Mouse Model News and Research

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New research provides clues to how antibody treatment led to remission in SIV-infected monkeys

Scientists at the National Institutes of Health have found that the presence of the protein alpha-4 beta-7 integrin on the surface of HIV and its monkey equivalent--simian immunodeficiency virus, or SIV--may help explain why an antibody protected monkeys from SIV in previous experiments.

16 Feb 2017

Salk scientists use mRNA to successfully treat hemophilia B in mice

FedEx, UPS, DHL--when it comes to sending packages, choices abound. But the most important delivery service you may not have heard of mRNA.

16 Feb 2017

Signals from fat cells may aid in diagnostics for metabolic conditions

Fat cells are not simply big blobs of lipid quietly standingby in the body--instead, they send out hormones and other signaling proteins that affect many types of tissues.

15 Feb 2017

Duke Health researchers identify potential new drug target for Huntington's disease

The loss of motor function and mental acuity associated with Huntington's disease might be treatable by restoring a cellular quality control process, which Duke Health researchers have identified as a key factor in the degenerative illness.

13 Feb 2017

New drug offers hope for patients with bladder cancer

A bladder cancer drug discovered and developed at The University of Kansas Cancer Center is set to become its first cancer drug to go from bench to bedside.

10 Feb 2017

Direct radiolabeling of nanographene materials enhances bioimaging accuracy, reduces biases

Positron emission tomography plays a pivotal role for monitoring the distribution and accumulation of radiolabeled nanomaterials in living subjects. The radioactive metals are usually connected to the nanomaterial through an anchor, a so-called chelator, but this chemical binding can be omitted if nanographene is used, as American scientists report in the journal Angewandte Chemie

10 Feb 2017

Study suggests new ways to treat neurological symptoms linked to tuberous sclerosis complex

Boston Children's Hospital researchers have uncovered a new molecular pathway that inhibits the myelination of neurons in the brains of patients with the rare genetic disorder tuberous sclerosis complex.

9 Feb 2017

New therapeutic agent shows potential for treating optic neuritis linked to multiple sclerosis

A new therapeutic agent tested in a mouse model of multiple sclerosis (MS) produced anti-inflammatory activity and prevented loss of cells in the optic nerve, according to a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania, with Pittsburgh-based Noveome Biotherapeutics.

9 Feb 2017

New study uncovers important links between glioblastoma and epileptic seizures

Detecting brain tumors at the earliest possible stage and eliminating them before seizures begin might be possible one day, according to research by scientists at Baylor College of Medicine and Texas Children's Hospital.

7 Feb 2017

Scientists show how immune receptor activated by bacteria contributes to diabetic bladder dysfunction

Bladder dysfunction is a reality for about half of patients with diabetes and now scientists have evidence that an immune system receptor that's more typically activated by bacteria is a major contributor.

7 Feb 2017

Northwestern Medicine scientists discover retinal cell that may cause myopia

Northwestern Medicine scientists have discovered a cell in the retina that may cause myopia when it dysfunctions. The dysfunction may be linked to the amount of time a child spends indoors and away from natural light.

6 Feb 2017

Scientists discover treatment that improves symptoms in mouse model of juvenile Batten disease

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and King's College London have discovered a treatment that improves the neurological symptoms in a mouse model of juvenile Batten disease.

6 Feb 2017

Penn scientists find cytokine as key to fighting and treating viral infection in the lungs

Viral infections that occur in a patient's lungs are a significant cause of hospitalization and death among children and the elderly.

3 Feb 2017

NIH researchers shed light on role of S. epidermidis toxin in bacterial sepsis

Staphylococcus epidermidis bacteria are a significant health concern for hospitalized infants, children and anyone with implanted medical devices.

2 Feb 2017

New study offers insights into how antidepressants work in the brain

When they work, antidepressant medications may take weeks or months to alleviate symptoms of depression.

2 Feb 2017

Glucose deprivation in the brain triggers onset of cognitive decline, research shows

One of the earliest signs of Alzheimer's disease is a decline in glucose levels in the brain. It appears in the early stages of mild cognitive impairment -- before symptoms of memory problems begin to surface.

31 Jan 2017

Study reveals new molecular mechanism vital for associative memory encoding in the hippocampus

A new study, published on the cover of the scientific journal Biological Psychiatry and lead by Dr Carlos Saura from the Institut de Neurociències at the Universitat Autònoma de Barcelona, reveals a new molecular mechanism essential for associative memory encoding in the hippocampus.

31 Jan 2017

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

A handful of FDA-approved drugs exist for treating individuals with alcohol use disorder but they have been largely ineffective at reducing the high rates of relapse. As such, there remains a critical need to identify and develop alternative pharmacological treatment options.

31 Jan 2017

Research findings could lead to effective repair therapies for peripheral nerve damage

Research published today, 30th January 2017 online in the Journal of Cell Biology, has for the first time identified how a bodily protein allows nerves of the peripheral nervous system (PNS) to repair following injury.

30 Jan 2017

Bacterial by-product helps correct gut microbiome imbalance in mouse model of ALS

A bacterial by-product known to be important in maintaining gut health may slow the progression of amyotrophic lateral sclerosis, or ALS - a progressive, neurodegenerative disease.

27 Jan 2017

Mouse Model News and Research

New research provides clues to how antibody treatment led to remission in SIV-infected monkeys

Salk scientists use mRNA to successfully treat hemophilia B in mice

Signals from fat cells may aid in diagnostics for metabolic conditions

Duke Health researchers identify potential new drug target for Huntington's disease

New drug offers hope for patients with bladder cancer

Direct radiolabeling of nanographene materials enhances bioimaging accuracy, reduces biases

Study suggests new ways to treat neurological symptoms linked to tuberous sclerosis complex

New therapeutic agent shows potential for treating optic neuritis linked to multiple sclerosis

New study uncovers important links between glioblastoma and epileptic seizures

Scientists show how immune receptor activated by bacteria contributes to diabetic bladder dysfunction

Northwestern Medicine scientists discover retinal cell that may cause myopia

Scientists discover treatment that improves symptoms in mouse model of juvenile Batten disease

Penn scientists find cytokine as key to fighting and treating viral infection in the lungs

NIH researchers shed light on role of S. epidermidis toxin in bacterial sepsis

New study offers insights into how antidepressants work in the brain

Glucose deprivation in the brain triggers onset of cognitive decline, research shows

Study reveals new molecular mechanism vital for associative memory encoding in the hippocampus

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

Research findings could lead to effective repair therapies for peripheral nerve damage

Bacterial by-product helps correct gut microbiome imbalance in mouse model of ALS

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