Mouse Model News and Research

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New cell reprogramming mechanism could pave way for potential therapies to boost tissue repair

Researchers have identified a mechanism by which cells undergo reprogramming in live mice, a phenomenon that had previously been poorly understood.

24 Nov 2016

New postnatal mouse model closely mimics fetal brain abnormalities caused by Zika infection

A team of scientists led by researchers at the University of Georgia has developed a new mouse model that closely mimics fetal brain abnormalities caused by the Zika virus in humans.

22 Nov 2016

TMDU researchers identify novel type of cell death in Huntington's disease

In Huntington's disease (HD), the huntingtin gene is mutated, causing progressive neuronal death.

22 Nov 2016

Messenger substance may help in future treatment of anxiety disorders

The targeted control of biochemical processes and neuronal signalling pathways using the messenger substance neuropeptide Y could help in the future treatment of anxiety disorders.

22 Nov 2016

Researchers develop new mouse model to study Zika virus and find potential treatments

Researchers have developed a new mouse model that could be used in Zika research to better understand the virus and find new treatments, according to a study published in PLOS Pathogens.

18 Nov 2016

Study finds way to detect early signs of AD by looking at retina of patients' eyes

A new study from The University of Texas Medical Branch at Galveston offers important insight into how Alzheimer's disease begins within the brain.

18 Nov 2016

Scientists develop genetically engineered T cells with fusion inhibitor to disrupt HIV's harpoon

When HIV attacks a T cell, it attaches itself to the cell's surface and launches a "harpoon" to create an opening to enter and infect the cells.

18 Nov 2016

New mouse model by FDA's scientists provides platform for improving understanding of Zika virus pathology

A new mouse model developed by scientists at the U.S. Food and Drug Administration may help in exploring the potential activity of Zika virus vaccines and therapeutics.

17 Nov 2016

Promethera presents new preclinical NASH-Fibrosis data from HepaStem program at AASLD meeting

Promethera Biosciences SA, a world-leading cell therapy and regenerative medicine company targeting liver diseases, today announced the presentation of new preclinical NASH-Fibrosis data from its proprietary HepaStem program, demonstrating a beneficial effect of HepaStem in a nonalcoholic steatohepatitis (NASH) mouse model and confirming Hepastem’s unique and multifaceted mode of action.

15 Nov 2016

Researchers create first mouse model for common form of infant leukemia

After nearly two decades of unsuccessful attempts, researchers from the University of Chicago Medicine and the Cincinnati Children's Hospital Medical Center have created the first mouse model for the most common form of infant leukemia.

15 Nov 2016

Deficiency of tumor suppressor gene may allow brain cancer cells to survive outside niches

Astronauts survive in space by wearing high-tech space suits. But how do brain cancer cells thrive when they migrate to inhospitable sites within the brain?

14 Nov 2016

New research explains how tumors may impair ability of the liver to respond to caloric deprivation

One of the worst cruelties of lethal cancer is the phenomenon called wasting, or in medical terms, cachexia (pronounced ka-CHEX-ia), in which a patient seems literally to diminish in bodily terms as the cancer ravages one or more internal organs.

8 Nov 2016

New mouse models may open ways to develop therapies for ALS patients

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive, fatal neurological disease that attacks the nerve cells controlling voluntary muscles. No effective treatments have been found.

7 Nov 2016

Researchers describe new method that can reveal distinct invasive properties of cancer cells

A research team at Georgetown Lombardi Comprehensive Cancer Center has described the steps, in both written and video format, that allow cancer investigators to track, in real time, cancer cell invasion and metastasis in transparent zebrafish embryos.

4 Nov 2016

Llama antibodies can detect cerebral lesions that characterize Alzheimer's disease

The major challenge facing physicians treating Alzheimer's is the ability to detect markers of the disease as early as possible. These markers, located in the brain, are difficult to access, hampering diagnosis.

4 Nov 2016

Researchers identify heart defects in progeria patients that may raise risk of arrhythmias, premature death

Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III, working in collaboration with colleagues at other centers in Spain and abroad, have identified defects in the hearts of progeria patients that appear to be related to an elevated risk of arrhythmias and premature death.

2 Nov 2016

Disrupted circadian rhythm may not help achieve maximum weight loss after bariatric surgery

A newly released basic science study of Roux-en-Y gastric bypass (RYGB) suggests that a functioning circadian clock, or sleeping at night and being awake during the day, can help patients achieve a higher amount of weight loss following the surgery.

2 Nov 2016

Turning off TAZ protein in liver cells reverses fibrosis in mice

Scientists at Columbia University Medical Center have identified a factor in liver cells that is responsible for turning a relatively benign liver condition, present in 30 percent of U.S. adults, into a serious disease that can lead to liver failure.

27 Oct 2016

NIH researchers identify novel role for Hsp60 protein in tissue regeneration and wound healing

National Institutes of Health researchers have identified a novel role for a gene known as heat shock protein 60 (Hsp60), finding that it is critical in tissue regeneration and wound healing.

27 Oct 2016

Breakthrough Award supports research on role of chronic stress in breast cancer development

Rutgers Cancer Institute of New Jersey resident research member Wenwei Hu, PhD, has received a $596,250 Breakthrough Award from the U.S. Department of Defense through its Breast Cancer Research Program to study the role of chronic stress in breast cancer development.

25 Oct 2016

Mouse Model News and Research

New cell reprogramming mechanism could pave way for potential therapies to boost tissue repair

New postnatal mouse model closely mimics fetal brain abnormalities caused by Zika infection

TMDU researchers identify novel type of cell death in Huntington's disease

Messenger substance may help in future treatment of anxiety disorders

Researchers develop new mouse model to study Zika virus and find potential treatments

Study finds way to detect early signs of AD by looking at retina of patients' eyes

Scientists develop genetically engineered T cells with fusion inhibitor to disrupt HIV's harpoon

New mouse model by FDA's scientists provides platform for improving understanding of Zika virus pathology

Promethera presents new preclinical NASH-Fibrosis data from HepaStem program at AASLD meeting

Researchers create first mouse model for common form of infant leukemia

Deficiency of tumor suppressor gene may allow brain cancer cells to survive outside niches

New research explains how tumors may impair ability of the liver to respond to caloric deprivation

New mouse models may open ways to develop therapies for ALS patients

Researchers describe new method that can reveal distinct invasive properties of cancer cells

Llama antibodies can detect cerebral lesions that characterize Alzheimer's disease

Researchers identify heart defects in progeria patients that may raise risk of arrhythmias, premature death

Disrupted circadian rhythm may not help achieve maximum weight loss after bariatric surgery

Turning off TAZ protein in liver cells reverses fibrosis in mice

NIH researchers identify novel role for Hsp60 protein in tissue regeneration and wound healing

Breakthrough Award supports research on role of chronic stress in breast cancer development

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