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Advance team of molecules produced by primary tumor is responsible for lung cancer metastasis

Cancer metastasis requires tumor cells to acquire properties that allow them to escape from the primary tumor site, travel to a distant place in the body, and form secondary tumors. But first, an advance team of molecules produced by the primary tumor sets off a series of events that create a network of nurturing blood vessels for arriving primary tumor cells to set up shop.

20 Aug 2013

Study shows complement activation plays an important role in inherited macular degeneration

In a study published on line this week in the journal Human Molecular Genetics, Drs. Donita Garland, Rosario Fernandez-Godino, and Eric Pierce of the Ocular Genomics Institute at the Massachusetts Eye and Ear, Harvard Medical School, along with their colleagues, reported the unexpected finding that in mice genetically engineered to have an inherited form of macular degeneration, turning off the animals' complement system, a part of the immune system, prevented the disease.

20 Aug 2013

KCI launches new app to help physicians become aware of cutting-edge cancer clinical trials

The Barbara Ann Karmanos Cancer Institute (KCI) today announced its new app to help physicians and healthcare professionals become aware of cutting-edge cancer clinical trials, often available only at Karmanos. The KCI Trials App is free and available on the App Store(SM) for the iPhone and iPad.

19 Aug 2013

Tigercat and Velocity Pharmaceutical announce submission of IND application to FDA for VPD-737

Velocity Pharmaceutical Development, LLC ("VPD") and Tigercat Pharma, Inc., ("Tigercat") announced today the submission of an Investigational New Drug (IND) application to the US Food and Drug Administration (FDA) for VPD-737 for the treatment of chronic pruritus.

19 Aug 2013

New type of cancer immunotherapy harnesses body's immune system to attack tumors

By carefully adjusting the function of crucial immune cells, scientists may have developed a completely new type of cancer immunotherapy—harnessing the body's immune system to attack tumors. To accomplish this, they had to thread a needle in immune function, shrinking tumors without triggering unwanted autoimmune responses.

19 Aug 2013

Powerful mechanism helps viruses evade body's immune response

Researchers at the Salk Institute for Biological Studies have discovered a powerful mechanism by which viruses such as influenza, West Nile and Dengue evade the body's immune response and infect humans with these potentially deadly diseases. The findings may provide scientists with an attractive target for novel antiviral therapies.

19 Aug 2013

Study: Gene that controls ageing process linked to cancer

A gene that helps control the ageing process by acting as a cell's internal clock has been linked to cancer by a major new study.

19 Aug 2013

Viewpoints: Medicare's lessons for the health law; Krauthammer says Obama shouldn't try to write his own laws

As a Sept. 30 budget deadline approaches, many in the Republican Party are pushing to repeal the Affordable Care Act, better known as Obamacare. The law's most radical opponents are even threatening to shut down the government by refusing to pass a continuing resolution, which would fund existing government programs at current or slightly adjusted levels.

17 Aug 2013

FDA grants Orphan Drug Designation to Alnylam ALN-AT3 for treatment of hemophilia B

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today that the U.S. Food & Drug Administration (FDA) has granted an Orphan Drug Designation to ALN-AT3 as a therapeutic for the treatment of hemophilia B.

17 Aug 2013

Research roundup: The health of the U.S.; doctors aren't paid to talk; savings from high-deductible plans

Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy. ... From 1990 to 2010, the United States made substantial progress in improving health. Life expectancy at birth and [healthy life expectancy] increased, all-cause death rates at all ages decreased, and age-specific rates of years lived with disability remained stable.

17 Aug 2013

Secondary cancers in melanoma patients treated for BRAF gene mutation require new strategies

Moffitt Cancer Center researchers suggest secondary cancers seen in melanoma patients who are being treated for a BRAF gene mutation may require new strategies, such as enhanced surveillance and combining BRAF-inhibitor therapy with other inhibitors, especially as they become more widely used.

17 Aug 2013

Older heart patients present unique challenges for determining optimal dosages of medications

Older heart patients present unique challenges for determining the optimal dosages of medications, so a new study from researchers at Duke Medicine offers some rare clarity about the use of drugs that are used to treat patients with heart attacks.

17 Aug 2013

Arrays of nanoscale sensors detect flaws in drugs and help improve production

MIT chemical engineers have discovered that arrays of billions of nanoscale sensors have unique properties that could help pharmaceutical companies produce drugs - especially those based on antibodies - more safely and efficiently.

17 Aug 2013

Increased caffeine intake may reduce fatty liver in people with NAFLD

Surprise! Your morning cup of tea or coffee may be doing more than just perking you up before work. An international team of researchers led by Duke-NUS Graduate Medical School (Duke-NUS) and the Duke University School of Medicine suggest that increased caffeine intake may reduce fatty liver in people with non-alcoholic fatty liver disease (NAFLD).

17 Aug 2013

UCSF study shows potential for new treatment strategy for Parkinson’s disease

UC San Francisco scientists working in the lab used a chemical found in an anti-wrinkle cream to prevent the death of nerve cells damaged by mutations that cause an inherited form of Parkinson-s disease.

17 Aug 2013

Chemo before radiotherapy improves efficacy of treatment in testicular cancer patients with low side effects

Giving men with testicular cancer a single dose of chemotherapy alongside radiotherapy could improve the effectiveness of treatment and reduce the risk of long-term side-effects, a new study reports.

17 Aug 2013

DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

A phase I clinical trial showed diffuse, large B-cell lymphomas (DLBCLs) resistant to chemotherapy can be reprogrammed to respond to treatment using the drug azacitidine, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

17 Aug 2013

Prion proteins responsible for Mad cow disease, Creutzfeld-Jakob disease

Mad cow disease and its cousin Creutzfeld-Jakob disease cause fatal spongy changes in brain tissue. Today, we know that these diseases are caused by prions, proteins that are folded incorrectly. A team of German researchers have now been able to follow how the diseased proteins aggregate and "infect" healthy ones on the atomic scale. Their report appears in the journal Angewandte Chemie.

16 Aug 2013

Phase II trial to investigate vaccine therapy combined with Avastin for patients with recurrent GBM

Northwestern Medicine- recently joined a landmark clinical trial to investigate if a vaccine made from a patient's own brain tumor is effective in slowing tumor progression and extending survival.

16 Aug 2013

Mo. lawmaker readies challenge to state coverage for sterilization, contraceptives

A lawmaker in Missouri prepares to challenge the state government's insurance coverage that includes sterilization and contraceptives. In the meantime, a group prepares to appeal a ruling upholding the health law's contraception coverage mandate to the Supreme Court.

16 Aug 2013

Drugs News and Research

Advance team of molecules produced by primary tumor is responsible for lung cancer metastasis

Study shows complement activation plays an important role in inherited macular degeneration

KCI launches new app to help physicians become aware of cutting-edge cancer clinical trials

Tigercat and Velocity Pharmaceutical announce submission of IND application to FDA for VPD-737

New type of cancer immunotherapy harnesses body's immune system to attack tumors

Powerful mechanism helps viruses evade body's immune response

Study: Gene that controls ageing process linked to cancer

Viewpoints: Medicare's lessons for the health law; Krauthammer says Obama shouldn't try to write his own laws

FDA grants Orphan Drug Designation to Alnylam ALN-AT3 for treatment of hemophilia B

Research roundup: The health of the U.S.; doctors aren't paid to talk; savings from high-deductible plans

Secondary cancers in melanoma patients treated for BRAF gene mutation require new strategies

Older heart patients present unique challenges for determining optimal dosages of medications

Arrays of nanoscale sensors detect flaws in drugs and help improve production

Increased caffeine intake may reduce fatty liver in people with NAFLD

UCSF study shows potential for new treatment strategy for Parkinson’s disease

Chemo before radiotherapy improves efficacy of treatment in testicular cancer patients with low side effects

DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

Prion proteins responsible for Mad cow disease, Creutzfeld-Jakob disease

Phase II trial to investigate vaccine therapy combined with Avastin for patients with recurrent GBM

Mo. lawmaker readies challenge to state coverage for sterilization, contraceptives

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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