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Researchers explain how gut bacteria can inactivate cardiac drugs

For decades, doctors have understood that microbes in the human gut can influence how certain drugs work in the body - by either activating or inactivating specific compounds, but questions have long remained about exactly how the process works.

26 Jul 2013

Researchers uncover way to stop cancer cells using HIF-1 gene through synthetic biology approach

Scientists have discovered a new molecule that prevents cancer cells from responding and surviving when starved of oxygen and which could be developed into new treatments for the disease, according to new research published in the Journal of the American Chemical Society today (Friday).

26 Jul 2013

Silk implants placed in brain of animals may help stop progression of epilepsy

Silk has walked straight off the runway and into the lab. According to a new study published in the Journal of Clinical Investigation, silk implants placed in the brain of laboratory animals and designed to release a specific chemical, adenosine, may help stop the progression of epilepsy.

26 Jul 2013

Research finds potential long-term effects of marijuana use in adolescence

Regular marijuana use in adolescence, but not adulthood, may permanently impair brain function and cognition, and may increase the risk of developing serious psychiatric disorders such as schizophrenia, according to a recent study from the University of Maryland School of Medicine.

25 Jul 2013

Discovery of pressure-driven infection mechanism opens door to new treatments for viral infections

The virus that causes those painful lip blisters known as cold sores has an internal pressure eight times higher than a car tire, and uses it to literally blast its infectious DNA into human cells, scientists are reporting in a new study.

25 Jul 2013

Combination treatment can reduce hepatitis C infection in people who inject drugs

The burden of liver disease could be dramatically reduced by scaling up the combination of interventions for hepatitis C infection among people who inject drugs according to University of Bristol researchers. The findings, published today [24 July], form part of new global recommendations on treating the virus.

25 Jul 2013

Stem cell-based epilepsy approach may help in search for better medicines to treat seizure disorders

A new stem cell-based approach to studying epilepsy has yielded a surprising discovery about what causes one form of the disease, and may help in the search for better medicines to treat all kinds of seizure disorders.

25 Jul 2013

Combination of 6 comprehensive measures to prevent spread of hepatitis C

UC San Francisco researchers are recommending a combination of six comprehensive measures to prevent the spread of hepatitis C, in an effort to address the more than 31,000 young people they estimate may be newly infected with the virus each year in the United States due to injection-drug use.

25 Jul 2013

Enzyme in airway lining cells could hold key for asthma sufferers

An enzyme known for its role in heart disease may well be a promising target to treat asthma. Researchers from the University of Iowa have found that the enzyme, called CaMKII, is linked to the harmful effects of oxidation in the respiratory tract, triggering asthmatic symptoms.

25 Jul 2013

Researchers identify key molecular pathways that lead to late-onset Alzheimer's disease

Key molecular pathways that ultimately lead to late-onset Alzheimer's disease, the most common form of the disorder, have been identified by researchers at Columbia University Medical Center (CUMC).

25 Jul 2013

Scientists identify new genetic mutations that can cause pulmonary arterial hypertension

Columbia University Medical Center (CUMC) scientists have identified new genetic mutations that can cause pulmonary arterial hypertension (PAH), a rare fatal disease characterized by high blood pressure in the lungs.

25 Jul 2013

Stopping cholesterol drugs may increase risk of Parkinson's disease

People who stop taking cholesterol drugs may be at an increased risk for developing Parkinson's disease, according to research that appears in the July 24, 2013, online issue of Neurology, the medical journal of the American Academy of Neurology.

25 Jul 2013

New clinic focuses on men with fast-growing prostate cancer

While every year about 30,000 men die of prostate cancer in the United States, the most common cause of death in men with prostate cancer is heart disease. That's because not all prostate cancers are the same. Some are slow-growing while others are very aggressive.

25 Jul 2013

Verastem's defactinib gets FDA orphan drug designation for treatment of mesothelioma

Verastem, Inc., focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced that lead cancer stem cell inhibitor, VS-6063 (defactinib), has received orphan drug designation from the U.S. Food and Drug Administration for use in the treatment of mesothelioma, a rare form of lung cancer.

24 Jul 2013

FDB High Risk Medication Module released

First Databank, a leading provider of clinical drug knowledge that improves medication-related decisions and patient outcomes, today announced the release of the FDB High Risk Medication Module.

24 Jul 2013

Cambridge Consultants help Clinigen Group to breathe new life into old drugs

Innovative product development and technology consultancy firm Cambridge Consultants has collaborated with Clinigen Group to create a new way of identifying fresh market applications for drugs nearing the end of their product lifecycle.

From Clinigen Group 24 Jul 2013

UL researcher receives €1.5 million to develop innovative treatments for bone-loss diseases

UL researcher, Dr David Hoey was announced as one of the recipients of the highly prestigious European Research Council (ERC) starting grants. Dr Hoey has been awarded €1.5 million to pursue cutting-edge fundamental research into developing innovative treatments for bone-loss diseases such as osteoporosis. Every 30 seconds a person suffers an osteoporosis-related hip fracture in the EU.

24 Jul 2013

Child cancer survival: an interview with Prof Kathy Pritchard-Jones, University College London

Back in the early 1960s, just before chemotherapy really started to be used, only about 30% of children survived cancer. That was mainly because they had cancers that were amenable to surgery.

24 Jul 2013

New procedures to improve quality and usefulness of preclinical efficacy studies

Only 11% of drugs that enter clinical trials in humans are ultimately found safe and effective enough to receive regulatory approval.

24 Jul 2013

Researchers discover mechanism that prevents immune system from spinning out of control

A team led by a University of Arizona researcher has discovered a previously unknown mechanism that prevents the immune system from going into overdrive, shedding light not only on how our body controls its response to pathogens but on conditions such as autoimmune diseases, allergies and chronic inflammation as well.

24 Jul 2013

Drugs News and Research

Researchers explain how gut bacteria can inactivate cardiac drugs

Researchers uncover way to stop cancer cells using HIF-1 gene through synthetic biology approach

Silk implants placed in brain of animals may help stop progression of epilepsy

Research finds potential long-term effects of marijuana use in adolescence

Discovery of pressure-driven infection mechanism opens door to new treatments for viral infections

Combination treatment can reduce hepatitis C infection in people who inject drugs

Stem cell-based epilepsy approach may help in search for better medicines to treat seizure disorders

Combination of 6 comprehensive measures to prevent spread of hepatitis C

Enzyme in airway lining cells could hold key for asthma sufferers

Researchers identify key molecular pathways that lead to late-onset Alzheimer's disease

Scientists identify new genetic mutations that can cause pulmonary arterial hypertension

Stopping cholesterol drugs may increase risk of Parkinson's disease

New clinic focuses on men with fast-growing prostate cancer

Verastem's defactinib gets FDA orphan drug designation for treatment of mesothelioma

FDB High Risk Medication Module released

Cambridge Consultants help Clinigen Group to breathe new life into old drugs

UL researcher receives €1.5 million to develop innovative treatments for bone-loss diseases

Child cancer survival: an interview with Prof Kathy Pritchard-Jones, University College London

New procedures to improve quality and usefulness of preclinical efficacy studies

Researchers discover mechanism that prevents immune system from spinning out of control

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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