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Texas A&M team continues research on the potential cure for Menkes disease

A life-saving cure solution for Menkes Disease, a copper deficiency in young children, is at the center of a licensing agreement by the The Texas A&M University System, through the Intellectual Property and Commercialization office of Texas A&M AgriLife Research, and a California-based biopharmaceutical company, Engrail Therapeutics.

3 Mar 2022

Blood groups play a key role in whether people develop severe COVID-19, study suggests

A new study has analyzed over 3000 proteins to identify which are causally linked to the development of severe COVID-19.

3 Mar 2022

Angiotensin-converting enzyme 2-based mutant decoy effectively reduces COVID-19 in mice

Researchers engineered a mutant ACE2 decoy that effectively protected human lung epithelia from SARS-CoV-2 infection by competitively binding to its spike protein.

3 Mar 2022

Theoretical biologists capture the mechanisms underlying evolvability

All life evolves: microorganisms can become resistant to drugs, viruses evade our vaccines, and species may adapt to climate change.

3 Mar 2022

8G3 broad-spectrum antibody effective against all SARS-CoV-2 variants, including Omicron

Researchers assess the efficacy of 8G3, a B-cell neutralizing antibody against SARS-CoV-2 variants, including the most recent Omicron variant.

3 Mar 2022

Identifying and managing drug-drug interactions key to the safe use of nirmatrelvir–ritonavir in COVID-19 treatment

Researchers compiled evidence-based recommendations in consultation with European and North American clinicians and pharmacologists for recognizing and managing drug-drug interactions with nirmatrelvir–ritonavir.

3 Mar 2022

Scientists find no connection between pandemic chilblains and SARS-CoV-2 infection

A recent study provides a better understanding of whether SARS-CoV-2 infection is linked with the occurrence of chilblains.

3 Mar 2022

Sugar-decorated proteins in mucus could prevent SARS-CoV-2 viruses from spreading from surfaces

Early in the pandemic, many people fastidiously disinfected surfaces because laboratory studies predicted that SARS-CoV-2 could be easily transmitted in this way.

2 Mar 2022

Peripubertal stress leads to increase in adipose tissue and reduces sociability

Between the end of childhood and the beginning of adolescence, there is a critical window of time referred to as "peripuberty".

2 Mar 2022

Serological test to assess presence of immunoglobulin isotypes targeted against antigens routinely used in COVID-19 diagnosis

The current study discusses a reliable ELISA that can detect three isotypes of antibody against three SARS-CoV-2 antigens.

2 Mar 2022

Scientists reveal molecular mechanisms behind bone loss caused by chronic liver injury

A research team led by Prof. Chen Di from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences along with other collaborators have revealed the molecular mechanisms behind bone loss caused by chronic liver injury.

1 Mar 2022

Exploring Oxford nanopore technology-based on-site SARS-CoV-2 genome sequencing

In a new study, researchers performed genomic sequencing of SARS-CoV-2-infected samples and aimed to identify the dominant variant, assess the mutation profile, and determine the sample-to-sequence turnover time.

1 Mar 2022

Analyzing transcriptomic landscape of SARS-CoV-2-infected lung cells

In a new study, researchers used deep transcriptome analysis to examine the coding and non-coding transcriptional landscape of lung cells infected with SARS-CoV-2.

1 Mar 2022

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Researchers used deep mutational scans to measure the effect of each amino-acid mutation in the receptor-binding domain of SARS-CoV-2 Wuhan-Hu-1, Alpha, Beta, Delta, and Eta variants.

1 Mar 2022

SARS-CoV-2 protein interactions with viral and host RNAs in authentic virus-infected cells

Researchers investigated protein interactions of SARS-CoV-2 with host and viral RNAs in infected cells.

1 Mar 2022

Recombinant adenovirus vector vaccine generates mucosal antibodies against SARS-CoV-2

In a recent study posted to the bioRxiv* server, researchers assessed the immunogenicity of the self-developed recombinant adenovirus vector (rAd5) vaccine on macaques. They evaluated the efficacy of three candidate vaccines, ED88, ED90, and ED94, to select the most appropriate one for future development.

1 Mar 2022

Enzyme News and Research

Texas A&M team continues research on the potential cure for Menkes disease

Blood groups play a key role in whether people develop severe COVID-19, study suggests

Angiotensin-converting enzyme 2-based mutant decoy effectively reduces COVID-19 in mice

Theoretical biologists capture the mechanisms underlying evolvability

8G3 broad-spectrum antibody effective against all SARS-CoV-2 variants, including Omicron

Identifying and managing drug-drug interactions key to the safe use of nirmatrelvir–ritonavir in COVID-19 treatment

Scientists find no connection between pandemic chilblains and SARS-CoV-2 infection

Sugar-decorated proteins in mucus could prevent SARS-CoV-2 viruses from spreading from surfaces

Peripubertal stress leads to increase in adipose tissue and reduces sociability

Serological test to assess presence of immunoglobulin isotypes targeted against antigens routinely used in COVID-19 diagnosis

Scientists reveal molecular mechanisms behind bone loss caused by chronic liver injury

Exploring Oxford nanopore technology-based on-site SARS-CoV-2 genome sequencing

Analyzing transcriptomic landscape of SARS-CoV-2-infected lung cells

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

SARS-CoV-2 protein interactions with viral and host RNAs in authentic virus-infected cells

Recombinant adenovirus vector vaccine generates mucosal antibodies against SARS-CoV-2

Biophysical fitness profile of SARS-CoV-2 Delta variant

COVID-19 severity is correlated with body composition

Histopathologic and molecular effects in the placenta after SARS-CoV-2 infection during pregnancy

Peptide-based vaccine fails to protect mice against SARS-CoV-2 despite T cell response

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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