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Individual hydroxymethylcytosine molecules in DNA detected by new method involving chemical modification and nanopore analysis

Changes in the bases that make up DNA act as markers, telling a cell which genes it should read and which it shouldn’t. In the journal Angewandte Chemie, a British team has now introduced a new method that makes it possible to enrich the rare gene segments that contain the modified base hydroxymethylcytosine and to identify individual hydroxymethylcytosine molecules in DNA. Such modifications are associated with autoimmune diseases and cancer.

24 Apr 2013

Promising development for women with triple-negative breast cancer

Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center team has shown how to exploit tamoxifen's secondary activities so that it might work on more aggressive breast cancer.

24 Apr 2013

Research maps risk factors for transmission of animal brucellosis, BTB to humans

A new study at the Institute of Tropical Medicine in Antwerp analyses the impact of animal brucellosis and bovine tuberculosis on animals and people in urban, peri-urban and rural Niger.

24 Apr 2013

Study identifies malaria parasite protein as potential new target for drug treatment to prevent malaria

Scientists have discovered how a protein within the malaria parasite is essential to its survival as it develops inside a mosquito. They believe their findings identify this protein as a potential new target for drug treatments to prevent malaria being passed to humans.

24 Apr 2013

Researchers studying lipids to learn more about normal, abnormal biology

When you have your cholesterol checked, the doctor typically gives you levels of three fats found in the blood: LDL, HDL and triglycerides. But did you know your body contains thousands of other types of fats, or lipids?

24 Apr 2013

Investigational treatment for ALS passes early phase clinical trial for safety

An investigational treatment for an inherited form of Lou Gehrig's disease has passed an early phase clinical trial for safety, researchers at Washington University School of Medicine in St. Louis and Massachusetts General Hospital report.

24 Apr 2013

Isis Pharmaceuticals starts ISIS-SMNRx Phase 2 study in infants with SMA

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 2 study of ISIS-SMNRx in infants with spinal muscular atrophy. SMA is a severe and rare genetic neuromuscular disease characterized by muscle atrophy and weakness and is the most common genetic cause of infant mortality.

24 Apr 2013

Researchers uncover potential new way to fight obesity-related illness

A potential new way to fight obesity-related illness has been uncovered, thanks to serendipitous research led by investigators at the Case Western Reserve University School of Medicine.

24 Apr 2013

Whole eggs can be part of heart-healthy diet, say researchers

This week at Experimental Biology 2013, scientists from around the world are gathering to share research on a variety of topics, including nutrition and health. Given the growing global burden of chronic disease, there is particular interest in the important role of diet and nutrition in overall health.

24 Apr 2013

Rheumatoid arthritis diagnosis: an interview with Dr. Stan Naides, Medical Director, Quest Diagnostics

Rheumatoid arthritis (RA) is an autoimmune disorder that can cause debilitating joint damage. In cases of RA, the immune system attacks the body’s own tissues, especially the membranes that line the joints. As a result, fluid builds up in the joints, causing pain and systemic inflammation, leading to joint destruction if untreated.

From Quest Diagnostics 23 Apr 2013

Study: Stressful situations at work can have negative impact on cardiovascular system and metabolism

Stressful situations at work can have a negative impact on the cardiovascular system and the metabolism. Stress, which is transmitted by direct and indirect signaling pathways, leads to an inflammatory response in the body, which can trigger cardiovascular diseases, amongst others.

23 Apr 2013

Study suggests lung cancer patients with HER2 mutations may benefit from anti-HER2 drugs

New results from a retrospective study conducted in Europe suggest that anti-HER2 treatments, like the widely used breast cancer agent trastuzumab (Herceptin), have anti-cancer effects in a small subset of patients with advanced non-small cell lung cancer (NSCLC) harboring specific HER2 protein mutations.

23 Apr 2013

Individual cancer cells in blood stream are responsible for metastases in breast cancer patients

Individual cancer cells that break away from the original tumor and circulate through the blood stream are considered responsible for the development of metastases. These dreaded secondary tumors are the main cause of cancer-related deaths.

23 Apr 2013

Animal models of Huntington's disease allow better insights into disease's genetics

Scientific progress in Huntington's disease (HD) relies upon the availability of appropriate animal models that enable insights into the disease's genetics and/or pathophysiology.

23 Apr 2013

Review summarises current data on markers for pancreatic cancer

A team of researchers of the UPV/EHU together with researchers from the Hospital Clínico of Barcelona have produced a bibliographical review that summarises the data currently existing on the markers for pancreatic cancer, and have published it in the specialised journal Clinica Chimica Acta.

23 Apr 2013

Researchers find deficiency in anti-tumor protein can delay DNA repair after radiation treatment

Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment. They suggest that this is because p53 regulates the expression of two enzymes (JMJD2b and SUV39H1) that control the folding of DNA.

23 Apr 2013

Experimental drug can reduce breast-cancer aggressiveness, restore drug-sensitivity

A new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) suggests that an unusual experimental drug can reduce breast-cancer aggressiveness, reverse resistance to the drug fulvestrant and perhaps improve the effectiveness of other breast-cancer drugs.

23 Apr 2013

Exposure to chemical pesticide has impacts that span multiple generations, say researchers

North Carolina State University researchers studying aquatic organisms called Daphnia have found that exposure to a chemical pesticide has impacts that span multiple generations - causing the so-called "water fleas" to produce more male offspring, and causing reproductive problems in female offspring.

23 Apr 2013

TSRI scientists find way to directly turn bone marrow stem cells into brain cells

In a serendipitous discovery, scientists at The Scripps Research Institute have found a way to turn bone marrow stem cells directly into brain cells.

23 Apr 2013

Senesco completes cohort 2 in Phase 1b/2a clinical study of SNS01-T

Senesco Technologies, Inc. reported today that it has completed cohort 2 in its Phase 1b/2a clinical study of SNS01-T.

23 Apr 2013

Protein C News and Research

Individual hydroxymethylcytosine molecules in DNA detected by new method involving chemical modification and nanopore analysis

Promising development for women with triple-negative breast cancer

Research maps risk factors for transmission of animal brucellosis, BTB to humans

Study identifies malaria parasite protein as potential new target for drug treatment to prevent malaria

Researchers studying lipids to learn more about normal, abnormal biology

Investigational treatment for ALS passes early phase clinical trial for safety

Isis Pharmaceuticals starts ISIS-SMNRx Phase 2 study in infants with SMA

Researchers uncover potential new way to fight obesity-related illness

Whole eggs can be part of heart-healthy diet, say researchers

Rheumatoid arthritis diagnosis: an interview with Dr. Stan Naides, Medical Director, Quest Diagnostics

Study: Stressful situations at work can have negative impact on cardiovascular system and metabolism

Study suggests lung cancer patients with HER2 mutations may benefit from anti-HER2 drugs

Individual cancer cells in blood stream are responsible for metastases in breast cancer patients

Animal models of Huntington's disease allow better insights into disease's genetics

Review summarises current data on markers for pancreatic cancer

Researchers find deficiency in anti-tumor protein can delay DNA repair after radiation treatment

Experimental drug can reduce breast-cancer aggressiveness, restore drug-sensitivity

Exposure to chemical pesticide has impacts that span multiple generations, say researchers

TSRI scientists find way to directly turn bone marrow stem cells into brain cells

Senesco completes cohort 2 in Phase 1b/2a clinical study of SNS01-T

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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