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Combination of three drugs extends the survival of patients with metastatic, hormone-sensitive prostate cancer

Results from an international, randomized, double-blind, placebo-controlled, phase 3 clinical trial indicate that adding the androgen-receptor inhibitor darolutamide to androgen-deprivation therapy and chemotherapy prolongs the survival of men with metastatic, hormone-sensitive prostate cancer, a disease that is fatal in most cases.

18 Feb 2022

Novel approach pinpoints genetic variants involved in congenital heart disease

Nearly 1 percent of all children are born with congenital heart disease - a range of potentially life-threatening problems with the structure and function of their hearts. For most children, the precise causes of these frightening defects are unknown.

18 Feb 2022

International Aspirin Foundation publishes a report on the work of highly commended investigators

The International Aspirin Foundation has published a report of the Winner and Highly Commended awardees, present at the prestigious Emerging Aspirin Investigator Award Ceremony.

18 Feb 2022

Intermediate size nanoparticles may be effective at stopping internal bleeding

Traumatic injuries are the leading cause of death in the U.S. among people 45 and under, and such injuries account for more than 3 million deaths per year worldwide.

17 Feb 2022

Study finds 'substantial decrease' in people's mental wellbeing since the start of the pandemic

People in the UK have experienced a "substantial decrease" in mental wellbeing since the start of the Covid pandemic - according to new research from the University of East Anglia and University of York.

17 Feb 2022

Dual access veno-arterial approach increases mortality rate for babies in respiratory failure put on ECMO

The current trend of using two cannulas to place most newborns in respiratory failure on life-sustaining ECMO, one in the right internal jugular vein and a second in the right common carotid artery, rather than a single cannula in the right internal jugular, increases mortality rates for these babies, investigators report.

17 Feb 2022

Treatment found to be safe, efficacious in improving insomnia and night sweats among midlife women

Hot flashes and night sweats are a common cause of insomnia among peri- and postmenopausal women. Hot flashes, night sweats and insomnia are all linked to reduced quality of life and distress.

17 Feb 2022

Smartphone-based COVID-19 detection system

In this interview, we speak to Professor Michael Mahan about his latest research which aimed to bring low-cost, state-of-the-art diagnostics to resource-limited settings.

17 Feb 2022

Study investigates what causes blood malignancies linked to gene therapy for sickle cell disease

Gene therapy trials for sickle cell disease have been showing great promise, even offering hope of a cure. But in early 2021, the trials ground to a halt after reports of blood malignancies in two people in a trial sponsored by bluebird bio.

16 Feb 2022

Study finds higher mortality rates among African children and adolescents hospitalized with COVID-19

African children and adolescents hospitalized with COVID-19 experience much higher mortality rates than Europeans or North Americans of the same age, according to a recently published study conducted by researchers from the Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM) and the Institute of Human Virology Nigeria (IHVN).

16 Feb 2022

Transformational $104 million gift will help VCU to expand treatment options for liver diseases

Virginia Commonwealth University will radically expand treatment options for liver and liver-related metabolic diseases thanks to a historic, transformational $104 million gift from Richard Todd Stravitz, M.D., and his family's Barbara Brunckhorst Foundation.

15 Feb 2022

Researchers identify a powerful combination of antivirals to treat COVID-19

Researchers at the University of Maryland School of Medicine and University of Pennsylvania Perelman School of Medicine have identified a powerful combination of antivirals to treat COVID-19.

14 Feb 2022

CDC study first to show waning immunity after third dose of mRNA COVID-19 vaccine

A nationwide study from the U.S. Centers for Disease Control and Prevention is the first to show that immunity against severe COVID-19 disease begins to wane 4 months after receipt of the third dose of an mRNA vaccine (Pfizer or Moderna).

12 Feb 2022

Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

MUSC Hollings Cancer Center researcher Sophie Paczesny, M.D., Ph.D., recently received a four-year grant from the National Heart, Lung, and Blood Institute to investigate solutions to help doctors to fight complications after pediatric bone marrow transplantation (BMT).

12 Feb 2022

Sleep apnea during pregnancy linked to the development of hypertension and metabolic syndrome

In a new study published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine, researchers examined whether sleep disordered breathing (primarily obstructive sleep apnea) during pregnancy and in the years after delivery is associated with an increased risk for hypertension and metabolic syndrome.

12 Feb 2022

Challenges in safely deprescribing common anticholinergic drugs

Medications with anticholinergic properties have been consistently associated with a wide range of adverse outcomes for older adults including cognitive impairment, yet these drugs continue to be commonly prescribed for depression, urinary incontinence, irritable bowel syndrome and Parkinson's disease.

11 Feb 2022

Direct oral anti-coagulants less likely to result in major bleeding after rare, fatal stroke

Direct oral anti-coagulant (anti-clotting) (DOAC) medications that target a single clotting factor work just as well to prevent future clots as the older, less-specific medication warfarin.

11 Feb 2022

Alkem signs license agreement with Harvard to develop, commercialize new technology for treating ischemic conditions

Alkem Laboratories Limited, an Indian multinational pharmaceutical company, has signed a license agreement with Harvard University's Office of Technology Development enabling Alkem to develop and commercialize a novel technology that may help meet the dire need for effective treatment of diabetic neuropathy, foot ulcers, peripheral arterial disease (PAD), and other injuries caused by vascular disease.

11 Feb 2022

Molecular treatment works against metastatic cancer that spread to the brain

Mount Sinai researchers conducting clinical trials of a drug targeting a cancer gene found that it increased metastatic cancer patients' survival and was able to work within the brain, according to a study published in Clinical Cancer Research in February.

10 Feb 2022

New rapid, cheaper test could help advance personalized cancer treatment

Using a routine blood sample, investigators have developed an extremely sensitive assay to detect and quantify DNA fragments containing rare genetic mutations in a patient's cancer cells.

10 Feb 2022

Medical School News and Research

Combination of three drugs extends the survival of patients with metastatic, hormone-sensitive prostate cancer

Novel approach pinpoints genetic variants involved in congenital heart disease

International Aspirin Foundation publishes a report on the work of highly commended investigators

Intermediate size nanoparticles may be effective at stopping internal bleeding

Study finds 'substantial decrease' in people's mental wellbeing since the start of the pandemic

Dual access veno-arterial approach increases mortality rate for babies in respiratory failure put on ECMO

Treatment found to be safe, efficacious in improving insomnia and night sweats among midlife women

Smartphone-based COVID-19 detection system

Study investigates what causes blood malignancies linked to gene therapy for sickle cell disease

Study finds higher mortality rates among African children and adolescents hospitalized with COVID-19

Transformational $104 million gift will help VCU to expand treatment options for liver diseases

Researchers identify a powerful combination of antivirals to treat COVID-19

CDC study first to show waning immunity after third dose of mRNA COVID-19 vaccine

Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

Sleep apnea during pregnancy linked to the development of hypertension and metabolic syndrome

Challenges in safely deprescribing common anticholinergic drugs

Direct oral anti-coagulants less likely to result in major bleeding after rare, fatal stroke

Alkem signs license agreement with Harvard to develop, commercialize new technology for treating ischemic conditions

Molecular treatment works against metastatic cancer that spread to the brain

New rapid, cheaper test could help advance personalized cancer treatment

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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