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Study reveals how serotonin affects animal behavior at the whole-brain scale

Because serotonin is one of the primary chemicals the brain uses to influence mood and behavior, it is also the most common target of psychiatric drugs.

15 May 2023

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Researchers at Baylor College of Medicine/Texas Children's Cancer Center and collaborating institutions report interim results from a first-in-human phase 1 clinical trial evaluating the safety, antitumor activity and immunological characteristics of a genetically engineered natural killer T (NKT) cell immunotherapy for neuroblastoma, a childhood tumor that most commonly arises in the adrenal gland.

15 May 2023

Newly identified genetic variant provides protection from Alzheimer's disease

A single patient can spark new research questions and provide answers about a disease. And when a new case is identified, investigators can make connections between them that can lead to even more powerful and persuasive ideas about cause and treatment.

15 May 2023

Supercharge your health with carotenoids

This review highlights carotenoids' various biological activities, including antioxidant, anti-tumor, anti-diabetic, anti-aging, and anti-inflammatory effects, with a specific focus on lycopene.

15 May 2023

SARS-CoV-2 variants show altered glycan processing

Researchers examine spike-protein trimers from SARS-CoV-2 variants to compare the N (asparagine)-glycan landscape.

15 May 2023

Deep generative models to generate hypothetical SARS-CoV-2 spike sequences

Scientists explore the use of deep generative models in producing complete instances of as-yet undiscovered SARS-CoV2 Spike protein sequences. The resulting models substantially outperform a state-of-the-art generative model for protein sequences finetuned on SARS-CoV2 data.

14 May 2023

Newly identified biomarker may predict NSCLC patients' treatment response to chemoimmunotherapy

Cutting-edge cancer treatments like immunotherapy are offering new hope for patients, often in combination with more common approaches such as chemotherapy. But determining the best treatment combination isn't always straightforward.

12 May 2023

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Researchers conducted a phase I clinical trial of a personalized mRNA neoantigen vaccine.

12 May 2023

Study identifies extremely potent monoclonal antibodies that neutralized multiple sarbecoviruses

Researchers longitudinally isolated immensely potent monoclonal antibodies from macaques vaccinated with COVID-19.

12 May 2023

Extracellular chaperones mediate the lysosomal degradation of misfolded proteins

When exposed to stressful conditions, several proteins tend to misfold and form aggregates inside or outside cells.

11 May 2023

Unlocking the secrets of Omicron: study reveals how unique spike mutations enable enhanced infectivity and resistance to immune barrier

Researchers reported the increased transmissibility of the severe acute respiratory syndrome coronavirus 2.

11 May 2023

Researchers advance the understanding of sperm maturation

Fertility has long been cherished across humankind. Now, in a study published in Nature Communications, researchers from Osaka University have furthered our understanding of sperm maturation.

10 May 2023

Cardiovascular risk reduction in type 2 diabetes: Study urges better use of life-saving therapies

Researchers explore the efficacy of current approaches to reduce the risk of cardiovascular events in patients with type 2 diabetes.

10 May 2023

Air pollution exacerbates movement disorder after ischemic stroke

Air pollution has been shown to have a negative effect on the prognosis of ischemic stroke, or stroke caused by reduced blood flow to the brain, but the exact mechanism is unknown.

10 May 2023

The potential variations in sperm quality of infertile patients during the COVID-19 pandemic

A recent study investigated how SARS-CoV-2 infection affected the semen quality of infertile men in Tunisia.

10 May 2023

Environmental PAH exposure associated with increased rheumatoid arthritis risk

The amount of environmental exposure to polycyclic aromatic hydrocarbons, or PAH for short, is strongly linked to a person's risk of developing rheumatoid arthritis, suggests research published in the open access journal BMJ Open.

10 May 2023

New study finds elevated inflammatory cytokines and lymphocytes linked to rare cases of myocarditis after COVID-19 vaccination

Researchers investigated a cohort of patients who developed myocarditis after SARS-CoV-2 mRNA vaccination.

10 May 2023

New SNAP approach to customizing T cell-based immunotherapies

University of Pittsburgh researchers have developed a universal receptor system that allows T cells to recognize any cell surface target, enabling highly customizable CAR T cell and other immunotherapies for treating cancer and other diseases.

9 May 2023

Boosting gut health with short-chain fatty acids

Research paper provides an overview of short-chain fatty acids (SCFAs) and their role in regulating gut homeostasis. It also discusses SCFA-producing bacteria and potential therapeutic approaches to boost SCFA levels in the gut to treat related diseases.

9 May 2023

Experts urge increased attention to the threat of climate change and pollution on children's health

Study explores the impact of climate change and environmental chemicals on children's health.

9 May 2023

Receptor News and Research

Study reveals how serotonin affects animal behavior at the whole-brain scale

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Newly identified genetic variant provides protection from Alzheimer's disease

Supercharge your health with carotenoids

SARS-CoV-2 variants show altered glycan processing

Deep generative models to generate hypothetical SARS-CoV-2 spike sequences

Newly identified biomarker may predict NSCLC patients' treatment response to chemoimmunotherapy

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Study identifies extremely potent monoclonal antibodies that neutralized multiple sarbecoviruses

Extracellular chaperones mediate the lysosomal degradation of misfolded proteins

Unlocking the secrets of Omicron: study reveals how unique spike mutations enable enhanced infectivity and resistance to immune barrier

Researchers advance the understanding of sperm maturation

Cardiovascular risk reduction in type 2 diabetes: Study urges better use of life-saving therapies

Air pollution exacerbates movement disorder after ischemic stroke

The potential variations in sperm quality of infertile patients during the COVID-19 pandemic

Environmental PAH exposure associated with increased rheumatoid arthritis risk

New study finds elevated inflammatory cytokines and lymphocytes linked to rare cases of myocarditis after COVID-19 vaccination

New SNAP approach to customizing T cell-based immunotherapies

Boosting gut health with short-chain fatty acids

Experts urge increased attention to the threat of climate change and pollution on children's health

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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