013

Trevena, Forest sign collaborative agreement to develop TRV027 for treatment of ADHF

Trevena, Inc., a clinical stage pharmaceutical company and the leader in the discovery and development of G-protein coupled receptor biased ligands, and Forest Laboratories Holding Limited, a subsidiary of Forest Laboratories Inc., an international pharmaceutical company, announced today that they have entered into a collaborative licensing option agreement for the development of TRV027, an AT1R biased-ligand that recently completed Phase 2a clinical trials.

9 May 2013

Researchers discover that microRNAs link two defining characteristics of fit muscles

Researchers discovered that small pieces of genetic material called microRNAs link the two defining characteristics of fit muscles: the ability to burn sugar and fat and the ability to switch between slow- and fast-twitch muscle fibers.

9 May 2013

Thijn Brummelkamp wins 2013 EMBO Gold Medal for genetic analysis of human disease

EMBO today announced Thijn Brummelkamp of the Netherlands Cancer Institute in Amsterdam as the winner of the 2013 EMBO Gold Medal. The award acknowledges his outstanding work to accelerate the genetic analysis of human disease.

9 May 2013

Researchers identify genetic mutations that appear to underlie rare syndrome

Researchers from Massachusetts General Hospital and Duke University have identified genetic mutations that appear to underlie a rare but devastating syndrome combining reproductive failure with cerebellar ataxia - a lack of muscle coordination - and dementia.

9 May 2013

Gene offers new insights into treatment strategies for deep-vein thrombosis

A gene associated with both protection against bacterial infection and excessive blood clotting could offer new insights into treatment strategies for deep-vein thrombosis -- the formation of a harmful clot in a deep vein.

9 May 2013

Protein C News and Research

New MIT study reveals that H3N2 strains could pose a risk to humans

New research shows that spontaneous mutations contribute to congenital heart disease

Disease-in-a-dish models show promise for treating ataxia telangiectasia

Inherited mutations in p53 gene put people at high risk of developing cancers

Mouse study shows leukemia halts accumulation of toxic proteins linked to Parkinson's disease

Scientists identify new way to boost gene-silencing mechanism

Fat cells in knee secrete a protein linked to arthritis

Nutritional supplement may improve survival rates of babies born with heart defects

New test determines which children with malaria are likely to develop cerebral malaria

Researchers find a way the body can remove injured axons

Children born with CDG don't contain mutation in every cell type, say Sanford-Burnham researchers

Progenitor cells remain highly dynamic in the adult brain

Newly engineered biomaterials could lead to possible cure for Type 1 diabetes, find researchers

Research opens door to new drug therapies for Parkinson's disease

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

Trevena, Forest sign collaborative agreement to develop TRV027 for treatment of ADHF

Researchers discover that microRNAs link two defining characteristics of fit muscles

Thijn Brummelkamp wins 2013 EMBO Gold Medal for genetic analysis of human disease

Researchers identify genetic mutations that appear to underlie rare syndrome

Gene offers new insights into treatment strategies for deep-vein thrombosis

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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