Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Viral load reduction effectiveness of SARS-CoV-2 BNT162b2 mRNA booster vaccine wanes with time

In a new study, researchers conducted a retrospective analysis of the SAR-CoV-2 reverse transcriptase - quantitative polymerase chain reaction test measurements.

9 Mar 2022

Relationship between immunological responses in the acute phase of SARS-CoV-2 infection and long-term cognitive deficits

A recent study reported that monocytosis during the acute phase of coronavirus disease 2019 could forecast anosognosia in long COVID.

8 Mar 2022

Researchers develop scoring tools to determine hospitalization and mortality risk in COVID-19 patients

Researchers conducted a large retrospective study on a cohort of severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 patients, developing and validating a simple and precise scoring tool to risk stratify COVID-19 ambulatory and emergency department patients for subsequent hospitalizations and mortalities.

8 Mar 2022

Study explores COVID-19 vaccine effectiveness in ankylosing spondylitis patients

Researchers estimated the immunogenicity of SARS-CoV-2 vaccination in a Belgian cohort of patients with ankylosing spondylitis.

7 Mar 2022

Third dose of COVID mRNA vaccine safe and effective in kidney transplant patients

An new study reports that a third dose of the Pfizer BNT162b2 vaccine produces high levels of anti-spike IgG antibodies in kidney transplant recipients.

6 Mar 2022

Adenosine receptor agonists provide therapeutic target in mouse SARS-CoV-2 infection

A new study describes the efficacy of adenosine receptor agonists in the treatment of SARS-CoV-2 infection.

2 Mar 2022

Declining immune responses against SARS-CoV-2 variants in dialysis patients post-vaccination

Researchers examined systemic B and T cell responses 16 weeks after BNT162b2 vaccination, and the potency of vaccine-induce neutralizing antibodies, in hemodialysis patients and healthcare workers with no comorbidities.

25 Feb 2022

Study on Omicron related mortality in cancer patients during recent COVID wave

A recent pre-proof study published in the journal Cancer Cell assessed the CFR of cancer patients during the third wave of the coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 Omicron variant.

23 Feb 2022

Merkel cell carcinoma has a higher post-treatment recurrence rate than other skin cancers

Patients treated for Merkel cell carcinoma (MCC) face a five-year recurrence rate of 40% - markedly higher than the recurrence rates for melanoma and other skin cancers, according to research published today in JAMA Dermatology.

23 Feb 2022

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

The role played by the host enzyme TMPRSS2 in infection and cancer is the focus of a new study.

23 Feb 2022

REGEN-COV antibody combination to prevent COVID-19 severity

A new study assessed the effectiveness of REGEN-COV, a combination of casirivimab and imdevimab monoclonal antibodies, in the prevention of COVID-19 disease severity.

22 Feb 2022

Prevalence of chemosensory loss induced by SARS-CoV-2 Omicron variant in Italy

Researchers conducted a prospective cohort study to determine the prevalence of chemosensory dysfunction in mild to moderate COVID-19 patients in Italy.

22 Feb 2022

Drugs that increase fetal hemoglobin levels may help people with sickle cell disease

Sickle cell anemia is an inherited blood disorder where red blood cells become sickle/crescent shaped. It causes frequent infections, swelling in the hands and legs, pain, severe tiredness and delayed growth or puberty.

18 Feb 2022

Study helps understand actionable genetic variation affecting drugs in the Middle East population

A group of researchers at Qatar Foundation have reported the first comprehensive study of the distribution of actionable genetic variation affecting drugs in any Middle Eastern population, with potential implications for preemptive pharmacogenomic implementation in the region.

16 Feb 2022

Children with severe COVID-19 show low mucosal neutralizing activity against SARS-CoV-2

A new study examines neutralizing responses to the ancestral variant of SARS-CoV-2, as well as against later variants of concern.

16 Feb 2022

Real-world data on efficacy and safety of COVID vaccines in Canada

In a recent study posted to the medRxiv* preprint server, researchers evaluated the efficacy and safety of the coronavirus disease 2019 (COVID-19) vaccines in young and elderly cohorts from Canada.

14 Feb 2022

Next era of transplantation is on the horizon, transplant chief says

Satish Nadig, MD, PhD, the Edward G. Elcock Professor of Surgical Research and director of the Comprehensive Transplant Center (CTC), said he arrived at Feinberg in November 2021 with a mission statement: "to have patient-centric impact through quality innovation and education."

8 Feb 2022

Immunosuppression News and Research

Further Reading

Viral load reduction effectiveness of SARS-CoV-2 BNT162b2 mRNA booster vaccine wanes with time

Relationship between immunological responses in the acute phase of SARS-CoV-2 infection and long-term cognitive deficits

Researchers develop scoring tools to determine hospitalization and mortality risk in COVID-19 patients

Study explores COVID-19 vaccine effectiveness in ankylosing spondylitis patients

Third dose of COVID mRNA vaccine safe and effective in kidney transplant patients

Adenosine receptor agonists provide therapeutic target in mouse SARS-CoV-2 infection

Declining immune responses against SARS-CoV-2 variants in dialysis patients post-vaccination

Study on Omicron related mortality in cancer patients during recent COVID wave

Merkel cell carcinoma has a higher post-treatment recurrence rate than other skin cancers

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

REGEN-COV antibody combination to prevent COVID-19 severity

Prevalence of chemosensory loss induced by SARS-CoV-2 Omicron variant in Italy

Drugs that increase fetal hemoglobin levels may help people with sickle cell disease

Study helps understand actionable genetic variation affecting drugs in the Middle East population

Children with severe COVID-19 show low mucosal neutralizing activity against SARS-CoV-2

Real-world data on efficacy and safety of COVID vaccines in Canada

Next era of transplantation is on the horizon, transplant chief says

Safety and immunogenicity of high-dose quadrivalent influenza vaccine and mRNA-1273 vaccine booster in older adults

Quantitative framework to investigate the dynamic mechanism of host immune response confronting SARS-CoV-2 infection

Response to COVID-19 vaccine booster in seronegative kidney transplant recipients

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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