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Periodontal bacterial load associated with disease severity in multiple sclerosis

Increasing evidence suggests that the severe gum disease, periodontitis, may contribute to central nervous system disorders through chronic inflammation.

30 Dec 2025

Vagus nerve may hold the key to a younger and healthier heart

The secret to a healthier and "younger" heart lies in the vagus nerve. A recent study coordinated by the Sant'Anna School of Advanced Studies in Pisa and published in Science Translational Medicine has shown that preserving bilateral cardiac vagal innervation is an anti-aging factor.

26 Dec 2025

Neuronal master switch reshapes brain activity during learning

Memories and learning processes are based on changes in the brain's neuronal connections and, as a result, in signal transmission between neurons.

23 Dec 2025

Skin and internal organs sense cold through different molecular pathways

A research team led by Félix Viana, co-director of the Sensory Transduction and Nociception laboratory at the Institute for Neurosciences (IN), a joint research centre of the Spanish National Research Council (CSIC) and Miguel Hernández University of Elche (UMH), has demonstrated that the body uses different molecular mechanisms to detect cold in the skin and in internal organs.

19 Dec 2025

New research reveals a hidden source of cellular bioelectricity

Many biological processes are regulated by electricity-from nerve impulses to heartbeats to the movement of molecules in and out of cells.

19 Dec 2025

New grant supports research into drug-induced brain toxicity

Important FDA-approved drugs to treat HIV and cancer can save lives, but they come with their own risks. Some drugs used clinically are known to cause neurological side effects in up to half of patients, ranging from confusion and memory problems to permanent nerve damage.

19 Dec 2025

Estrogen drives gut pain and explains higher rates of IBS in women

Women are dramatically more likely than men to suffer from irritable bowel syndrome (IBS), a chronic condition causing abdominal pain, bloating, and digestive discomfort.

18 Dec 2025

Experimental drug targets early toxic amyloid to slow Alzheimer’s disease

An experimental drug developed at Northwestern University has demonstrated further promise as an early intervention for Alzheimer's disease.

18 Dec 2025

New research highlights varied cold perception across body tissues

Universidad Miguel Hernández de Elche A research team led by Félix Viana, co-director of the Sensory Transduction and Nociception laboratory at the Institute for Neurosciences (IN), a joint research center of the Spanish National Research Council (CSIC) and Miguel Hernández University of Elche (UMH), has demonstrated that the body uses different molecular mechanisms to detect cold in the skin and in internal organs.

18 Dec 2025

Researchers decipher anti-MOG antibody construction, paving way for therapies

MOG Antibody-associated Disease (MOGAD) is a rare autoimmune disease of the central nervous system. The blood of patients contains antibodies against myelin oligodendrocyte glycoprotein (MOG), a protein in the myelin layer that surrounds the neurons in the brain. It is believed that these antibodies contribute to the destruction of this protective layer in the brain.

18 Dec 2025

Distant astrocytes found to play a key role in spinal cord repair

Cedars-Sinai investigators have discovered a healing mechanism that could one day be harnessed to help treat patients with spinal cord injuries, stroke, and neurological conditions such as multiple sclerosis.

17 Dec 2025

Brain structural changes linked to chronic PTSD in World Trade Center responders

New research among World Trade Center (WTC) responders with chronic post-traumatic stress disorder (PTSD) has uncovered measurable physical changes in their brain structure, consistent with changes in the balance of myelinated to unmyelinated neurons (fast- and slow-conducting nerve cells) across both hemispheres of the brain.

17 Dec 2025

Hyperphosphorylated tau may help protect the brain from infection

One of the main proteins that contributes to Alzheimer's disease is called phospho-tau (p-tau). When p-tau gets too many phosphate groups attached to it (a process called hyperphosphorylation), it starts to stick together and form clumps called "tangles" inside of brain nerve cells.

17 Dec 2025

A multi-gene mouse model reveals new mechanisms of Hirschsprung disease

During development of the digestive system, a complex network of nerves forms around it, creating a "second brain" - the enteric nervous system (ENS) - which controls the movement of food and waste through the gut.

16 Dec 2025

Hydrogel-based treatment achieves innervation and pulp-dentin regeneration

The dental pulp is susceptible to microbial infection, which often results in inflammation, necrosis, and defects in the pulp-dentin complex. Traditional treatment strategies suffer from multiple limitations and do not promote neural regeneration.

16 Dec 2025

Researchers explore how the visual brain system recovers following traumatic injury

The brain shows a capacity to recover from traumatic injury, which somewhat contradicts the widely accepted idea that neurons do not regenerate.

15 Dec 2025

Lipoic acid shows limited benefit in progressive multiple sclerosis

The over-the-counter supplement lipoic acid may have a small beneficial effect in slowing the loss of gray matter in the brains of people with progressive forms of multiple sclerosis, according to new research led by Oregon Health & Science University and the Portland VA Health Care System.

15 Dec 2025

Gut bacteria mimicry can accelerate the progression of multiple sclerosis

If gut bacteria are too similar to the protective layer of nerves, they can misdirect the immune system and cause it to attack its own nervous system.

15 Dec 2025

Dinutuximab beta plus chemotherapy shrinks neuroblastoma tumors in children

Children with a rare form of cancer called neuroblastoma which hasn't responded to initial treatment or that has relapsed may benefit from adding antibody treatment to usual chemotherapy, according to new results from a clinical trial.

12 Dec 2025

Over-contracted gut muscles drive gastrointestinal symptoms in myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also affects other organs, including the brain, heart and gastrointestinal (GI) tract.

12 Dec 2025