Chloroquine News and Research

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Artemisinin combination therapies have potential to be one of the major public health interventions for Africa in this decade

Despite changes in policy in many African countries, most cases of malaria are still treated with old drugs that often fail, say researchers the British Medical Journal.

3 Oct 2005

Drug that blocks acid buildup inside cells revs up the immune response to vaccines

Reporting in the current issue of The Journal of Experimental Medicine, Vincenzo Barnaba and his team at the University of Rome show that people receiving booster shots against hepatitis B virus developed more robust immune responses if given a widely used anti-malaria drug called chloroquine.

21 Sep 2005

WHO urges responsible use of antimalarial medicines

In a new report published today, ''Susceptibility of Plasmodium Falciparum to Antimalarial Drugs,'' the World Health Organization (WHO) warns that as more and more people gain access to these life-saving malaria medicines, which combine a drug derived from the plant Artemisia annua with a second, synthetic drug, it is vital that countries closely monitor their effectiveness.

7 Sep 2005

HIV/AIDS drugs may also be effective against malaria

Researchers at The Queensland Institute of Medical Research (QIMR) have found that drugs used to treat HIV Aids may also be effective against the biggest killer in the world - malaria.

2 Jun 2005

Malaria still biggest killer of children in Africa

According to new report by the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF), progress has been made in preventing and treating malaria since 2000 and more countries are introducing the latest preventative measures to beat the disease.

4 May 2005

International coalition works to develop a cocktail of drugs to combat Malaria

As Africa marks its own Malaria Day in recognition of the fact that it bears 90% of the deadly disease’s burden, an international research coalition is working to develop a cocktail of drugs that overcomes increasing resistance to conventional treatment exhibited by the elusive parasite.

27 Apr 2005

Anti-malarial drug combo could help address malaria crisis in Africa

Using a combination of two drugs—artemether and lumefantrine—is the most effective way to treat malaria in the areas of Africa where resistance to commonly used malaria drugs is high, concludes a randomised trial published in this week’s issue of The Lancet.

21 Apr 2005

Drug combination of amodiaquine and sulfadoxinepyrimethamine might offer the optimal treatment for malaria

Results of a randomised trial from Uganda in this week’s issue of THE LANCET suggest that the drug combination of amodiaquine and sulfadoxinepyrimethamine might offer the optimal treatment for malaria in terms of efficacy and cost-effectiveness in this region.

29 Nov 2004

Sharply increased demand for artemether-lumefantrine, used to treat malaria, is likely to result in a shortage

Sharply increased demand for artemether-lumefantrine, an artemisinin-based combination therapy (ACT) used to treat malaria, is likely to result in a shortage from now until at least March 2005. ACTs are currently the most effective medicines available to treat falciparum malaria -- the deadliest form of the disease.

9 Nov 2004

Protease inhibitors used to treat HIV-1 infection may also be effective for treatment or prevention of malaria

The study found protease inhibitors inhibited the growth of P. falciparum, the malaria parasite that causes most disease. These findings may also expose a previously unexplored vulnerability in the parasite that could lead to a new class of anti-malarial drug.

8 Nov 2004

Breakthrough discovery on why the malaria parasite has become resistant to chloroquine

Scientists at the Liverpool School of Tropical Medicine have made a major breakthrough in discovering why the malaria parasite Plasmodium Falciparum, deposited in humans by the mosquito, has become resistant to chloroquine

23 Sep 2004

Widely used antimalarial drug exhibits antiviral activity against the SARS

Virologists from the Katholieke Universiteit Leuven in Belgium report that chloroquine, a widely used antimalarial drug, exhibits antiviral activity against the SARS coronavirus. Chloroquine is an inexpensive and safe drug available worldwide.

5 Sep 2004

Antimalarial drug resistance is an international problem that requires a co-ordinated, international response

Imported resistance has rendered ineffective the two affordable malaria drugs which have been the mainstay of malaria treatment in Africa for forty years, according to experts writing today in the journal Science.

20 Aug 2004

Malaria mortality rate in Africa and Asia could double in a few decades as the drug used most frequently is rendered useless

Within the next five years, international organizations and world leaders should begin collectively to contribute $300 million to $500 million annually to create a global subsidy that would make new combination malaria treatments available to the world's poor for as little as 10 cents per treatment course

23 Jul 2004

New Caledonian sponges produce antimalarial substances

Marine organisms synthesize many different substances, some of which possess anticarcinogenic, antiviral or antiparasitic properties.

22 Jul 2004

U.S. team to battle malaria in Peru

In the middle of the Peruvian Amazon, a battle against malaria – the second largest killer of people worldwide – will be undertaken by an international team of researchers led by tropical disease specialist Joseph Vinetz, M.D., from the University of California, San Diego (UCSD) School of Medicine.

11 Jun 2004

Study finds malaria drug does not affect the ability of airline crew to perform their duties

Results from a new study presented today at the 75th Annual Scientific Meeting of the Aerospace Medical Association (AsMA) in Anchorage, USA, suggest that MalaroneTM (atovaquone and proguanil hydrochloride) would not be expected to affect the ability of pilots and cabin crew to perform their duties while on an aircraft.

6 May 2004

GSK and WHO collaborate to fight malaria

GlaxoSmithKline (GSK), the World Health Organisation's Special Programme for Research and Training in Tropical Diseases (WHO-TDR) and the Medicines for Malaria Venture (MMV) today announced the signing of a collaborative agreement, to develop a new-fixed dose artemisinin combination therapy drug (ACT), combining chlorproguanil, dapsone and artesunate (CDA) for the treatment of malaria.

23 Apr 2004

WHO renews call for effective malaria treatment

More than 600 million people, most of them children living in sub-Saharan Africa, face the daily threat of death from malaria because new, effective treatments are not available where they live. Existing, cheaper medicines, which have been used for many years, are no longer effective in most places because the malaria parasite has developed resistance to them.

22 Apr 2004

Almost half of all medicines globally are used irrationally according to WHO

Almost half of all medicines globally are used irrationally. This, say medicines experts at the World Health Organization (WHO), can have severe consequences: adverse drug reactions, drug resistance, protracted illness and even death. In addition, the financial cost incurred by individuals and governments due to irrational use is unnecessary and often extremely high, particularly in developing countries where patients often pay for medicines out of pocket.

29 Mar 2004