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Study suggests new ways to treat neurological symptoms linked to tuberous sclerosis complex

Boston Children's Hospital researchers have uncovered a new molecular pathway that inhibits the myelination of neurons in the brains of patients with the rare genetic disorder tuberous sclerosis complex.

9 Feb 2017

New therapeutic agent shows potential for treating optic neuritis linked to multiple sclerosis

A new therapeutic agent tested in a mouse model of multiple sclerosis (MS) produced anti-inflammatory activity and prevented loss of cells in the optic nerve, according to a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania, with Pittsburgh-based Noveome Biotherapeutics.

9 Feb 2017

New study uncovers important links between glioblastoma and epileptic seizures

Detecting brain tumors at the earliest possible stage and eliminating them before seizures begin might be possible one day, according to research by scientists at Baylor College of Medicine and Texas Children's Hospital.

7 Feb 2017

Scientists show how immune receptor activated by bacteria contributes to diabetic bladder dysfunction

Bladder dysfunction is a reality for about half of patients with diabetes and now scientists have evidence that an immune system receptor that's more typically activated by bacteria is a major contributor.

7 Feb 2017

Northwestern Medicine scientists discover retinal cell that may cause myopia

Northwestern Medicine scientists have discovered a cell in the retina that may cause myopia when it dysfunctions. The dysfunction may be linked to the amount of time a child spends indoors and away from natural light.

6 Feb 2017

Scientists discover treatment that improves symptoms in mouse model of juvenile Batten disease

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and King's College London have discovered a treatment that improves the neurological symptoms in a mouse model of juvenile Batten disease.

6 Feb 2017

Penn scientists find cytokine as key to fighting and treating viral infection in the lungs

Viral infections that occur in a patient's lungs are a significant cause of hospitalization and death among children and the elderly.

3 Feb 2017

NIH researchers shed light on role of S. epidermidis toxin in bacterial sepsis

Staphylococcus epidermidis bacteria are a significant health concern for hospitalized infants, children and anyone with implanted medical devices.

2 Feb 2017

New study offers insights into how antidepressants work in the brain

When they work, antidepressant medications may take weeks or months to alleviate symptoms of depression.

2 Feb 2017

Glucose deprivation in the brain triggers onset of cognitive decline, research shows

One of the earliest signs of Alzheimer's disease is a decline in glucose levels in the brain. It appears in the early stages of mild cognitive impairment -- before symptoms of memory problems begin to surface.

31 Jan 2017

Study reveals new molecular mechanism vital for associative memory encoding in the hippocampus

A new study, published on the cover of the scientific journal Biological Psychiatry and lead by Dr Carlos Saura from the Institut de Neurociències at the Universitat Autònoma de Barcelona, reveals a new molecular mechanism essential for associative memory encoding in the hippocampus.

31 Jan 2017

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

A handful of FDA-approved drugs exist for treating individuals with alcohol use disorder but they have been largely ineffective at reducing the high rates of relapse. As such, there remains a critical need to identify and develop alternative pharmacological treatment options.

31 Jan 2017

Research findings could lead to effective repair therapies for peripheral nerve damage

Research published today, 30th January 2017 online in the Journal of Cell Biology, has for the first time identified how a bodily protein allows nerves of the peripheral nervous system (PNS) to repair following injury.

30 Jan 2017

Bacterial by-product helps correct gut microbiome imbalance in mouse model of ALS

A bacterial by-product known to be important in maintaining gut health may slow the progression of amyotrophic lateral sclerosis, or ALS - a progressive, neurodegenerative disease.

27 Jan 2017

Old tuberculosis drug improves impaired social behavior in autism mouse model

Reducing the function of the autism-associated gene Pcdh10 leads to impairments in social behavior, according to a study published in Biological Psychiatry.

26 Jan 2017

Prenatal infection-induced epigenetic modifications may alter brain development in offspring

Maternal infection during pregnancy increases the risk for psychiatric disorders in the child, but the path between the two is something of a mystery.

25 Jan 2017

Scientists discover cause of tumour resistance to angiogenesis inhibitors

A new study conducted by MedUni Vienna in collaboration with scientists from Hungary and Sweden has now shown for the first time that the success of specialised drugs to inhibit blood supply to tumours - so-called angiogenesis inhibitors - is compromised by the fact that these drugs do not effectively penetrate the tumour tissue and so do not reach the smallest blood vessels in the tumour.

25 Jan 2017

UAB researchers discover novel underlying mechanism involved in anxiety disorders, PTSD

University of Alabama at Birmingham neurobiologist Lynn Dobrunz, Ph.D., has discovered a novel mechanism for how stress-induced anxiety — the type of experience that can produce post-traumatic stress disorder, or PTSD — affects circuit function in the hippocampus, the area of the brain where aversive memories are formed.

24 Jan 2017

Tulane researchers discover cancer-causing role of protein thought to be tumor suppressor

Tulane University researchers have discovered that the protein PHLDB3, thought to be a potential tumor suppressor, actually allows cancer cells to thrive in pancreatic, prostate, colon, breast, lung, and other common cancers.

24 Jan 2017

Researchers investigate influence of surrounding tissue on formation and growth of tumor cells

Malignant melanoma is the fastest-growing type of cancer and the most fatal skin disease.

23 Jan 2017

Mouse Model News and Research

Study suggests new ways to treat neurological symptoms linked to tuberous sclerosis complex

New therapeutic agent shows potential for treating optic neuritis linked to multiple sclerosis

New study uncovers important links between glioblastoma and epileptic seizures

Scientists show how immune receptor activated by bacteria contributes to diabetic bladder dysfunction

Northwestern Medicine scientists discover retinal cell that may cause myopia

Scientists discover treatment that improves symptoms in mouse model of juvenile Batten disease

Penn scientists find cytokine as key to fighting and treating viral infection in the lungs

NIH researchers shed light on role of S. epidermidis toxin in bacterial sepsis

New study offers insights into how antidepressants work in the brain

Glucose deprivation in the brain triggers onset of cognitive decline, research shows

Study reveals new molecular mechanism vital for associative memory encoding in the hippocampus

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

Research findings could lead to effective repair therapies for peripheral nerve damage

Bacterial by-product helps correct gut microbiome imbalance in mouse model of ALS

Old tuberculosis drug improves impaired social behavior in autism mouse model

Prenatal infection-induced epigenetic modifications may alter brain development in offspring

Scientists discover cause of tumour resistance to angiogenesis inhibitors

UAB researchers discover novel underlying mechanism involved in anxiety disorders, PTSD

Tulane researchers discover cancer-causing role of protein thought to be tumor suppressor

Researchers investigate influence of surrounding tissue on formation and growth of tumor cells

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