Protein C News and Research

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Salty diet may trigger autoimmune disease

Results from two studies published in Nature show that eating a salty diet may trigger the development of autoimmunity.

7 Mar 2013

CALHM1 channel protein releases ATP to make neural taste connections

Saying that the sense of taste is complicated is an understatement, that it is little understood, even more so. Exactly how cells transmit taste information to the brain for three out of the five primary taste types was pretty much a mystery, until now.

7 Mar 2013

Researchers identify role of Merlin in regulating integrity of axons

One in 25,000 people worldwide is affected by neurofibromatosis type 2 (NF2), a condition where the loss of a tumour suppressor called Merlin results in multiple tumours in the brain and nervous system.

7 Mar 2013

Study now tells physicians that dystonia can occur in African-American patients

A pair of studies tells the tale of how a neuroscientist at Mayo Clinic in Florida helped to discover the first African-American family to have inherited the rare movement disorder dystonia, which causes repetitive muscle contractions and twisting, resulting in abnormal posture.

7 Mar 2013

‘New Frontiers in Neurodegenerative Disease Research’ symposium to be held from Feb. 4-7

At the Keystone Symposium "New Frontiers in Neurodegenerative Disease Research," held 4-7 February in Santa Fe, New Mexico, researchers explored the processes that lead to a variety of diseases, including Alzheimer's and Lou Gehrig's disease (amyotrophic lateral sclerosis, ALS).

7 Mar 2013

CALHM1 protein plays critical role in sweet, bitter and umami taste perception

Working with a multidisciplinary consortium of 19 researchers from nine institutions, Monell scientists have provided critical information to identify CALHM1, a channel in the walls of taste receptor cells, as a necessary component in the process of sweet, bitter, and umami (savory) taste perception.

7 Mar 2013

MicroRNA expression signatures may help define progression of Barrett's esophagus

A series of microRNA expression signatures that may help to define progression of the precancerous condition Barrett's esophagus into esophageal adenocarcinoma was reported recently in Cancer Prevention Research, a journal of the American Association for Cancer Research.

7 Mar 2013

Research illuminates why stimulating environment may protect against Alzheimer's disease

"Use it or lose it." The saying could apply especially to the brain when it comes to protecting against Alzheimer's disease.

7 Mar 2013

Carbamylation contributes to heart disease risk among patients with CKD undergoing dialysis

Kidney failure affects 25 million individuals in the U.S. and many more throughout the world. Loss of kidney function means the majority of these patients must undergo dialysis treatments to remove excess fluids and waste products. Although dialysis therapy coupled with medication has improved the life expectancy for people with kidney failure, for unknown reasons, patients' risk of sudden heart failure and death remains 10 to 20 times greater than average.

7 Mar 2013

Study investigates how cancer cells 'hijack' platelets

A new research study has investigated how cancer cells 'hijack' blood cells known as platelets, enabling cancer to spread around the body and promoting the growth of new tumours, it was reported today at the annual Royal College of Surgeons in Ireland (RCSI) Research Day.

7 Mar 2013

High HDL levels block development of aneurysms in the aorta

New research provides early evidence that 'good' cholesterol may possess anti-aneurysm forming properties. In laboratory-based investigations, scientists found that increased levels of high-density lipoproteins (HDL), the so-called good cholesterol, blocked the development of aneurysms - dangerous 'ballooning' in the wall of a blood vessel - in the body's largest artery, the aorta.

7 Mar 2013

Researchers discover likely origin of epithelial ovarian cancer

Cornell University researchers have discovered a likely origin of epithelial ovarian cancer (ovarian carcinoma), the fifth leading cause of cancer death among women in the United States.

7 Mar 2013

CALHM1 protein controls sense of taste, finds study

In collaboration with other research institutions, a Feinstein Institute for Medical Research investigator discovered a new protein that controls the sense of taste. The findings are published in the March issue of Nature.

7 Mar 2013

Study combines induced pluripotent stem cell technology and genetic correction to treat DMD

Researchers at the University of Minnesota's Lillehei Heart Institute have combined genetic repair with cellular reprogramming to generate stem cells capable of muscle regeneration in a mouse model for Duchenne Muscular Dystrophy (DMD).

7 Mar 2013

Researchers discover how LRRK2 mutations in familial Parkinson's damage brain cells

Researchers at Columbia University Medical Center (CUMC), with collaborators at the Albert Einstein College of Medicine of Yeshiva University, have discovered how the most common genetic mutations in familial Parkinson's disease damage brain cells.

6 Mar 2013

Scientists report successful blocking of tumor development in genetic mouse model of human cancer

UT Southwestern Medical Center scientists report the first successful blocking of tumor development in a genetic mouse model of an incurable human cancer.

6 Mar 2013

Targeting ARF6 may be effectively prevent melanoma metastasis to lungs

Researchers have identified a critical protein role in the metastasis of melanoma, the most serious form of skin cancer.

6 Mar 2013

Scientists discover key biochemical step underlying heart failure

Some 5.8 million Americans suffer from heart failure, a currently incurable disease. But scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine have discovered a key biochemical step underlying the condition that could aid the development of new drugs to treat and possibly prevent it.

6 Mar 2013

European scientists find root cause of age-related dementia

A team of European scientists from the University Medical Center Hamburg-Eppendorf and the Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases at the University of Cologne in Germany has taken an important step closer to understanding the root cause of age-related dementia.

6 Mar 2013

Nordic EMBL Partnership for Molecular Medicine celebrates two important milestones

Today, the Nordic EMBL Partnership for Molecular Medicine celebrates two important milestones: the renewal of the partnership agreement for an extended period of 10 years, and the expansion of the Nordic EMBL network with the official opening of the Danish Research Institute of Translational Neuroscience (DANDRITE) at Aarhus University, which will become its Danish node.

6 Mar 2013

Protein C News and Research

Salty diet may trigger autoimmune disease

CALHM1 channel protein releases ATP to make neural taste connections

Researchers identify role of Merlin in regulating integrity of axons

Study now tells physicians that dystonia can occur in African-American patients

‘New Frontiers in Neurodegenerative Disease Research’ symposium to be held from Feb. 4-7

CALHM1 protein plays critical role in sweet, bitter and umami taste perception

MicroRNA expression signatures may help define progression of Barrett's esophagus

Research illuminates why stimulating environment may protect against Alzheimer's disease

Carbamylation contributes to heart disease risk among patients with CKD undergoing dialysis

Study investigates how cancer cells 'hijack' platelets

High HDL levels block development of aneurysms in the aorta

Researchers discover likely origin of epithelial ovarian cancer

CALHM1 protein controls sense of taste, finds study

Study combines induced pluripotent stem cell technology and genetic correction to treat DMD

Researchers discover how LRRK2 mutations in familial Parkinson's damage brain cells

Scientists report successful blocking of tumor development in genetic mouse model of human cancer

Targeting ARF6 may be effectively prevent melanoma metastasis to lungs

Scientists discover key biochemical step underlying heart failure

European scientists find root cause of age-related dementia

Nordic EMBL Partnership for Molecular Medicine celebrates two important milestones

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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