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Novel approach for imaging immune cell movements identifies initial steps in inflammatory arthritis

Using a novel approach for imaging the movement of immune cells in living animals, researchers from the Massachusetts General Hospital Center for Immunology and Inflammatory Diseases have identified what appear to be the initial steps leading to joint inflammation in a model of inflammatory arthritis.

20 Jan 2017

Scientists identify how early responses of immune system can affect development of EBOV disease

A new mouse model of early Ebola virus infection has shown National Institutes of Health (NIH) scientists and colleagues how early responses of the immune system can affect development of EBOV disease.

18 Jan 2017

Analgesic effects of opioids can be mediated via immune cells

Opioids are the most powerful painkillers. Researchers at the Charité - Universitätsmedizin Berlin have now found that the analgesic effects of opioids are not exclusively mediated by opioid receptors in the brain, but can also be mediated via the activation of receptors in immune cells.

17 Jan 2017

Functional deficits caused by mini-strokes can last longer than previously thought

Evidence overwhelmingly supports a link between cognitive decline and cerebrovascular diseases such as atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy. Not only do individuals with cerebrovascular diseases have a much higher incidence of cortical microinfarcts (mini-strokes), but post-mortem histological and in vivo radiological studies also find that the burden of microinfarcts is significantly greater among people with vascular cognitive impairment and dementia (VCID) than in age-matched, non-demented individuals.

16 Jan 2017

New antibody design may pave way for treating diseases affecting the brain

Immunotherapy has proven to be effective against many serious diseases. But to treat diseases in the brain, the antibodies must first get past the obstacle of the blood-brain barrier.

16 Jan 2017

Study finds that T cells play important role in control of Zika infections

The worst of the global Zika virus outbreak may be over but many key questions remain, such as why the virus persists in certain tissues after the systemic infection has cleared; how does the immune system counteract the virus and protect against reinfection; what determines the likelihood of long-term complications?

12 Jan 2017

S. pneumoniae uses hosts' immune defenses to spread infection, study reveals

The bacteria that cause most cases of pneumonia worldwide secrete a toxin that helps them jump from one body to the next - with help from the hosts' immune defenses. This is the finding of a study led by researchers from NYU Langone Medical Center and published online January 11 in Cell Host & Microbe.

12 Jan 2017

Chronic consumption of western diet leads to overeating and obesity, new research shows

More than two in three adults in the United States are considered overweight or obese, with substantial biomedical and clinical evidence suggesting that chronic overconsumption of a "western diet" - foods consisting high levels of sugars and fats - is a major cause of this epidemic.

12 Jan 2017

New research paves way for better strategies to diagnose and manage vascular graft infections

A rising prevalence of cardiovascular disease has generated substantial growth in the use of medical implants, such as vascular grafts.

11 Jan 2017

Mayo Clinic scientists identify key molecule that helps protect the central nervous system against sepsis

No effective therapy exists today for sepsis, an inflammatory storm that afflicts about 3 million Americans a year - killing up to half.

10 Jan 2017

Researchers create bone-implant interaction mouse model to assess tissue response to biomaterials

To understand the molecular mechanisms involved in the interaction of bone with orthopedic implants comprised of novel biomaterials, researchers have made a mouse model in which they can assess early tissue responses to surfaces such as bioactive glass.

6 Jan 2017

Experimental treatment approach reverses cognitive decline and neuropathology in AD mouse model

Treatment with an inhibitor of 12/15-lipoxygenase, an enzyme elevated in patients with Alzheimer's disease (AD), reverses cognitive decline and neuropathology in an AD mouse model, reports a new study in Biological Psychiatry.

5 Jan 2017

Researchers uncover two factors that play crucial role in chronic autoimmune disorders

Researchers from Schepens Eye Research Institute of Massachusetts Eye and Ear have uncovered two factors responsible for the chronic, lifelong nature of autoimmune disorders, which tend to "flare up" intermittently in affected patients.

4 Jan 2017

Natural antioxidant can protect offspring of obese mice from NAFLD, study shows

A common antioxidant found in human breast milk and foods like kiwi fruit can protect against nonalcoholic fatty liver disease in the offspring of obese mice, according to researchers at the University of Colorado Anschutz Medical Campus.

4 Jan 2017

Powerful version of anti-inflammatory molecule may help protect vision in diabetic retinopathy

A more powerful version of an anti-inflammatory molecule already circulating in our blood may help protect our vision in the face of diabetes.

3 Jan 2017

Study shows new role of zinc in optic nerve injury

For more than two decades, researchers have tried to regenerate the injured optic nerve using different growth factors and/or agents that overcome natural growth inhibition.

3 Jan 2017

New active pharmaceutical ingredient may help against severe forms of testicular cancer

A new active pharmaceutical ingredient may help against severe forms of testicular cancer, which only respond inadequately to other therapies.

30 Dec 2016

Scientists identify sugar molecule that reduces inflammatory response and COPD progression

Using a mouse model, scientists from the RIKEN-Max Planck Joint Research Center for Systems Chemical Biology and a number of other institutes have identified a sugar molecule that reduced the inflammatory response and progress of emphysema, a common component of chronic obstructive pulmonary disease (COPD).

27 Dec 2016

Potential drug could become first effective treatment option for Prader-Willi syndrome

Duke Health researchers have identified a drug-like small molecule that, in animal experiments, appears to be an effective treatment for a genetic disorder called Prader-Willi syndrome.

27 Dec 2016

Experimental drug improves survival, growth outcomes in mouse model of Prader-Willi syndrome

Drugs capable of activating silenced genes improve survival and growth outcomes in a mouse model of Prader-Willi syndrome, a rare and incurable childhood disease, according to a study funded by the National Institutes of Health.

27 Dec 2016

Mouse Model News and Research

Novel approach for imaging immune cell movements identifies initial steps in inflammatory arthritis

Scientists identify how early responses of immune system can affect development of EBOV disease

Analgesic effects of opioids can be mediated via immune cells

Functional deficits caused by mini-strokes can last longer than previously thought

New antibody design may pave way for treating diseases affecting the brain

Study finds that T cells play important role in control of Zika infections

S. pneumoniae uses hosts' immune defenses to spread infection, study reveals

Chronic consumption of western diet leads to overeating and obesity, new research shows

New research paves way for better strategies to diagnose and manage vascular graft infections

Mayo Clinic scientists identify key molecule that helps protect the central nervous system against sepsis

Researchers create bone-implant interaction mouse model to assess tissue response to biomaterials

Experimental treatment approach reverses cognitive decline and neuropathology in AD mouse model

Researchers uncover two factors that play crucial role in chronic autoimmune disorders

Natural antioxidant can protect offspring of obese mice from NAFLD, study shows

Powerful version of anti-inflammatory molecule may help protect vision in diabetic retinopathy

Study shows new role of zinc in optic nerve injury

New active pharmaceutical ingredient may help against severe forms of testicular cancer

Scientists identify sugar molecule that reduces inflammatory response and COPD progression

Potential drug could become first effective treatment option for Prader-Willi syndrome

Experimental drug improves survival, growth outcomes in mouse model of Prader-Willi syndrome

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