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Research shows pNaKtide can attenuate development of NAFLD and atherosclerosis

Building on their recent research focusing on a peptide, pNaKtide, designed to block the oxidant amplifying function of the cellular sodium-potassium pump, researchers at Marshall University Joan C. Edwards School of Medicine have successfully demonstrated that pNaKtide, can attenuate the development of experimental nonalcoholic fatty liver disease (NAFLD) and atherosclerosis.

15 Mar 2017

Targeting cancer stem cells may be effective way to prevent spread of squamous cell carcinoma

Targeting cancer stem cells may be a more effective way to overcome cancer resistance and prevent the spread of squamous cell carcinoma — the most common head and neck cancer and the second-most common skin cancer, according to a new study by cancer researchers at the UCLA School of Dentistry.

10 Mar 2017

Combination therapy that targets immune-busting cells effective in treating advanced prostate cancer

Advanced prostate cancer resistant to castration therapy appears to respond well to a combination of immune checkpoint blockades and treatments that target certain immune-busting cells commonly associated with poor patient prognosis and therapy resistance.

10 Mar 2017

Drug could activate innate anti-tumor immunity to eradicate aggressive prostate cancer in mice

Cabozantinib, a drug already used to treat patients with certain types of thyroid or kidney cancer, was able to eradicate invasive prostate cancers in mice by causing tumor cells to secrete factors that entice neutrophils - the first-responders of the immune system - to infiltrate the tumor, where they triggered an immune response that led to tumor clearance.

9 Mar 2017

Study reveals promising new strategy to attack deadly pediatric brain tumor

Researchers from Northwestern Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago have revealed new insight into how the most deadly pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG), may develop.

7 Mar 2017

TSRI scientists discover how key protein establishes proper vision

Scientists from the Florida campus of The Scripps Research Institute have discovered how a protein called α2δ4 establishes proper vision.

6 Mar 2017

Blocking protein found on surface of ovarian cancer cells could prevent metastasis, research suggests

Blocking a protein found on the surface of ovarian cancer cells could prevent or reduce the spread of the disease to other organs, according to new research at the University of Illinois at Chicago.

3 Mar 2017

Immune-stimulating chemical found in tumors may help stop cancer growth

A chemical found in tumors may help stop tumor growth, according to a new study.

2 Mar 2017

Researchers probe potential link between gut microbiota and poor artery health

Scientific evidence that the assortment of gut microbes in humans influences different and critical aspects of health is piling up: Researchers think our microbes may influence obesity, anxiety, depression, autism, cancer and gastrointestinal diseases.

1 Mar 2017

Highly prevalent gene variants in African Americans contribute to kidney disease

African Americans have a heightened risk of developing chronic and end-stage kidney disease. This association has been attributed to two common genetic variants - named G1 and G2 -- in APOL1, a gene that codes for a human-specific protein.

1 Mar 2017

Duke researchers discover potential cause for ALS syndromes using mouse models

A team of researchers at Duke University Medical Center led by Dr. Paulo Ferreira and whose work was supported by the National Institutes of Health has found that derailing the transport of certain receptors that carry cargoes from and to the nucleus of motor neurons causes motor neuron disease in mice.

1 Mar 2017

Danish researchers get closer to finding treatment for malignant cerebral tumour in children

DIPG (Diffuse Intrinsic Pontine Glioma) is a rare malignant cerebral tumour in children. It has only a 1% 5-year survival rate, amongst other things because it is not possible to operate because the tumour is located in the brain stem.

28 Feb 2017

Activated T-cells promote heart failure after heart attack

Chronic inflammation after a heart attack can promote heart failure and death. University of Alabama at Birmingham researchers have now shown that activated T-cells — part of the immune system's inflammatory response — are both necessary and sufficient to produce such heart failure.

28 Feb 2017

KRAS ‘imbalances’ that emerge over time may influence cancer treatment response

Choosing among cancer treatments increasingly involves determining whether tumor cells harbor specific, mutated "oncogenes" that drive abnormal growth and that may also be especially vulnerable or resistant to particular drugs.

28 Feb 2017

Scientists find link between p53 gene in African American women and breast cancer risk

Scientists at The Wistar Institute in collaboration with Roswell Park Cancer Institute found a significant association between a rare genetic variant of the p53 gene present in African American women and their risk of developing breast cancer in premenopausal age. The study was published online by the journal NPJ Breast Cancer.

27 Feb 2017

New research offers insights into how differences arise in common illnesses

As much as we try to avoid it, we are constantly sharing germs with those around us. But even when two people have the same infection, the resulting illnesses can be dramatically different--mild for one person, severe or even life-threatening for the other.

24 Feb 2017

Study reveals mechanisms behind Zika transmission to fetus and adverse perinatal outcomes

Johns Hopkins researchers say that in early pregnancy in mice with complete immune systems, Zika virus can cross the placenta -- intended to protect the developing fetus -- and appears to lead to a high percentage of miscarriages and to babies born with thin brain tissue and inflammation in brain cells.

23 Feb 2017

Mouse model shows how chronic demyelination may cause seizures in MS patients

Multiple sclerosis is an autoimmune disease of the central nervous system that affects nearly 2.3 million people worldwide.

22 Feb 2017

Treating multiple myeloma with rabbit virus eliminates majority of malignant cells, study shows

Treating multiple myeloma (MM) with myxoma virus (MYXV) eliminated a majority of malignant cells in preclinical studies, report investigators at the Medical University of South Carolina and elsewhere in an article published online on December 7, 2016 by Molecular Therapy -- Oncolytics.

22 Feb 2017

Researchers develop novel in vivo model for studying pancreatic cancer

Researchers at Okayama University report in the December 2016 issue of the American Journal of Cancer Research a novel in vivo model for the study of pancreatic ductal adenocarcinoma (PDAC) tumors.

21 Feb 2017

Mouse Model News and Research

Research shows pNaKtide can attenuate development of NAFLD and atherosclerosis

Targeting cancer stem cells may be effective way to prevent spread of squamous cell carcinoma

Combination therapy that targets immune-busting cells effective in treating advanced prostate cancer

Drug could activate innate anti-tumor immunity to eradicate aggressive prostate cancer in mice

Study reveals promising new strategy to attack deadly pediatric brain tumor

TSRI scientists discover how key protein establishes proper vision

Blocking protein found on surface of ovarian cancer cells could prevent metastasis, research suggests

Immune-stimulating chemical found in tumors may help stop cancer growth

Researchers probe potential link between gut microbiota and poor artery health

Highly prevalent gene variants in African Americans contribute to kidney disease

Duke researchers discover potential cause for ALS syndromes using mouse models

Danish researchers get closer to finding treatment for malignant cerebral tumour in children

Activated T-cells promote heart failure after heart attack

KRAS ‘imbalances’ that emerge over time may influence cancer treatment response

Scientists find link between p53 gene in African American women and breast cancer risk

New research offers insights into how differences arise in common illnesses

Study reveals mechanisms behind Zika transmission to fetus and adverse perinatal outcomes

Mouse model shows how chronic demyelination may cause seizures in MS patients

Treating multiple myeloma with rabbit virus eliminates majority of malignant cells, study shows

Researchers develop novel in vivo model for studying pancreatic cancer

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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