Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Antibodies essential for dendritic cell maturation

Dendritic cells, or DCs for short, perform a vital role for the immune system: They engulf pathogens, break them down into their component parts, and then display the pieces on their surface.

23 Jan 2013

Itch-specific nerve cells: an interview with Associate Professor Xinzhong Dong

Itch was actually defined by a German physician more than 350 years ago. His name was Samuel Hafenreffer. He defined itch as an unpleasant sensation that makes people want to scratch. You probably think this is a very simple definition but itch is really a very complex sensory modality.

21 Jan 2013

Penn Medicine to establish new center for treatment and research of blood diseases

Penn Medicine will establish the Philadelphia region's first dedicated center for the treatment and research of blood diseases by combining the expertise of physicians who specialize in the care of blood disorder patients of all ages along with basic science and clinical researchers who are working to advance treatments for these illnesses.

18 Jan 2013

Sabutoclax appears to selectively target leukemia stem cells that are responsible for relapses

Researchers at the University of California, San Diego School of Medicine have discovered that hard-to-reach, drug-resistant leukemia stem cells (LSCs) that overexpress multiple pro-survival protein forms are sensitive - and thus vulnerable - to a novel cancer stem cell-targeting drug currently under development.

18 Jan 2013

Preterm infants with slower growth have delayed development in the cerebral cortex

Preterm infants who grow more slowly as they approached what would have been their due dates also have slower development in an area of the brain called the cerebral cortex, report Canadian researchers in a new study published today in Science Translational Medicine.

17 Jan 2013

Scientists to investigate how cancer cells hide to avoid chemotherapy drugs

Scientists hope to improve leukaemia treatment by investigating how cancer cells use 'hiding places' in the body to avoid chemotherapy drugs.

17 Jan 2013

Over-expression of NEK2 in cancer cells significantly enhances drug resistance

Increased NEK2 gene expression linked to increased drug resistance, faster cancer growth, and poorer patient outcome - The finding may improved diagnostic and prognostic tools for cancer care and could lead to improved cancer therapies

16 Jan 2013

Knee cartilage repair success with new biomaterial

In a small study, researchers reported increased healthy tissue growth after surgical repair of damaged cartilage if they put a “hydrogel” scaffolding into the wound to support and nourish the healing process. The squishy hydrogel material was implanted in 15 patients during standard microfracture surgery, in which tiny holes are punched in a bone near the injured cartilage. The holes stimulate patients’ own specialized stem cells to emerge from bone marrow and grow new cartilage atop the bone.

15 Jan 2013

Vitamin D claims for knee osteoarthritis questioned

The benefit of taking vitamin D supplements for the treatment of knee osteoarthritis has been challenged in a study published in JAMA.

14 Jan 2013

Clinical trials aim to repair bones using adult stem cells combined with biomaterials

The clinical trials aim to repair bones using adult stem cells combined with biomaterials. It will be conducted in France in the Cr-teil University Hospital Centre and the Regional University Hospital Centre in Tours, in collaboration with the French Blood Establishment.

10 Jan 2013

CTI initiates enrollment in pacritinib Phase 3 trial for myelofibrosis

Cell Therapeutics, Inc. (CTI) today announced that the Company has initiated clinical trial sites and began enrolling patients in a Phase 3 clinical trial, known as PERSIST-1 or PAC325, for pacritinib, CTI's investigational JAK2 inhibitor, which is being evaluated for the treatment of patients with myelofibrosis.

9 Jan 2013

Markey practitioner receives Lexington Cancer Foundation grant to continue JSJ program

The University of Kentucky Markey Cancer Center's Jennifer Bradley has received funding from the Lexington Cancer Foundation to continue the Jin Shin Jyutsu program in 2013.

4 Jan 2013

Heart attack patients may benefit from mild to moderate sleep-disordered breathing

People who suffer from breathing disorders such as sleep apnea are usually at higher risk for cardiovascular disease. But an intriguing new study from Technion-Israel Institute of Technology scientists suggests that some heart attack patients with these conditions may actually benefit from mild to moderate sleep-disordered breathing.

3 Jan 2013

Soligenix's OrbeShield granted FDA oral BDP orphan drug designation

Soligenix, Inc., a development stage biopharmaceutical company, announced today that the Office of Orphan Products Development of the US Food and Drug Administration (FDA) has granted orphan drug designation to OrbeShield (oral beclomethasone 17,21-dipropionate or oral BDP) for the prevention of death following a potentially lethal dose of total body irradiation during or after a radiation disaster.

2 Jan 2013

New Nationwide Children's exercise program for pediatric cancer survivors

There are many health effects that a patient may need to overcome after winning a battle against cancer. Cancer treatments can affect the patient's balance, agility, coordination, prompt weight gain and other physical ailments. At Nationwide Children's Hospital, beating cancer doesn't mark the end of a child's treatment regimen. A new exercise program at the hospital helps pediatric cancer survivors and those in remission regain both physical strength and confidence.

21 Dec 2012

Real estate businessman delivers $2.5M gift to University of Chicago Medicine for GI study

Real estate businessman Seymour "Sy" Taxman and his wife, Nancy, presented a gift of $2.5 million to the University of Chicago Medicine on Wednesday in honor of the late Joseph B. Kirsner, MD, PhD, the Louis Block Distinguished Service Professor of Medicine and a pioneer in the research and treatment of digestive disease.

21 Dec 2012

Study examines role of race and ethnicity in stem cell donation

New research examining the role of race and ethnicity in an individual's decision to become a donor for hematopoietic cell transplantation (HCT) identifies several factors associated with varied participation rates in national donor registries across racial/ethnic groups. Results of this first-of-its-kind study are published online today in Blood, the Journal of the American Society of Hematology (ASH).

21 Dec 2012

Study examines five varieties of cells after transplantation in the CNS

When different types of cells are transplanted with the intent of having them aid in repairing central nervous system (CNS) trauma, what is the fate and function of those cells? A Belgian research team carried out research aimed at answering this question by determining how five varieties of cells - neural stem cells, mouse embryonic fibroblasts, dendritic cells, bone marrow mononuclear cells (BMMNCs) and splenocytes - functioned and survived after transplantation in the CNS.

21 Dec 2012

Two hematology/oncology pharmacists to receive 2012 HOPA Foundation Research Award

The HOPA Foundation Board of Directors is pleased to announce the recipients of the 2012 HOPA Foundation Research Award, Dr. Kamakshi Rao for her project Improving & Defining the Impact & Value of Pharmacists in Stem Cell Transplant, and to Dr. Quan Li, for his project, In Vitro Stability of Erlotinib, Lapatinib and Imatinib in Common Compounding Vehicles.

15 Dec 2012

Ibrutinib continues to show unprecedented results in patients with mantle cell lymphoma

An international study of ibrutinib in people with relapsed or refractory mantle cell lymphoma (MCL) continues to show unprecedented and durable results with few side effects.

15 Dec 2012

Bone Marrow News and Research

Further Reading

Antibodies essential for dendritic cell maturation

Itch-specific nerve cells: an interview with Associate Professor Xinzhong Dong

Penn Medicine to establish new center for treatment and research of blood diseases

Sabutoclax appears to selectively target leukemia stem cells that are responsible for relapses

Preterm infants with slower growth have delayed development in the cerebral cortex

Scientists to investigate how cancer cells hide to avoid chemotherapy drugs

Over-expression of NEK2 in cancer cells significantly enhances drug resistance

Knee cartilage repair success with new biomaterial

Vitamin D claims for knee osteoarthritis questioned

Clinical trials aim to repair bones using adult stem cells combined with biomaterials

CTI initiates enrollment in pacritinib Phase 3 trial for myelofibrosis

Markey practitioner receives Lexington Cancer Foundation grant to continue JSJ program

Heart attack patients may benefit from mild to moderate sleep-disordered breathing

Soligenix's OrbeShield granted FDA oral BDP orphan drug designation

New Nationwide Children's exercise program for pediatric cancer survivors

Real estate businessman delivers $2.5M gift to University of Chicago Medicine for GI study

Study examines role of race and ethnicity in stem cell donation

Study examines five varieties of cells after transplantation in the CNS

Two hematology/oncology pharmacists to receive 2012 HOPA Foundation Research Award

Ibrutinib continues to show unprecedented results in patients with mantle cell lymphoma

Industry Focus eBook - Cell biology (5th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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