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Modified version of anti-nausea drug can enter into cells and provide long-lasting pain relief

Altering the chemical properties of an anti-nausea drug enables it to enter an interior compartment of the cell and provide long-lasting pain relief, according to a new study led by researchers at NYU College of Dentistry's Pain Research Center.

22 May 2023

Identifying risk biomarkers for a serious side effect of stem cell transplants

Doctors are one step closer to having a risk biomarker to alert them to which of their pediatric stem cell transplant patients are likely to experience a potentially deadly side effect called sinusoidal obstruction syndrome (SOS).

22 May 2023

The role of RNA splicing in one of the deadliest forms of pancreatic cancer

In this interview, we spoke to Adrian Krainer, a Professor at Cold Spring Harbor Laboratory, about his latest research into the role of RNA splicing in one of the deadliest forms of pancreatic cancer.

22 May 2023

Remote pulmonary artery pressure monitoring improves quality of life, reduces heart failure hospitalizations

The first investigator-initiated study of remote pulmonary artery pressure monitoring has found that it improves quality of life and reduces heart failure hospitalizations in patients with chronic heart failure.

22 May 2023

Multicenter, 1-year-long real-world study shows effectiveness of semaglutide for weight loss

New research presented at this year's European Congress on Obesity (ECO2023, Dublin, 17-20 May) shows that the obesity drug semaglutide is effective for weight loss in a multicentre, 1-year-long real-world study.

22 May 2023

Genetic insights unveil promising therapeutic targets for critical COVID-19

Critical COVID-19 illness reveals genetic associations with immunomodulatory therapies, as identified in a comprehensive analysis of 24,202 cases. This study uncovers novel genome-wide significant associations, highlighting potential druggable targets for inflammatory signaling, immunometabolism, and viral replication, offering insights into therapeutic implications.

21 May 2023

Breast milk shields newborns: COVID-19 antibodies and microbiota from vaccinated mothers provide dual defense

Research paper discusses the differences in microbiota between high and low IgA subjects after the second dose of the COVID-19 vaccine. The study found that certain microbial features in breast milk can predict levels of anti-SARS-CoV-2 antibodies in breast milk one week post-second dose.

21 May 2023

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Research describes the development of a synthetic delivery vector called STxB for mucosal vaccination. It induces mucosal immunity, including resident memory CD8+ T cells and IgA antibodies, against antigens derived from mucosal viruses when administered intranasally in mice.

21 May 2023

Tirzepatide improves body composition across a range of adult age groups, study shows

A new analysis of SURMOUNT-1, the first Phase 3 study of tirzepatide in adults for chronic weight management shows that tirzepatide improves body composition across a range of adult age groups.

19 May 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.

19 May 2023

COVID's latest twist: New XBB variant gains strength through recombination, outsmarting immunity and amplifying fusogenicity

Research discusses the emergence of a highly diversified SARS-CoV-2 Omicron subvariant called XBB, which is spreading rapidly around the world. XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1, during the summer of 2022.

18 May 2023

Researchers discover how corticosteroids influence inflammatory response during COVID-19 infection

Since the start of the COVID-19 pandemic, a class of corticosteroids called glucocorticoids (GCs) have become established as one of the main treatment options, especially for severe cases, thanks to their anti-inflammatory and immunosuppressant action.

18 May 2023

Biosensor Versatility; From Analytical Chemistry to Diagnostics

At Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to this year's recipient of the Ralph N. Adams Award in Analytical Chemistry, Professor Joseph Wang to discuss the versatility of biosensor technologies.

From Pittcon 18 May 2023

How the gut microbiome supports iron uptake by intestinal regulatory T-cells

Research paper discusses the relationship between iron deficiencies and immune tolerance in patients with inflammatory bowel disease. The study shows that high cellular iron levels fostered by pentanoate, a short-chain fatty acid produced by intestinal microbiota, are necessary for the homeostasis of regulatory T cells in the intestine, and iron deficiencies in Treg can result in lethal autoimmune disease.

17 May 2023

Novel computational platform can expand the pool of cancer immunotherapy targets

Researchers at Children's Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets.

17 May 2023

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Researchers generated six human monoclonal antibodies that prevented infection.

17 May 2023

Study unveils ATP as a key player in ovulation, paves the way for novel infertility treatments

Research explores the role of ATP as a potential neurotransmitter in stimulating kisspeptin neurons to induce ovulation in rodents. The findings shed light on the neurobiological mechanisms involved in ovulation and may have implications for understanding and treating ovulation disorders.

16 May 2023

Obesity undermines COVID-19 vaccines

Researchers examine the impact of obesity on COVID-19 outcomes and the effectiveness of vaccines in individuals with obesity. Using data from Scotland, the study explores the relationship between body mass index (BMI) and hospitalization/mortality due to COVID-19.

15 May 2023

UArizona Health Sciences researchers seek to improve opioid therapy while decreasing its side effects

University of Arizona Health Sciences researchers are taking the foot off the brake in their quest to improve opioid therapy while decreasing its side effects.

15 May 2023

Cyclical estrogen/anti-estrogen therapy could be a promising strategy to treat metastatic ER+ breast cancer

Advanced or metastatic estrogen receptor-positive (ER+) breast cancer is commonly treated with drugs that block the estrogen receptor.

15 May 2023

Receptor News and Research

Modified version of anti-nausea drug can enter into cells and provide long-lasting pain relief

Identifying risk biomarkers for a serious side effect of stem cell transplants

The role of RNA splicing in one of the deadliest forms of pancreatic cancer

Remote pulmonary artery pressure monitoring improves quality of life, reduces heart failure hospitalizations

Multicenter, 1-year-long real-world study shows effectiveness of semaglutide for weight loss

Genetic insights unveil promising therapeutic targets for critical COVID-19

Breast milk shields newborns: COVID-19 antibodies and microbiota from vaccinated mothers provide dual defense

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Tirzepatide improves body composition across a range of adult age groups, study shows

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

COVID's latest twist: New XBB variant gains strength through recombination, outsmarting immunity and amplifying fusogenicity

Researchers discover how corticosteroids influence inflammatory response during COVID-19 infection

Biosensor Versatility; From Analytical Chemistry to Diagnostics

How the gut microbiome supports iron uptake by intestinal regulatory T-cells

Novel computational platform can expand the pool of cancer immunotherapy targets

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Study unveils ATP as a key player in ovulation, paves the way for novel infertility treatments

Obesity undermines COVID-19 vaccines

UArizona Health Sciences researchers seek to improve opioid therapy while decreasing its side effects

Cyclical estrogen/anti-estrogen therapy could be a promising strategy to treat metastatic ER+ breast cancer

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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