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Experimental gene therapy may improve health outcomes for patients with some forms of blood disorders

New research adds to a growing body of evidence that gene therapy, an experimental technique that involves correcting or replacing a person's mutated or malfunctioning genes, may improve health outcomes for patients with inherited bleeding and immune disorders as well as some forms of blood cancer.

7 Dec 2015

Anthracycline-based breast cancer chemotherapy linked to neurotoxicity

Breast cancer patients treated with anthracycline-based chemotherapy regimens may be at greater risk of neurocognitive problems than those given nonanthracycline regimens, indicate findings.

4 Dec 2015

Blood gas analyser for use in winter flu isolation beds

Sphere Medical, an innovator company in critical care monitoring and diagnostics equipment, announces that at the Intensive Care Society State of the Art Meeting 2015, it will be discussing the potential application of its Proxima patient-dedicated blood gas analyser with isolation beds during winter flu outbreaks.

3 Dec 2015

Small-vessel disease has uncertain impact on large-vessel stenosis outcomes

Research shows that small-vessel disease is common among patients with intracranial arterial stenosis, but that its effect on stroke risk cannot be separated from the effect of associated risk factors.

2 Dec 2015

Potential for chemotherapy-free standard of care in advanced mantle cell lymphoma

The combination of ibrutinib and rituximab shows activity in patients with relapsed or refractory mantle cell lymphoma, suggests research published in The Lancet Oncology.

2 Dec 2015

Novel class of antimicrobials could be effective in fighting drug-resistant MRSA infection

A novel class of antimicrobials that inhibits the function of a key disease-causing component of bacteria could be effective in fighting methicillin-resistant Staphylococcus aureus (MRSA), one of the major drug-resistant bacterial pathogens, according to researchers at Georgia State University.

1 Dec 2015

$Reduced bone mass puts critically ill patients at greater risk for fractures$

Reduced bone mass puts critically ill patients at greater risk for fractures

One year after being hospitalized in intensive care, patients have reduced bone mass that puts them at greater risk for fractures, according to a new study published online ahead of print in the American Journal of Respiratory and Critical Care Medicine.

1 Dec 2015

TGen, Barrow researchers identify genetic risk factors linked to stress-induced cardiomyopathy

Researchers at the Translational Genomics Research Institute and Barrow Neurological Institute have for the first time identified genetic risk factors that are linked to stress-induced cardiomyopathy (SIC), a rare type of heart disease.

1 Dec 2015

Low levels of BRCA1 protein in the brain linked to dementia

Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer's disease. The results, published in Nature Communications, suggest that low levels of BRCA1 protein in the brain may contribute to dementia.

1 Dec 2015

Weight loss can slow degeneration of knee cartilage in obese people

Obese people who lose a substantial amount of weight can significantly slow the degeneration of their knee cartilage, according to a new MRI study presented today at the annual meeting of the Radiological Society of North America.

30 Nov 2015

Prehospital combination therapy disappoints in status epilepticus

Adding levetiracetam to prehospital treatment with clonazepam does not improve control of generalised convulsive status epilepticus, shows a randomised phase III trial.

27 Nov 2015

Epilepsy common but variable in mitochondrial disease patients

Around a quarter of patients with mitochondrial diseases have seizures, but these do not appear to increase their risk of dying, report researchers.

27 Nov 2015

Second-line bosutinib offers ‘durable’ response for chronic phase CML patients

Four-year results for an ongoing study of second-line bosutinib indicate that the tyrosine kinase inhibitor offers long-term efficacy with manageable side effects for patients with chronic phase chronic myeloid leukaemia.

27 Nov 2015

Rare variants linked with Parkinson’s disease

Researchers using exome sequencing in families with Parkinson’s disease have identified two genes that could be associated with the condition.

27 Nov 2015

Discovery opens up new avenue for research on potential treatments for Alzheimer's disease

A team of researchers led by UNSW Australia scientists has discovered how connections between brain cells are destroyed in the early stages of Alzheimer's disease - work that opens up a new avenue for research on possible treatments for the degenerative brain condition.

27 Nov 2015

New study reveals effect of cannabis potency on brain structure

Smoking high potency 'skunk-like' cannabis can damage a crucial part of the brain responsible for communication between the two brain hemispheres, according to a new study by scientists from King's College London and Sapienza University of Rome.

27 Nov 2015

Obese children with NAFLD not meeting recommended physical activity levels

In a new study published today in the journal Nutrients, research from the University of Surrey and the Children's Liver Disease Foundation has found that both obese children and those with Non-Alcoholic Fatty Liver Disease (NAFLD) are not meeting the UK recommendations for a variety of vitamins and minerals.

26 Nov 2015

Researchers use magic-angle-spinning NMR to unveil structure of CAP-Gly protein

A latticework of tiny tubes called microtubules gives your cells their shape and also acts like a railroad track that essential proteins travel on. But if there is a glitch in the connection between train and track, diseases can occur.

26 Nov 2015

Columbia University data scientists create world's first catalog of therapeutic venom

What doesn't kill you could cure you. A growing interest in the therapeutic value of animal venom has led a pair of Columbia University data scientists to create the first catalog of known animal toxins and their physiological effects on humans.

26 Nov 2015

People with viral infections and identical gene mutations may be prone to hyperinflammatory disorder

A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a study in The Journal of Infectious Diseases.

25 Nov 2015

X linked News and Research

Experimental gene therapy may improve health outcomes for patients with some forms of blood disorders

Anthracycline-based breast cancer chemotherapy linked to neurotoxicity

Blood gas analyser for use in winter flu isolation beds

Small-vessel disease has uncertain impact on large-vessel stenosis outcomes

Potential for chemotherapy-free standard of care in advanced mantle cell lymphoma

Novel class of antimicrobials could be effective in fighting drug-resistant MRSA infection

Reduced bone mass puts critically ill patients at greater risk for fractures

TGen, Barrow researchers identify genetic risk factors linked to stress-induced cardiomyopathy

Low levels of BRCA1 protein in the brain linked to dementia

Weight loss can slow degeneration of knee cartilage in obese people

Prehospital combination therapy disappoints in status epilepticus

Epilepsy common but variable in mitochondrial disease patients

Second-line bosutinib offers ‘durable’ response for chronic phase CML patients

Rare variants linked with Parkinson’s disease

Discovery opens up new avenue for research on potential treatments for Alzheimer's disease

New study reveals effect of cannabis potency on brain structure

Obese children with NAFLD not meeting recommended physical activity levels

Researchers use magic-angle-spinning NMR to unveil structure of CAP-Gly protein

Columbia University data scientists create world's first catalog of therapeutic venom

People with viral infections and identical gene mutations may be prone to hyperinflammatory disorder

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