Immune Response News and Research

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Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

Biliary atresia is a rare disease that occurs when a delicate tree-like set of ducts that carry bile from the liver to the intestine becomes scarred and blocked. While some treatments can slow the damage, most children who develop biliary atresia will die without a liver transplant.

10 Jan 2022

SARS-CoV-2 levels decrease when human SIRT5 is deleted or inhibited

Researchers examine the role of human sirtuin 5 (SIRT5) in SARS-CoV-2 infection.

10 Jan 2022

Scientists unravel how blood cells mount the first line of defense against viruses

Scientists have just slotted into place a big piece of the puzzle that explains how our blood cells mount their first line of defense against viruses.

10 Jan 2022

Hybrid immunity shown to offer sub-optimal protection against SARS-CoV-2 Omicron variant

In a new study, researchers evaluated the neutralizing power of the vaccine against SARS-CoV-2 and vaccine plus infection-induced antibodies against the Omicron variant in a live virus neutralization assay.

10 Jan 2022

Mapping regulatory T-cell populations in COVID-19 patients

In a new study, researchers used mass spectrometry to investigate changes to immune systems, in particular regulatory T-cells (Tregs), in a large cohort of moderate, severe, and critical Japanese coronavirus disease 2019 (COVID-19) patients and healthy controls.

10 Jan 2022

T cells induced by common cold coronaviruses play a protective role against COVID-19 infection

A new study, published in Nature Communications and led by Imperial College London researchers, provides the first evidence of a protective role for these T cells.

10 Jan 2022

Durability of vaccine protection against COVID-19 breakthrough infections and hospitalizations

In a new study, researchers investigated the duration of protection provided by the coronavirus disease 2019 vaccines available in the United States against breakthrough infections, hospitalizations, and intensive care unit admissions.

10 Jan 2022

Humoral and cellular response to primary and booster COVID-19 vaccination in immunosuppressed patients

Researchers posted the results of a retrospective observational cohort study in which they determined the humoral and cellular responses in ISP to primary and booster doses of COVID-19 vaccines.

10 Jan 2022

SARS-CoV-2 shown to spread through cell-to-cell transmission

A new study investigated SARS-CoV-2 cell-to-cell transmission in the context of cell-free infection and compared it to SARS-CoV.

10 Jan 2022

History of SARS-CoV-2 infection affects longitudinal responses to BNT162b2 vaccine

In a recently published article in the journal Cell Reports, scientists have demonstrated that individuals with or without a history of coronavirus disease 2019 (COVID-19) exhibit differential humoral and cellular immune responses 14 days after receiving mRNA-based COVID-19 vaccine developed by Pfizer/BioNTech. However, at a later time point, the responses become comparable between the two groups.

9 Jan 2022

Vaccinated mothers transfer SARS-CoV-2 antibodies to their breastfed infants

Women vaccinated against COVID-19 transfer SARS-CoV-2 antibodies to their breastfed infants, potentially giving their babies passive immunity against the coronavirus, according to University of Massachusetts Amherst research.

7 Jan 2022

Omicron variant found to be much less sensitive to neutralizing antibodies than Delta

The Omicron variant was detected for the first time in South Africa in November 2021 and has since spread to many countries.

7 Jan 2022

Researchers investigate SARS-CoV-2 specific inflammatory response

New research can confirm that while some of the response from monocytes to SARS-CoV-2 is generic to virus infection, most of it SARS-CoV-2 specific, especially proinflammatory responses.

7 Jan 2022

Scrapping many Covid testing measures is a grave mistake, says London Medical Laboratory

London Medical Laboratory warns that its testing reveals nearly one in five people still have insufficient Covid antibodies.

7 Jan 2022

Grouping tumors by 'immune archetypes' points the way to personalized immunotherapies

The UCSF researchers, led by first co-authors Alexis Combes, PhD, and Bushra Samad, MS, and senior author, Max Krummel, PhD, obtained tumor specimens from 78 UCSF clinicians, and surveyed 364 tumors biopsies from patients and categorized them into groups based on their immune microenvironment.

7 Jan 2022

Host kinase identified as an inhibition target for SARS-CoV-2

In this experiment, the chemical probe SGC-CK2-1 inhibited virus replication at nanomolar concentration, showing a highly selective effect on the kinase.

6 Jan 2022

Serological antibody response to SARS-CoV-2 infection at a population level

The scientists in this study used pooled convalescent serum to examine the serologic response in a population at risk of infection.

6 Jan 2022

SARS-CoV-2 appears to persist in organs throughout the body for months

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leads to asymptomatic or mild symptoms in most cases. However, in a significant minority, it causes moderate or severe disease, with lung damage and sometimes multi-organ dysfunction, the origin of which is currently a matter of intense debate.

6 Jan 2022

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

The LIVE-AIR phase 3 clinical trial is associated with early treatment of hyperinflammatory response with the humanized monoclonal antibody lenzilumab in COVID-19 patients with decreased oxygen saturation. The study results are posted to the medRxiv* preprint server.

6 Jan 2022

A new model for predicting COVID-19 severity at diagnosis

Researchers estimate the probabilities of hospitalization and mortality from COVID-19 according to individual risk factors and number of vaccine doses.

5 Jan 2022

Immune Response News and Research

Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

SARS-CoV-2 levels decrease when human SIRT5 is deleted or inhibited

Scientists unravel how blood cells mount the first line of defense against viruses

Hybrid immunity shown to offer sub-optimal protection against SARS-CoV-2 Omicron variant

Mapping regulatory T-cell populations in COVID-19 patients

T cells induced by common cold coronaviruses play a protective role against COVID-19 infection

Durability of vaccine protection against COVID-19 breakthrough infections and hospitalizations

Humoral and cellular response to primary and booster COVID-19 vaccination in immunosuppressed patients

SARS-CoV-2 shown to spread through cell-to-cell transmission

History of SARS-CoV-2 infection affects longitudinal responses to BNT162b2 vaccine

Vaccinated mothers transfer SARS-CoV-2 antibodies to their breastfed infants

Omicron variant found to be much less sensitive to neutralizing antibodies than Delta

Researchers investigate SARS-CoV-2 specific inflammatory response

Scrapping many Covid testing measures is a grave mistake, says London Medical Laboratory

Grouping tumors by 'immune archetypes' points the way to personalized immunotherapies

Host kinase identified as an inhibition target for SARS-CoV-2

Serological antibody response to SARS-CoV-2 infection at a population level

SARS-CoV-2 appears to persist in organs throughout the body for months

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

A new model for predicting COVID-19 severity at diagnosis

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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