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Study reveals how FOXA1 mutations drive prostate cancer and therapy resistance

A new study from the University of Michigan Rogel Health Cancer Center, published in Science, sheds light on how two distinct classes of mutations in the FOXA1 gene-commonly altered in prostate cancer-drive tumor initiation formation and therapeutic resistance.

26 Jun 2025

Inflammatory cells may persist despite biologic therapy in severe asthma

Biological drugs have improved the lives of many people with severe asthma. However, a new study from Karolinska Institutet in Sweden shows that some immune cells with high inflammatory potential are not completely eradicated after treatment.

26 Jun 2025

Earlier anticoagulant use could prevent repeat strokes in atrial fibrillation patients

Patients with atrial fibrillation who have experienced a stroke would benefit greatly from earlier treatment than is currently recommended in current UK guidelines, finds a new study led by UCL (University College London) researchers.

26 Jun 2025

NANOSPRESSO device brings precision medicine to hospital pharmacies

A new gene therapy delivery device could let hospital pharmacies make personalized nanomedicines to order.

26 Jun 2025

Surgery and speech therapy improve chronic post-stroke aphasia

Combining neck surgery with intensive speech therapy is associated with greater improvements in a person's ability to communicate after a stroke than intensive speech therapy alone, finds a clinical trial published by The BMJ today.

26 Jun 2025

More people survive heart attacks but face ongoing cardiac risks

In 1970, someone over the age of 65 hospitalized for a heart attack in the United States had about a 60% chance of leaving the hospital alive. Today, the survival rate is over 90%, with even better outcomes for younger patients.

26 Jun 2025

Targeting the tumor microenvironment to improve osteosarcoma outcomes

The complex tumor microenvironment (TME) in osteosarcoma is emerging as a critical factor in disease progression and treatment resistance.

26 Jun 2025

Performance pay initially boosted GP care but gains did not last

Introducing performance related pay for UK general practices initially improved quality of care, but did not seem to provide lasting improvements beyond that expected by previous trends, finds a study published by The BMJ today.

26 Jun 2025

Hot tubs may offer greater health benefits than saunas

Hot tubs and saunas can both soothe aching muscles and provide welcome warmth, but hot tubs might offer greater health benefits.

26 Jun 2025

Regular sexual activity can reduce problematic menopause symptoms, study suggests

It's no secret that women often become less interested in sex with age. However, orgasm and satisfaction have been shown to not decline significantly with age.

25 Jun 2025

Virtual canine modules offer mental health support

While it's well known that spending time with dogs can ease stress, new research shows that watching a short video of a dog can have a similar comforting effect.

25 Jun 2025

New pretreatment method boosts islet transplant survival in diabetes

A pretreatment step could help transplanted pancreatic islets survive longer in patients with type 1 diabetes, according to a new preclinical study from Weill Cornell Medicine investigators. One combination of small molecules extended the cells' lives in female mice, and adding two molecules to the mixture boosted cell survival in male mice.

25 Jun 2025

Scientists use base editing to repair mitochondrial DNA mutations

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor.

25 Jun 2025

Flexible wireless implant offers hope for chronic pain sufferers

Chronic pain is a debilitating condition that severely impacts quality of life, often leading to reliance on opioid medications with their severe side effects and addiction risks.

24 Jun 2025

Novel combination therapy targets m6A pathway to combat joint erosion in rheumatoid arthritis

A recent study published in Engineering has shed light on a novel combination therapy for rheumatoid arthritis (RA) that significantly reduces bone destruction by targeting the m6A methylation pathway.

24 Jun 2025

ADC189 shows promise as a single-dose treatment for influenza

Influenza continues to pose a significant global health burden, with seasonal outbreaks causing substantial morbidity and mortality.

24 Jun 2025

New AI tool characterizes the diversity of individual cells within tumors

A multinational team of researchers, co-led by the Garvan Institute of Medical Research, has developed and tested a new AI tool to better characterize the diversity of individual cells within tumors, opening doors for more targeted therapies for patients.

24 Jun 2025