Mouse Model News and Research

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Old tuberculosis drug improves impaired social behavior in autism mouse model

Reducing the function of the autism-associated gene Pcdh10 leads to impairments in social behavior, according to a study published in Biological Psychiatry.

26 Jan 2017

Prenatal infection-induced epigenetic modifications may alter brain development in offspring

Maternal infection during pregnancy increases the risk for psychiatric disorders in the child, but the path between the two is something of a mystery.

25 Jan 2017

Scientists discover cause of tumour resistance to angiogenesis inhibitors

A new study conducted by MedUni Vienna in collaboration with scientists from Hungary and Sweden has now shown for the first time that the success of specialised drugs to inhibit blood supply to tumours - so-called angiogenesis inhibitors - is compromised by the fact that these drugs do not effectively penetrate the tumour tissue and so do not reach the smallest blood vessels in the tumour.

25 Jan 2017

UAB researchers discover novel underlying mechanism involved in anxiety disorders, PTSD

University of Alabama at Birmingham neurobiologist Lynn Dobrunz, Ph.D., has discovered a novel mechanism for how stress-induced anxiety — the type of experience that can produce post-traumatic stress disorder, or PTSD — affects circuit function in the hippocampus, the area of the brain where aversive memories are formed.

24 Jan 2017

Tulane researchers discover cancer-causing role of protein thought to be tumor suppressor

Tulane University researchers have discovered that the protein PHLDB3, thought to be a potential tumor suppressor, actually allows cancer cells to thrive in pancreatic, prostate, colon, breast, lung, and other common cancers.

24 Jan 2017

Researchers investigate influence of surrounding tissue on formation and growth of tumor cells

Malignant melanoma is the fastest-growing type of cancer and the most fatal skin disease.

23 Jan 2017

Novel approach for imaging immune cell movements identifies initial steps in inflammatory arthritis

Using a novel approach for imaging the movement of immune cells in living animals, researchers from the Massachusetts General Hospital Center for Immunology and Inflammatory Diseases have identified what appear to be the initial steps leading to joint inflammation in a model of inflammatory arthritis.

20 Jan 2017

Scientists identify how early responses of immune system can affect development of EBOV disease

A new mouse model of early Ebola virus infection has shown National Institutes of Health (NIH) scientists and colleagues how early responses of the immune system can affect development of EBOV disease.

18 Jan 2017

Analgesic effects of opioids can be mediated via immune cells

Opioids are the most powerful painkillers. Researchers at the Charité - Universitätsmedizin Berlin have now found that the analgesic effects of opioids are not exclusively mediated by opioid receptors in the brain, but can also be mediated via the activation of receptors in immune cells.

17 Jan 2017

Functional deficits caused by mini-strokes can last longer than previously thought

Evidence overwhelmingly supports a link between cognitive decline and cerebrovascular diseases such as atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy. Not only do individuals with cerebrovascular diseases have a much higher incidence of cortical microinfarcts (mini-strokes), but post-mortem histological and in vivo radiological studies also find that the burden of microinfarcts is significantly greater among people with vascular cognitive impairment and dementia (VCID) than in age-matched, non-demented individuals.

16 Jan 2017

New antibody design may pave way for treating diseases affecting the brain

Immunotherapy has proven to be effective against many serious diseases. But to treat diseases in the brain, the antibodies must first get past the obstacle of the blood-brain barrier.

16 Jan 2017

Study finds that T cells play important role in control of Zika infections

The worst of the global Zika virus outbreak may be over but many key questions remain, such as why the virus persists in certain tissues after the systemic infection has cleared; how does the immune system counteract the virus and protect against reinfection; what determines the likelihood of long-term complications?

12 Jan 2017

S. pneumoniae uses hosts' immune defenses to spread infection, study reveals

The bacteria that cause most cases of pneumonia worldwide secrete a toxin that helps them jump from one body to the next - with help from the hosts' immune defenses. This is the finding of a study led by researchers from NYU Langone Medical Center and published online January 11 in Cell Host & Microbe.

12 Jan 2017

Chronic consumption of western diet leads to overeating and obesity, new research shows

More than two in three adults in the United States are considered overweight or obese, with substantial biomedical and clinical evidence suggesting that chronic overconsumption of a "western diet" - foods consisting high levels of sugars and fats - is a major cause of this epidemic.

12 Jan 2017

New research paves way for better strategies to diagnose and manage vascular graft infections

A rising prevalence of cardiovascular disease has generated substantial growth in the use of medical implants, such as vascular grafts.

11 Jan 2017

Mayo Clinic scientists identify key molecule that helps protect the central nervous system against sepsis

No effective therapy exists today for sepsis, an inflammatory storm that afflicts about 3 million Americans a year - killing up to half.

10 Jan 2017

Researchers create bone-implant interaction mouse model to assess tissue response to biomaterials

To understand the molecular mechanisms involved in the interaction of bone with orthopedic implants comprised of novel biomaterials, researchers have made a mouse model in which they can assess early tissue responses to surfaces such as bioactive glass.

6 Jan 2017

Mouse Model News and Research

Old tuberculosis drug improves impaired social behavior in autism mouse model

Prenatal infection-induced epigenetic modifications may alter brain development in offspring

Scientists discover cause of tumour resistance to angiogenesis inhibitors

UAB researchers discover novel underlying mechanism involved in anxiety disorders, PTSD

Tulane researchers discover cancer-causing role of protein thought to be tumor suppressor

Researchers investigate influence of surrounding tissue on formation and growth of tumor cells

Novel approach for imaging immune cell movements identifies initial steps in inflammatory arthritis

Scientists identify how early responses of immune system can affect development of EBOV disease

Analgesic effects of opioids can be mediated via immune cells

Functional deficits caused by mini-strokes can last longer than previously thought

New antibody design may pave way for treating diseases affecting the brain

Study finds that T cells play important role in control of Zika infections

S. pneumoniae uses hosts' immune defenses to spread infection, study reveals

Chronic consumption of western diet leads to overeating and obesity, new research shows

New research paves way for better strategies to diagnose and manage vascular graft infections

Mayo Clinic scientists identify key molecule that helps protect the central nervous system against sepsis

Researchers create bone-implant interaction mouse model to assess tissue response to biomaterials

Experimental treatment approach reverses cognitive decline and neuropathology in AD mouse model

Researchers uncover two factors that play crucial role in chronic autoimmune disorders

Natural antioxidant can protect offspring of obese mice from NAFLD, study shows

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